- Research Article
- Open Access
- Open Peer Review
Costs of potentially inappropriate medication use in residential aged care facilities
BMC Geriatrics volume 18, Article number: 9 (2018)
The potential harms of some medications may outweigh their potential benefits (inappropriate medication use). Despite recommendations to avoid the use of potentially inappropriate medications (PIMs) in older adults, the prevalence of PIM use is high in different settings including residential aged care. However, it remains unclear what the costs of these medications are in this setting. The main objective of this study was to determine the costs of PIMs in older adults living in residential care. A secondary objective was to examine if there was a difference in costs of PIMs in a home-like model of residential care compared to an Australian standard model of care.
Participants included 541 participants from the Investigation Services Provided in the Residential Environment for Dementia (INSPIRED) Study. The INSPIRED study is a cross-sectional study of 17 residential aged care facilities in Australia. 12 month medication costs were determined for the participants and PIMs were identified using the 2015 updated Beers Criteria for older adults.
Of all of the medications dispensed in 1 year, 15.9% were PIMs and 81.4% of the participants had been exposed to a PIM. Log-linear models showed exposure to a PIM was associated with higher total medication costs (Adjusted β = 0.307, 95% CI 0.235 to 0.379, p < 0.001). The mean proportion (±SD) of medication costs that were spent on PIMs in 1 year was 17.5% (±17.8) (AUD$410.89 ± 479.45 per participant exposed to a PIM). The largest PIM costs arose from proton-pump inhibitors (34.4%), antipsychotics (21.0%) and benzodiazepines (18.7%). The odds of incurring costs from PIMs were 52% lower for those residing in a home-like model of care compared to a standard model of care.
The use of PIMs for older adults in residential care facilities is high and these medications represent a substantial cost which has the potential to be lowered. Further research should investigate whether medication reviews in this population could lead to potential cost savings and improvement in clinical outcomes. Adopting a home-like model of residential care may be associated with reduced prevalence and costs of PIMs.
Polypharmacy, i.e. the use of five or more medications, is high in residential aged care facilities . Furthermore, the potential harms of some medications may outweigh their potential benefits (inappropriate medication use). Inappropriate polypharmacy is not only associated with an increased risk of adverse drug reactions, but also an increased risk of disability, unplanned hospitalizations and mortality .
In 2015 the Beers Criteria for potentially inappropriate medication (PIM) use in older adults were updated by the American Geriatrics Society . The Beers Criteria provide a comprehensive list of PIMs; the majority of the medications included in the Beers Criteria are strongly recommended to be avoided in older adults, and the evidence to support these recommendations was largely rated as moderate or high quality . PIMs, according to the Beers Criteria, have been associated with increased risks of hospitalization and mortality in older people in residential care . In addition to their potential adverse health effects and negative effect on quality of life, the use of PIMs may also lead to higher health care costs [5, 6].
An additional Beers Criteria list specific for older adults with dementia or cognitive impairment is also included in the 2015 update. The evidence to support the development of this list was rated as moderate quality by the authors of the Beers Criteria. The authors strongly recommend avoiding medications within this list in older adults with dementia or cognitive impairment because these medications may cause adverse central nervous system effects, and because of the association of antipsychotics with a greater risk of stroke and mortality in people with dementia .
Despite recommendations to avoid the use of PIMs in older adults, the prevalence of PIM use has been shown to be high in a number of different settings including residential aged care. Approximately one half of aged care residents have been previously shown to be exposed to PIMs . However, it remains unclear what the costs of these medications are in this setting.
It has not previously been shown if different models of residential care can affect the use of PIMs. Models of residential care for older adults that aim to provide small group home-like environments and encourage independence for the residents have been of increasing interest [8, 9]. The World Health Organization stated that these models ‘hold promise’ for the residents, family members and staff . However, the effectiveness of these home-like residential care models needs to be further examined . Living in home-like residential care models may improve quality of life for residents , whether this is reflected in exposure to PIMs has not previously been investigated.
The objectives of this study were to determine exposure to and cost of PIMs according to the 2015 updated Beers Criteria for all older adults living in residential care and the additional criteria for people living with cognitive impairment and dementia. Further, we examined if there was a difference in the amount spent on these medications in a home-like residential care model compared to a standard model of care.
