Hovstadius B, et al. Increasing polypharmacy - an individual-based study of the Swedish population 2005-2008. BMC Clin Pharmacol. 2010;10:16.
Article
PubMed
PubMed Central
Google Scholar
Onder G, et al. Advanced age and medication prescription: More years, less medications? A nationwide report from the Italian medicines agency. J Am Med Director Assoc. 2016;17(2):168-72.
Flaherty JH, et al. Polypharmacy and hospitalization among older home care patients. J Gerontol A Biol Sci Med Sci. 2000;55(10):M554–9.
Article
CAS
PubMed
Google Scholar
Gregg D, Goldschmidt-Clermont PJ. Platelets and cardiovascular disease. Circulation. 2003;108(13):e88–90.
Article
CAS
PubMed
Google Scholar
Silber S. Evidence-based management of ST-segment elevation myocardial infarction (STEMI): latest guidelines of the European Society of Cardiology (ESC) 2010. [German] Evidenzbasiertes Vorgehen beim ST-Strecken-Hebungsinfarkt (STEMI): Neueste Leitlinien der Europaischen Gesellschaft fur Kardiologie (ESC) 2010. Herz. 2010;35(8):558–65.
Article
CAS
PubMed
Google Scholar
Perk J, et al. European guidelines on cardiovascular disease prevention in clinical practice (version 2012). The fifth joint task force of the European Society of Cardiology and other societies on cardiovascular disease prevention in clinical practice (constituted by representatives of nine societies and by invited experts). G Ital Cardiol (Rome). 2013;14(5):328–92.
Google Scholar
Lüllmann H, Mohr K, Hein L. Pharmakologie und Toxikologie. Georg Thieme Verlag. 2010;207(9):314.
Patrono C, et al. Low-dose aspirin for the prevention of atherothrombosis. N Engl J Med. 2005;353(22):2373–83.
Article
CAS
PubMed
Google Scholar
Howard RL, et al. Which drugs cause preventable admissions to hospital? A systematic review. Br J Clin Pharmacol. 2007;63(2):136–47.
Article
CAS
PubMed
Google Scholar
Kongkaew C, et al. Risk factors for hospital admissions associated with adverse drug events. Pharmacotherapy. 2013;33(8):827–37.
Article
PubMed
Google Scholar
Davies EC, et al. Emergency re-admissions to hospital due to adverse drug reactions within 1 year of the index admission. Br J Clin Pharmacol. 2010;70(5):749–55.
Article
PubMed
PubMed Central
Google Scholar
Salvi F, et al. Adverse drug events as a cause of hospitalization in older adults. Drug Saf. 2012;35(1):29–45.
Article
PubMed
Google Scholar
Fick DM, et al. Updating the beers criteria for potentially inappropriate medication use in older adults: results of a US consensus panel of experts. Arch Intern Med. 2003;163(22):2716–24.
Article
PubMed
Google Scholar
Sorensen HT, et al. Risk of upper gastrointestinal bleeding associated with use of low-dose aspirin. Am J Gastroenterol. 2000;95(9):2218–24.
Article
CAS
PubMed
Google Scholar
Franchini M. Hemostasis and aging. Crit Rev Oncol Hematol. 2006;60(2):144–51.
Article
PubMed
Google Scholar
Van Spall HG, et al. Eligibility criteria of randomized controlled trials published in high-impact general medical journals: a systematic sampling review. JAMA. 2007;297(11):1233–40.
Article
PubMed
Google Scholar
Boyd CM, et al. Clinical practice guidelines and quality of care for older patients with multiple comorbid diseases: implications for pay for performance. JAMA. 2005;294(6):716–24.
Article
CAS
PubMed
Google Scholar
Sonnichsen A, et al. Polypharmacy in chronic diseases-reduction of inappropriate medication and adverse drug events in older populations by electronic decision support (PRIMA-eDS): study protocol for a randomized controlled trial. Trials. 2016;17(1):57.
Article
PubMed
PubMed Central
Google Scholar
Martinez YM, R.-G.A., Reeves D, Ediriweera de Silva RE, Esmail A, Kunnamo I, Rieckert A, Sommerauer C, Sönnichsen A, A set of systematic reviews to help reduce inappropriate prescribing to older people: study protocol. BMC Geriatrics. 2017;17(1).