The Investigating Services Provided in the Residential Environment for Dementia (INSPIRED) study is a cross-sectional observational study of residential aged care facilities in Australia and was designed to include participants with cognitive impairment and dementia. The study received ethics approval from the Flinders Social and Behavioural Research Ethics Committee. The study aimed to include facilities from areas representing different socioeconomic backgrounds, geographic locations (e.g. rural vs metropolitan locations) and different states of Australia. In total, 17 facilities in Australia (including South Australia, New South Wales, Western Australia, and Queensland) participated in the study. Participants self-consented to be involved in the study or, where more severe cognitive impairment was present, informed consent and information was provided by a proxy, usually a close family member (76% of the participants). To be eligible for participation in the study the participants needed to: 1) have been a permanent resident in the facility for 12 months or more, 2) have not been in immediate palliative care, 3) have no complex medical or family issues which would impede their participation and 4) have a family member available and willing to participate on their behalf if a proxy was required.
In total, 1323 potential participants were assessed for eligibility and 901 were eligible to participate; of these 60% (n = 541) consented. Data collection was completed between January 2015 and February 2016.
Medication use was primarily based on dispensing records obtained from the appropriate pharmacy. Data for dispensing of the medication in the 365 days prior to the study start date for the facility was collected (hereafter referred to as 12 month medication records). Of the study participants, 3.5% (n = 19) did not have pharmacy records available, and reviews of their medication charts were undertaken instead. For two of the facilities (both standard model facilities) the pharmacy records only reported a single instance for the initial dispensing date of the medication, rather than all dates of provision of the medication, hence, Pharmaceutical Benefits Scheme (PBS) records were used to determine medication use and costs. In Australia, under the PBS, the government subsidises costs of many prescription medications for Australian residents. Accordingly, the majority of dispensed medications will be found in PBS records.
Potentially inappropriate medications
PIMs were identified using the 2015 updated Beers Criteria . Only the medications which are listed as PIMs for all older adults (i.e. not those which are dependent on diagnosis) were considered for analysis of utilisation in all participants. Participants were deemed to have been exposed to a PIM if they had been prescribed at least one medication included in the Beers Criteria in the previous 12 months. Furthermore, we also completed a subgroup analysis to examine the Beers Criteria specific for people with cognitive impairment and dementia in addition to the Beers Criteria for all older adults. Only participants with a Psychogeriatric Assessment Scale-Cognitive Impairment Scale (PAS-Cog) score of more than 4 and/or a formal diagnosis of dementia were included in this secondary analysis. As the Beers Criteria were developed for the USA, some medications were added to the PIMs lists by research pharmacists to allow for the Australian register of pharmaceutical products; these medications were in the same classes as medications that were included in the Beers Criteria lists (Additional file 1: Table S1).
Costs of the medications
The costs of the medications were based on the Dispensed Price for Maximum Quantity (DPMQ) for the medications extracted from the PBS . The DPMQ incorporates the “price ex-manufacturer, including all fees, mark-ups and patient contributions” . The medication codes were matched to the DPMQ costs as of the 1st March 2016 PBS i.e. costs at the time of completion of the study. Where a DPMQ for a medication was not available in the 1st March 2016 listings the PBS cost for the nearest available month was used.
The 12 month cost of each participant’s PIMs was calculated and estimated as a proportion of their total medication costs for the 12 months. Costs are reported in Australian dollars (AUD). Where US dollars are reported a March 2016 exchange rate of $1.00 AUD to $0.7814 US was used .
Models of residential care
The INSPIRED study includes some facilities which have adopted a home-like model of residential care, in addition to more standard large-scale facilities. These home-like models of residential care are small houses specifically designed and built to provide person-centred care for residents with dementia, in an environment that looks and feels more like a domestic home. These facilities aim to encourage residents to live in a more independent manner and to contribute to the domestic duties of the units. The facilities which had a home-like model were defined by each having at least five of the following six key components: 1) small size (maximum 15 residents), 2) accessible outdoor areas which residents can use independently, 3) continuity of care staff allocated to units to ensure continuity of care, 4) meals cooked within the units, 5) meals put on table for self-service, 6) residents assist with meal preparation . These descriptive criteria were based on similar models of care described elsewhere [8, 14,15,16] and were agreed in consultation with an advisory group including consumer representatives from the Alzheimer’s Australia Consumer Dementia Research Network (who were informal caregivers), clinicians, health services researchers, and representatives of long-term care providers.
Data collected from the participants included PAS-Cog scores which provide an overall measure of cognitive functioning, modified Barthel Index scores which measure activities of daily living, and Neuropsychiatric Inventory (NPI) scores which measure behaviour. Social interaction was defined as visits by family, friends or neighbours at least once a week. Comorbidities were extracted from the medical records of the participants and grouped into one of ten disease categories (excluding dementia) as used by Cohen-Mansfield and colleagues . Data collected regarding the facility included information from a standardised questionnaire based on the work of a previous study  and was completed by a member of staff from each facility.
The costs were positively skewed and were therefore log transformed to correct this to a normal distribution. For the total medication costs there were no zero values and therefore multivariate linear models of the transformed costs were used to assess the ratio of mean total medication costs by exposure to a PIM. As the costs of PIMs included many zero values, two-part models were used to assess the ratio of mean total costs of PIMs [19, 20]. First, a logistic regression model was used to predict the probability of any cost of PIMs more than zero in a home-like model of care compared to a standard model of residential care. Second, a log-normal model weighted by the probability of cost more than zero was used to model nonzero cost of PIMS associated with residing in a home-like model of care compared to a standard model of residential care. Models were adjusted for the following potential confounding factors: age, sex, marital status, activities of daily living as measured by the modified Barthel Index, social interactions, number of comorbidities, NPI scores and PAS-Cog scores. The level of statistical significance was set at p < 0.05. All analyses were completed using Stata v.14.0 (Stata Corp LP, College Station, TX, USA).
Characteristics of the participants
The mean (±SD) age of the participants was 85.5 (±8.5) years old and 74.5% (n = 403) were female. Of the total participants, 82.8% (n = 448) had some level of cognitive impairment based on their PAS-Cog score and 64.3% (n = 348) had a dementia diagnosis.
No medication data were available for eight of the participants; the final sample comprised of 533 participants (98.5%). In this study, 81.4% (n = 434) of the participants had been exposed to a PIM during the 12 month period. Of all of the medications dispensed in this period, 15.9% were PIMs. Those who were not exposed to a PIM were more likely to be older (p = 0.005), have a diagnosis of dementia (p = 0.002) and live in a home-like model of residential care (p = 0.02) (Table 1).
Costs of all medications over 12 months
The mean (±SD) number of different types of medications that participants were exposed to over the 12 month period was 14.5 (±6.5). The mean (±SD) cost for all medications in the 12 month period was AUD$1991.86 (±1538.76) (US$1556.44 (±1202.47)).
Costs of potentially inappropriate medications
Table 2 shows the proportions of each type of PIM using the list of PIMs for all older adults. The most common PIMs included proton-pump inhibitors prescribed for > 8 weeks (42.2% exposed to a proton-pump inhibitor prescribed for > 8 weeks in the previous 12 months), benzodiazepines (37.9%) and antipsychotics (30.6%). The prevalence of other PIMs were all relatively low (< 10%). The prevalence of antidepressants classified as PIMs was 6.4%, however, the prevalence of any antidepressant was high (52.5%) and these should be used with caution in older adults according to the Beers Criteria.
Table 3 shows the costs of the PIMs. The mean (±SD) cost for all PIMs in the 12 month period was AUD$410.89 (±479.45) (US$ 327.07 (±374.64)) per participant. The mean (±SD) proportion of total medication costs that were PIMs was 17.5% (±17.8). When examining the different classes of PIMs the largest mean (±SD) costs in the 12 month period were for proton-pump inhibitors (AUD$139.54 (±163.58) US$109.04 (±127.82)) and antipsychotics (AUD$85.11 (±202.83) US$66.50 (±158.49)). Those who were exposed to a PIM were more likely to have higher total medication costs (β = 0.307, 95% CI 0.235 to 0.379, p < 0.001), after adjusting for potential confounding factors (Table 4).