Shea BJ, et al. Development of AMSTAR: a measurement tool to assess the methodological quality of systematic reviews. BMC Med Res Methodol. 2007;7:10.
Article
PubMed
PubMed Central
Google Scholar
Shea BJ, et al. AMSTAR is a reliable and valid measurement tool to assess the methodological quality of systematic reviews. J Clin Epidemiol. 2009;62(10):1013–20.
Article
PubMed
Google Scholar
Higgins JPT, G.S., (editors). Cochrane handbook for systematic reviews of interventions. Version 5.1.0 [updated March 2011] The Cochrane Collaboration, 2011. Available from http://handbook-5-1.cochrane.org/. 2011. Last accessed 18 Aug 2017.
Critical Appraisal Skills Programme. 11 questions to help you make sense of case control study. 2013; Available from: https://hhs.hud.ac.uk/lqsu/Useful/critap/Case%20Control%20Study%20Checklist/CASP-Case-Control-Study-Checklist-31.05.13.pdf. Accessed 18 Aug 2018.
Critical Appraisal Skills Programme. 12 questions to help you make sense of cohort study. 2013; Available from: https://hhs.hud.ac.uk/lqsu/Useful/critap/Cohort%20Study%20Checklist/CASPCohort-Study-Checklist-31.05.13.pdf. Accessed 18 Aug 2017.
Guyatt GH, et al. Going from evidence to recommendations. BMJ. 2008;336(7652):1049–51.
Article
PubMed
PubMed Central
Google Scholar
Guyatt GH, et al. What is “quality of evidence” and why is it important to clinicians? BMJ. 2008;336(7651):995–8.
Article
PubMed
PubMed Central
Google Scholar
Guyatt GH, et al. GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. BMJ. 2008;336(7650):924–6.
Article
PubMed
PubMed Central
Google Scholar
Baigent C, et al. Aspirin in the primary and secondary prevention of vascular disease: collaborative meta-analysis of individual participant data from randomised trials. Lancet. 2009;373(9678):1849–60.
Article
PubMed
Google Scholar
He J, et al. Aspirin and risk of hemorrhagic stroke: a meta-analysis of randomized controlled trials. JAMA. 1998;280(22):1930–5.
Article
CAS
PubMed
Google Scholar
Aguilar MI, Hart R, Pearce LA. Oral anticoagulants versus antiplatelet therapy for preventing stroke in patients with non-valvular atrial fibrillation and no history of stroke or transient ischemic attacks. Cochrane Database Syst Rev. 2007;(3):Cd006186.
Kjeldsen SE, et al. Influence of gender and age on preventing cardiovascular disease by antihypertensive treatment and acetylsalicylic acid. The HOT study. Hypertension optimal treatment. J Hypertens. 2000;18(5):629–42.
Article
CAS
PubMed
Google Scholar
Silagy CA, et al. Adverse effects of low-dose aspirin in a healthy elderly population. Clin Pharmacol Ther. 1993;54(1):84–9.
Article
CAS
PubMed
Google Scholar
Ogawa H, et al. Low-dose aspirin for primary prevention of atherosclerotic events in patients with type 2 diabetes: a randomized controlled trial. JAMA. 2008;300(18):2134–41.
Article
CAS
PubMed
Google Scholar
Group, E.A.F.T.S. Secondary prevention in non-rheumatic atrial fibrillation after transient ischaemic attack or minor stroke. EAFT (European Atrial fibrillation trial) study group. Lancet. 1993;342(8882):1255–62.
Google Scholar
Ikeda Y, et al. Low-dose aspirin for primary prevention of cardiovascular events in Japanese patients 60 years or older with atherosclerotic risk factors: a randomized clinical trial. JAMA. 2014;312(23):2510–20.
Article
PubMed
Google Scholar
Huynh T, et al. Aspirin, warfarin, or the combination for secondary prevention of coronary events in patients with acute coronary syndromes and prior coronary artery bypass surgery. Circulation. 2001;103(25):3069–74.