Potentially inappropriate medications by model of residential care
Four facilities (23.5%) were classified as a home-like model of residential care including 22.2% (n = 120) of the participants. These home-like facilities all provided specialised dementia care and 98.3% of the participants in these facilities had a diagnosis of dementia. The first part of the two-part model (logistic regression model) estimates a significant odds ratio of e(−0.735) = 0.48 (p = 0.008), indicating that the odds of incurring any costs from PIMs was 52% lower for those living in a home-like model of residential care, after adjusting for potential confounding factors. The second part of the model (log-normal model) indicates residing in a home-like model of care was marginally associated (p = 0.064) with lower costs of PIMs over 12 months (mean cost ratio = e-0.277 = 75.8%, therefore 24.2% lower costs) after accounting for those with zero costs (Table 5).
Costs of potentially inappropriate medications for dementia and cognitive impairment: Subgroup analysis
In total, 86.5% (n = 461) of the participants had dementia or cognitive impairment and were included in this analysis. Of these participants, 81.3% (n = 375) had been exposed to a PIM that is not recommended for older adults and/or contraindicated in dementia or cognitive impairment. The mean (±SD) cost for these PIMs in the 12 month period was AUD$416.93 (±499.86). The mean (±SD) proportion of total medication costs that were PIMs for those with cognitive impairment and dementia was 18.3% (±18.3). When examining the different classes of PIMs the largest mean (±SD) costs in the 12 month period were for proton-pump inhibitors prescribed for > 8 weeks (AUD$126.07 ± 156.35) and antipsychotics (AUD$93.76 ± 211.87). The logistic regression model estimates a significant odds ratio of e(−0.724) = 0.48 (p = 0.011), indicating that the odds of incurring any costs from PIMs was 52% lower for those living in a home-like model of residential care, after adjusting for potential confounding factors. The log-normal model indicates residing in a homelike model of care was marginally associated (p = 0.051) with the lower costs of PIMs over 12 months (mean cost ratio = e-0.284 = 75.3%, indicating 24.7% lower costs) after excluding those with zero costs.
This is the first study that has examined the 12 month costs of PIMs in older adults in residential care with a high prevalence of cognitive impairment and dementia using the updated Beers Criteria, to the author’s knowledge. This analysis has demonstrated that over 80% of participants had been exposed to a PIM over a 12 month period and approximately 16% of all medications dispensed in this 12 month period were PIMs. Those exposed to a PIM were more likely to have higher total medication costs. The highest exposures to PIMs were for proton-pump inhibitors prescribed for more than 8 weeks, benzodiazepines and antipsychotics. Furthermore, those who resided in a home-like model of residential care were less likely to incur any costs due to PIMs.
Few previous studies have provided period prevalence estimates for PIMs over 12 months in residential aged care settings. Previous studies have shown the prevalence of PIMs taken at a single time point (point prevalence) by older adults in residential care settings to be approximately 50% [7, 21]. However, this estimate has varied in different populations; in a Brazilian study this was reported to be as high as 82.6%, with 32% of all medications being PIMs . The fact that the period prevalence of PIMs in this study over 12 month period was high is unsurprising. The population examined in this study had a high prevalence of cognitive impairment and dementia; all resided in an aged care facility and the mean age was over 85 years. It is therefore expected that exposure to PIMs would be higher than in studies of community-dwelling older adults or relatively younger age groups. For instance, PIM exposure has been shown to be higher in women aged 85 years and over . The current study adds to the body of evidence by using the 2015 updated Beers Criteria and examining a population of long-term aged care residents with a high prevalence of cognitive impairment and dementia.