Article
CAS
PubMed
Google Scholar
Taylor FC, Cohen H, Ebrahim S. Systematic review of long term anticoagulation or antiplatelet treatment in patients with non-rheumatic atrial fibrillation. BMJ. 2001;322(7282):321–6.
Article
CAS
PubMed
PubMed Central
Google Scholar
Segal JB, et al. Prevention of thromboembolism in atrial fibrillation: a meta-analysis of trials of anticoagulants and antiplatelet drugs. J Gen Intern Med. 2000;15(1):56–67.
Article
CAS
PubMed
PubMed Central
Google Scholar
Hart RG, et al. Antithrombotic therapy to prevent stroke in patients with atrial fibrillation: a meta-analysis. Ann Intern Med. 1999;131(7):492–501.
Article
CAS
PubMed
Google Scholar
Hart RG, Pearce LA, Aguilar MI. Meta-analysis: antithrombotic therapy to prevent stroke in patients who have nonvalvular atrial fibrillation. Ann Intern Med. 2007;146(12):857–67.
Article
PubMed
Google Scholar
Dogliotti A, Paolasso E, Giugliano RP. Current and new oral antithrombotics in non-valvular atrial fibrillation: a network meta-analysis of 79 808 patients. Heart. 2014;100(5):396–405.
Article
CAS
PubMed
Google Scholar
Cooper NJ, et al. Mixed comparison of stroke prevention treatments in individuals with nonrheumatic atrial fibrillation. Arch Intern Med. 2006;166(12):1269–75.
Article
PubMed
Google Scholar
Andersen LV, et al. Warfarin for the prevention of systemic embolism in patients with non-valvular atrial fibrillation: a meta-analysis. Heart. 2008;94(12):1607–13.
Article
CAS
PubMed
Google Scholar
Assiri A, et al. Mixed treatment comparison meta-analysis of aspirin, warfarin, and new anticoagulants for stroke prevention in patients with nonvalvular atrial fibrillation. Clin Ther. 2013;35(7):967–984. e2.
Article
CAS
PubMed
Google Scholar
Lip GY, Edwards SJ. Stroke prevention with aspirin, warfarin and ximelagatran in patients with non-valvular atrial fibrillation: a systematic review and meta-analysis. Thromb Res. 2006;118(3):321–33.
Article
CAS
PubMed
Google Scholar
Cameron C, et al. Systematic review and network meta-analysis comparing antithrombotic agents for the prevention of stroke and major bleeding in patients with atrial fibrillation. BMJ Open. 2014;4(6):e004301.
Article
PubMed
PubMed Central
Google Scholar
Liu X, et al. Warfarin compared with aspirin for older Chinese patients with stable coronary heart diseases and atrial fibrillation complications. Int J Clin Pharmacol Ther. 2014;52(6):454–9.
Article
CAS
PubMed
Google Scholar
Burton C, et al. The safety and adequacy of antithrombotic therapy for atrial fibrillation: a regional cohort study. Br J Gen Pract. 2006;56(530):697–702.
PubMed
PubMed Central
Google Scholar
Aguilar MI, Hart R. Antiplatelet therapy for preventing stroke in patients with non-valvular atrial fibrillation and no previous history of stroke or transient ischemic attacks. Cochrane Database Syst Rev. 2005;19(4):CD001925.
Google Scholar
Uchiyama S, et al. Aspirin for stroke prevention in elderly patients with vascular risk factors: Japanese primary prevention project. Stroke. 2016;47(6):1605–11.
Article
CAS
PubMed
Google Scholar
Wiviott SD, et al. Prasugrel versus clopidogrel in patients with acute coronary syndromes. N Engl J Med. 2007;357(20):2001–15.
Article
CAS
PubMed
Google Scholar
Zhou YH, et al. Effects of combined aspirin and clopidogrel therapy on cardiovascular outcomes: a systematic review and meta-analysis. PLoS One. 2012;7(2):e31642.
Article
CAS
PubMed
PubMed Central
Google Scholar
Diener HC, et al. Aspirin and clopidogrel compared with clopidogrel alone after recent ischaemic stroke or transient ischaemic attack in high-risk patients (MATCH): randomised, double-blind, placebo-controlled trial. Lancet. 2004;364(9431):331–7.