In this study the highest exposure to PIMs were due to proton-pump inhibitors, benzodiazepines and antipsychotics. This profile of use is similar to previous studies which have found proton-pump inhibitors to be the largest cause of PIM exposure for older people . Proton-pump inhibitor use in older adults has been associated with an increased risk of bone loss and fractures, Clostridium difficile infection, community-acquired pneumonia, and vitamin and mineral deficiencies . There was also high-exposure to psychotropic PIMs (benzodiazepines and antipsychotics), which are frequently associated with adverse effects in older adults, including falls, hospitalization, cardiovascular complications, adverse mental state changes and mortality in older people in residential care . The use of antipsychotics for some of the participants in the current study may be appropriate, given the high prevalence of dementia in this study. However, guidelines recommend use of antipsychotics only in rare cases for those with extreme behavioural and psychological symptoms of dementia (BPSD) [27, 28], and therefore the use of antipsychotics in 30% of the study population at some stage during the previous 12 months indicates that a significant proportion of use is likely to be inappropriate. Furthermore, although we found the prevalence of antidepressants classified as PIMs to be quite low, we found the prevalence of any antidepressant use was high (over 50%). Some of the use of these additional antidepressants (SSRIs and SNRIs) may also be inappropriate in some cases as these medications are recommended to be used with caution in older adults and SSRIs should be avoided in those with a history of falls or fractures according to the Beers Criteria and also antidepressants may not be effective for depression associated with dementia .
Deprescribing is defined as the process of withdrawal of an inappropriate medication, supervised by a healthcare professional with the goal of managing polypharmacy and improving outcomes . The high exposure to PIMs in our study indicates that older adults in residential care could be an appropriate target group for deprescribing. This may not only benefit the residents, but may also lead to cost saving. In addition to the direct costs of PIMs there are additional indirect costs of managing associated adverse drug events. Deprescribing of PIMs may reduce both direct and indirect costs associated with their use. However, substitution with alternatives, such as non-pharmacological interventions, carries its own costs. Future studies should investigate the cost-effectiveness of deprescribing PIMs in residential care. Several randomised controlled trials have found positive effects of interventions in residential care facilities (e.g., educational interventions for clinical staff, medication reviews) in reducing the use of inappropriate medications; however, the effects on clinical outcomes remain unclear [30,31,32,33,34,35,36].
In Australia, around AUD$9 billion is spent annually (2011–2012 figure) by the government on residential aged care services and in the same year there were 187,941 residential aged care places . Furthermore, medications constitute a high proportion of all direct health costs in residential aged care . Based on the numbers of people exposed to a PIM, the average amount spent on PIMs per participant in this study, and the feasibility of stopping PIMS in practice , reducing exposure to half of these PIMs could result in an annual direct saving in medication costs of approximately AUD$38 million in Australia.
Participants who were living in a home-like model of residential care had a lower risk of incurring any costs due to PIMs over the one year period compared to those living in standard models of care. The prevalence and costs of PIMs in different models of residential care have not been previously explored. Residential care facilities which offer a home-like model of care have been shown to favourably impact quality of life, behavioural symptoms and emotional well-being of the residents [8, 10, 40, 41]. Reasons for lower exposure to PIMs in these settings cannot be determined in the current study, but a possible improvement in quality of life seen in the residents may lead to fewer behavioural symptoms and a lower proportion of PIM use in these settings. However, there was no difference in NPI scores between those who had and had not been exposed to a PIM. Also, staff in alternative models of residential care may be able to accommodate and manage changed behaviours more effectively using alternative approaches than is possible in standard models of care. Further research is needed to clarify the effectiveness of home-like care models on different outcomes for residents and staff . Those that had not been exposed to a PIM were more likely to have a diagnosis of dementia and this may be due to a higher proportion of people living with dementia residing in a home-like model of care, but the definitive reason for this association could not be determined in this study.
Strengths and limitations
This study collected comprehensive data on an older population living in residential care, including a high prevalence of people with cognitive impairment and dementia. The dispensing data were collected from electronic records held by the individual pharmacies used by the facilities and they are inclusive of all of the medications dispensed to the individuals over the study period.
We were unable to include PIMs based on diagnosis (apart from cognitive impairment and dementia); therefore only medications which are PIMs for all older adults were included so this may be an underestimate of the actual costs of PIMs in this population. There is also a difference in formularies between Australia and the US where the Beers Criteria were developed as some medications are not available in Australia and some medications were added to adapt the Beers Criteria to an Australian setting (4% of PIMs were additional medications added). Polypharmacy has been identified as a risk factor for exposure to PIMs . However, we could not directly examine the prevalence of polypharmacy in this study as we examined 12 month period prevalence of medications rather than point prevalence.