Article
CAS
PubMed
Google Scholar
Gandhi S, et al. Comparison of dual-antiplatelet therapy to mono-antiplatelet therapy after Transcatheter aortic valve implantation: systematic review and meta-analysis. Can J Cardiol. 2015;31(6):775–84.
Article
PubMed
Google Scholar
Leonardi-Bee J, et al. Dipyridamole for preventing recurrent ischemic stroke and other vascular events: a meta-analysis of individual patient data from randomized controlled trials. Stroke. 2005;36(1):162–8.
Article
CAS
PubMed
Google Scholar
Halkes PH, et al. Dipyridamole plus aspirin versus aspirin alone in secondary prevention after TIA or stroke: a meta-analysis by risk. J Neurol Neurosurg Psychiatry. 2008;79(11):1218–23.
Article
CAS
PubMed
Google Scholar
Warkentin AE, et al. Bleeding risk in randomized controlled trials comparing warfarin and aspirin: a systematic review and meta-analysis. J Thromb Haemost. 2012;10(4):512–20.
Article
CAS
PubMed
Google Scholar
Britton M, Helmers C, Samuelsson K. High-dose acetylsalicylic acid after cerebral infarction. A Swedish cooperative study. Stroke. 1987;18(2):325–34.
Article
Google Scholar
Sam C, et al. Warfarin and aspirin use and the predictors of major bleeding complications in atrial fibrillation (the Framingham heart study). Am J Cardiol. 2004;94(7):947–51.
Article
CAS
PubMed
Google Scholar
Coleman CI, et al. Effect of pharmacological therapies for stroke prevention on major gastrointestinal bleeding in patients with atrial fibrillation. Int J Clin Pract. 2012;66(1):53–63.
Article
CAS
PubMed
Google Scholar
Connolly BJ, et al. Aspirin therapy and risk of subdural hematoma: meta-analysis of randomized clinical trials. J Stroke Cerebrovasc Dis. 2013;22(4):444–8.
Article
PubMed
Google Scholar
Stroke prevention in atrial fibrillation investigators. Warfarin versus aspirin for prevention of thromboembolism in atrial fibrillation: Stroke Prevention in Atrial Fibrillation II Study. Lancet. 1994;343(8899):687–91.
Lin L, et al. Clinical and safety outcomes of oral Antithrombotics for stroke prevention in Atrial fibrillation: a systematic review and network meta-analysis. J Am Med Dir Assoc. 2015;16(12):1103.e1–1103.e19.
Article
Google Scholar
The American geriatrics society 2015 beers criteria update expert panel. American geriatrics society 2015 updated beers criteria for potentially inappropriate medication use in older adults. J Am Geriatr Soc. 2015;63(11):2227-46.
American geriatrics society 2012 beers criteria update expert panel. American geriatrics society updated beers criteria for potentially inappropriate medication use in older adults. J Am Geriatr Soc. 2012;60(4):616–31.
O'Mahony D, et al. STOPP/START criteria for potentially inappropriate prescribing in older people: version 2. Age Ageing. 2015;44(2):213–8.
Article
PubMed
Google Scholar
Piepoli MF, et al. 2016 European guidelines on cardiovascular disease prevention in clinical practice: the sixth joint task force of the European Society of Cardiology and Other Societies on cardiovascular disease prevention in clinical practice (constituted by representatives of 10 societies and by invited experts) developed with the special contribution of the European Association for Cardiovascular Prevention & rehabilitation (EACPR). Atherosclerosis. 2016;252:207–74.
Article
CAS
PubMed
Google Scholar
ASPREE Investigator Group. Study design of ASPirin in Reducing Events in the Elderly (ASPREE): a randomized, controlled trial. Contemp Clin Trials. 2013;36(2)555–64.
Slabaugh SL, et al. Prevalence and risk of polypharmacy among the elderly in an outpatient setting: a retrospective cohort study in the Emilia-Romagna region, Italy. Drugs Aging. 2010;27(12):1019–28.
Article
PubMed
Google Scholar