Facilities which have adopted a home-like model of care as described in this study were all located in one state in Australia and these facilities are specifically designed for people with dementia. However, we have adjusted for many potential confounding factors including PAS-Cog scores and NPI scores between the models of care.
Exposure to PIMs is very common amongst older adults with a high prevalence of cognitive impairment and dementia permanently residing in aged care facilities. The financial cost of PIMs is high and has the potential to be lowered by reducing the prevalence of PIMs in this setting. Facilities which had adopted a home-like model of residential care were less likely to incur costs due to PIMs. Further research should investigate whether deprescribing of PIMs in older people in residential facilities could lead to cost savings and improvements in outcomes such as mortality, hospitalization and quality of life.
Behavioural and psychological symptoms of dementia
Dispensed Price for Maximum Quantity
Investigating Services Provided in the Residential Environment for Dementia
Psychogeriatric Assessment Scale-Cognitive Impairment Scale
Pharmaceutical Benefits Scheme
Potentially inappropriate medication
Cooper JA, Cadogan CA, Patterson SM, Kerse N, Bradley MC, Ryan C, Hughes CM. Interventions to improve the appropriate use of polypharmacy in older people: a Cochrane systematic review. BMJ Open. 2015;5(12):e009235.
Scott IA, Hilmer SN, Reeve E, Potter K, Le Couteur D, Rigby D, Gnjidic D, Del Mar CB, Roughead EE, Page A, et al. Reducing inappropriate polypharmacy: the process of deprescribing. JAMA Intern Med. 2015;175(5):827–34.
American Geriatrics Society. American Geriatrics Society 2015 updated beers criteria for potentially inappropriate medication use in older adults. J Am Geriatr Soc. 2015;63(11):2227–46.
Lau DT, Kasper JD, Potter DE, Lyles A. Potentially inappropriate medication prescriptions among elderly nursing home residents: their scope and associated resident and facility characteristics. Health Serv Res. 2004;39(5):1257–76.
Hyttinen V, Jyrkka J, Valtonen H. A systematic review of the impact of potentially inappropriate medication on health care utilization and costs among older adults. Med Care. 2016;54(10):950–64.
Heider D, Matschinger H, Meid AD, Quinzler R, Adler J-B, Günster C, Haefeli WE, König H-H. Health service use, costs, and adverse events associated with potentially inappropriate medication in old age in Germany: retrospective matched cohort study. Drugs Aging. 2017;34(4):289-301.
Morin L, Laroche ML, Texier G, Johnell K. Prevalence of potentially inappropriate medication use in older adults living in nursing homes: a systematic review. J Am Med Dir Assoc. 2016;17(9):862. e861-869
Zimmerman S, Bowers BJ, Cohen LW, Grabowski DC, Horn SD, Kemper P, Collaborative TR. New evidence on the green house model of nursing home care: synthesis of findings and implications for policy, practice, and research. Health Serv Res. 2016;51(Suppl 1):475–96.
World report on ageing and health. http://www.who.int/ageing/events/world-report-2015-launch/en/. Accessed 8 Jan 2018.
Ausserhofer D, Deschodt M, De Geest S, van Achterberg T, Meyer G, Verbeek H, Sjetne IS, Malinowska-Lipien I, Griffiths P, Schluter W, et al. “There's no place like home”: a scoping review on the impact of homelike residential care models on resident-, family-, and staff-related outcomes. J Am Med Dir Assoc. 2016;17(8):685–93.
PBS Publications Archive. http://www.pbs.gov.au/info/publication/schedule/archive. Accessed 8 Jan 2018.
DPMQ. https://dev.pbs.gov.au/docs/glossary/DPMQ.html. Accessed 8 Jan 2018.
Foreign exchange rates, monthly rates. https://www.ato.gov.au/Tax-professionals/TP/1-July-2015-to-30-June-2016/. Accessed 8 Jan 2018.
Fleming R, Purandare N. Long-term care for people with dementia: environmental design guidelines. Int Psychogeriatr. 2010;22(7):1084–96.
Verbeek H, Zwakhalen SM, van Rossum E, Ambergen T, Kempen GI, Hamers JP. Dementia care redesigned: effects of small-scale living facilities on residents, their family caregivers, and staff. J Am Med Dir Assoc. 2010;11(9):662–70.
Lawton MP. The physical environment of the person with Alzheimer's disease. Aging Ment Health. 2001;5(Suppl 1):S56–64.
Cohen-Mansfield J, Marx MS, Regier NG, Dakheel-Ali M. The impact of personal characteristics on engagement in nursing home residents with dementia. Int J Geriatr Psychiatry. 2009;24(7):755–63.
Palm R, Kohler K, Schwab CG, Bartholomeyczik S, Holle B. Longitudinal evaluation of dementia care in German nursing homes: the “DemenzMonitor” study protocol. BMC Geriatr. 2013;13:123.
Buntin MB, Zaslavsky AM. Too much ado about two-part models and transformation?: comparing methods of modeling Medicare expenditures. J Health Econ. 2004;23(3):525–42.
Smith VA, Preisser JS, Neelon B, Maciejewski ML. A marginalized two-part model for semicontinuous data. Stat Med. 2014;33(28):4891–903.
Somers M, Rose E, Simmonds D, Whitelaw C, Calver J, Beer C. Quality use of medicines in residential aged care. Aust Fam Physician. 2010;39(6):413–6.
Vieira de Lima TJ, Garbin CA, Garbin AJ, Sumida DH, Saliba O. Potentially inappropriate medications used by the elderly: prevalence and risk factors in Brazilian care homes. BMC Geriatr. 2013;13:52.
Morgan SG, Hunt J, Rioux J, Proulx J, Weymann D, Tannenbaum C. Frequency and cost of potentially inappropriate prescribing for older adults: a cross-sectional study. CMAJ Open. 2016;4(2):E346–51.
Bradley MC, Fahey T, Cahir C, Bennett K, O'Reilly D, Parsons C, Hughes CM. Potentially inappropriate prescribing and cost outcomes for older people: a cross-sectional study using the Northern Ireland enhanced prescribing database. Eur J Clin Pharmacol. 2012;68(10):1425–33.
Desilets AR, Asal NJ, Dunican KC. Considerations for the use of proton-pump inhibitors in older adults. Consult Pharm. 2012;27(2):114–20.
Hilmer SN, Gnjidic D. Rethinking psychotropics in nursing homes. Med J Aust. 2013;198(2):77.
Guideline Adaptation Committee. Clinical practice guidelines and principles of Care for People with dementia. Sydney: Guideline Adaptation Committee; 2016.
Brodaty H, Draper B, Low L. Behavioural and psychological symptoms of dementia: a seven-tiered model of service delivery. MJA. 2003;178(5):231–4.
Reeve E, Gnjidic D, Long J, Hilmer S. A systematic review of the emerging definition of ‘deprescribing’ with network analysis: implications for future research and clinical practice. Br J Clin Pharmacol. 2015;80(6):1254–68.
Garcia-Gollarte F, Baleriola-Julvez J, Ferrero-Lopez I, Cuenllas-Diaz A, Cruz-Jentoft AJ. An educational intervention on drug use in nursing homes improves health outcomes resource utilization and reduces inappropriate drug prescription. J Am Med Dir Assoc. 2014;15(12):885–91.
Gallagher PF, O'Connor MN, O'Mahony D. Prevention of potentially inappropriate prescribing for elderly patients: a randomized controlled trial using STOPP/START criteria. Clin Pharmacol Ther. 2011;89(6):845–54.
Dalleur O, Boland B, Losseau C, Henrard S, Wouters D, Speybroeck N, Degryse JM, Spinewine A. Reduction of potentially inappropriate medications using the STOPP criteria in frail older inpatients: a randomised controlled study. Drugs Aging. 2014;31(4):291–8.
Pitkala KH, Juola AL, Kautiainen H, Soini H, Finne-Soveri UH, Bell JS, Bjorkman M. Education to reduce potentially harmful medication use among residents of assisted living facilities: a randomized controlled trial. J Am Med Dir Assoc. 2014;15(12):892–8.
Potter K, Flicker L, Page A, Etherton-Beer C. Deprescribing in frail older people: a randomised controlled trial. PLoS One. 2016;11(3):e0149984.
Crotty M, Whitehead C, Rowett D, Halbert J, Weller D, Finucane P, Esterman A. An outreach intervention to implement evidence based practice in residential care: a randomized controlled trial [ISRCTN67855475]. BMC Health Serv Res. 2004;4(1):6.
Thiruchelvam K, Hasan SS, Wong PS, Kairuz T. Residential aged care medication review to improve the quality of medication use: a systematic review. J Am Med Dir Assoc. 2017;18(1):87. e81-87.e14
Department of Health and Ageing, Australian Government. 2011-12. Report on the Operation of the Aged Care Act. https://www.agedcarecrisis.com/images/ar/ROACA-2011-2012.pdf. Accessed 8 Jan 2018.
Gnanamanickam ES, Dyer SM, Milte R, Harrison SL, Liu E, Easton T, Bradley C, Bilton R, Shulver W, Ratcliffe J, et al. Direct health and residential care costs of people living with dementia in Australian residential aged care. Int J Geriatr Psychiatry. 2018. Epub ahead of print.
Nishtala PS, Hilmer SN, McLachlan AJ, Hannan PJ, Chen TF. Impact of residential medication management reviews on drug burden index in aged-care homes: a retrospective analysis. Drugs Aging. 2009;26(8):677–86.
Chenoweth L, Forbes I, Fleming R, King MT, Stein-Parbury J, Luscombe G, Kenny P, Jeon YH, Haas M, Brodaty H. PerCEN: a cluster randomized controlled trial of person-centered residential care and environment for people with dementia. Int Psychogeriatr. 2014;26(7):1147–60.
Kane RA, Lum TY, Cutler LJ, Degenholtz HB, Yu TC. Resident outcomes in small-house nursing homes: a longitudinal evaluation of the initial green house program. J Am Geriatr Soc. 2007;55(6):832–9.
The authors sincerely thank the INSPIRED study participants and their family members for their participation and interest in the study. The assistance of facility staff, careworker researchers, facility pharmacists and data collectors in each state is gratefully acknowledged for their efforts. Members of the study team Mrs. Anne Whitehouse, Mrs. Angela Basso, Ms. Keren McKenna, Dr. Wendy Shulver and Dr. Rebecca Bilton are thanked for their input into the INSPIRED study management, data collection and data coordination.
The Department of Human Services are acknowledged as the data custodians for the PBS datasets.
This study is supported by funding provided by the National Health and Medical Research Council (NHMRC) Partnership Centre on Dealing with Cognitive and Related Functional Decline in Older People (grant no. GNT9100000). The contents of the published materials are solely the responsibility of the Administering Institution, Flinders University, and the individual authors identified, and do not reflect the views of the NHMRC or any other Funding Bodies or the Funding Partners. The funding partner played no role in the collection, analysis, and interpretation of data and in the design or writing of this manuscript.
Availability of data and materials
The datasets used and analysed during the current study are available from the corresponding author on reasonable request and subject to appropriate ethics approvals.
Ethics approval and consent to participate
The study received ethical approval from the Flinders Social and Behavioural Research Ethics Committee (Approval numbers 6732 and 6753) and written consent was obtained from all participants (self-consent or proxy) as approved by the ethics committee. Proxy consent was obtained when a participant had a Pas-Cog score of ≥ 10 indicating moderate to severe cognitive impairment.
Consent for publication
This study and the researchers are supported by funding provided by the National Health and Medical Research Council (NHMRC) Partnership Centre on Dealing with Cognitive and Related Functional Decline in Older People (grant no. GNT9100000). This Partnership Centre includes Australian aged care residential service providers: HammondCare, Helping Hand Aged Care and Brightwater Care Group. Although these industry partners did not provide funding to this study they did provide advice and access to their facilities. SMD was employed in the development of Clinical Practice Guidelines for Dementia in Australia which includes recommendations relating to the use of pharmaceuticals in dementia. The authors declare no other conflicts of interest.
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.