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Table 9 Characteristics of participants in included SR/MA

From: Effectiveness and patient safety of platelet aggregation inhibitors in the prevention of cardiovascular disease and ischemic stroke in older adults – a systematic review

Reference Setting/country/ethnicity Male sex Age Comorbidity Number of coincident medications Functional status/Frailty level Cognitive status
Aguilar 2005 [49] Denmark, Spain, USA 62% Mean age 70 years Not reported Not reported Not reported Not reported
Aguilar 2007 [30] Asia, Austria, Denmark, Greece, Netherlands, South America, South Africa, Spain, USA Ranged from 45 to 66% Mean age 64–75 years Not reported Not reported Not reported Not reported
Andersen 2013 [43] Not reported Not reported Mean age 63.3–81.5 years Most of the participants had at least one risk factor for cerebral embolism: previous MI, hypertension, diabetes mellitus, heart failure and/or stroke Not reported Not reported Not reported
Assiri 2013 [44] Not reported 58.7% Mean age 71 years Not reported Not reported Not reported Not reported
Baigent 2009 [28] Asia, Italy, UK, USA Not reported Subgroup ≥65 years Not reported Not reported Not reported Not reported
Cameron 2014 [46] America, Asia, Canada, Denmark, Japan, UK, Not reported Mean age 62–83 years Prior stroke 3%–55% Not reported Not reported Not reported
Coleman 2012 [56] Denmark, France, Italy, Japan, Netherlands, Spain, USA Ranged from 41%–100% Mean age 65–75 years Not reported Not reported Not reported Not reported
Cooper 2006 [42] Asia, Australia, Canada, Denmark, Italy, Japan, Netherlands, Spain, Sweden, USA Ranged from 32%–100% Mean age 64–80.5 years Previous stroke 0–100% Not reported Not reported Not reported
Connolly 2013 [61] Japan, Sweden, USA 41% Mean age 57 years, subgroup ≥70 years Not reported Not reported Not reported Not reported
Dogliotti 2014 [41] Canada, Japan, UK, USA Ranged from 46 to 100% Mean age 64–83 years Hypertension 31.5–90.5%, diabetes mellitus 4–40%, previous myocardial infarction 8.6–19%, heart failure 5–69.5%, previous TIA/stroke 3.7–70% Not reported Not reported Not reported
Gandhi 2015 [54] France, Italy, UK 43% Mean age 82.2 years Hypertension 99%, dyslipidemia 52%, coronary heart disease 47%, diabetes mellitus 24%, atrial fibrillation 18%, chronic kidney disease 8.1%, previous myocardial infarction 13% Not reported Not reported Not reported
Halkes 2008 [56] Canada, France, USA Ranged from 63 to 64% Mean age 65 years Hypertension 58%, diabetes mellitus 16–17%, ischaemic heart disease 25% Not reported Not reported Not reported
Hart 2007 [40] China, Japan, USA 75% Mean age 71 years Not reported Not reported Not reported Not reported
Hart 1999 [39] Canada, UK, USA Ranged from 62 to 71% Mean age 69–71 years Hypertension 45–46%, previous TIA/stroke 20–40% Not reported Not reported Not reported
He 1998 (JAMA) [29] Australia, Canada, Denmark, France, Sweden, UK. USA, 99% white 86% Mean age 59, subgroup ≥64 years Hypertension 24%, hyperlipidaemia 11%, smoking 21% Not reported Not reported Not reported
Leonardi-Bee 2005 [55] Canada, France, Italy, Spain, USA 60% Mean age 65.4 Not reported Not reported Not reported Not reported
Liang Lin 2015 [63] Asia, Canada, China, Denmark, Hong Kong, Israel, Japan, Netherlands, Spain, Sweden, UK, USA NRSs 56%, RCTs 62% Mean Age 71.5 years, subgroup-analysis age ≥ 75 years Hypertension 17–94%, chronic heart failure 1–70%, diabetes mellitus 3–45%, prior TIA/stroke 3–55% Not reported Not reported Not reported
Lip 2006 [45] Canada, Denmark, Italy, Netherlands, USA Not reported Mean age 64–80 years Not reported Not reported Not reported Not reported
Segal 2000 [38] Canada, Denmark, Netherlands, Sweden, USA Ranged from 24%–100% Mean age 66–80 years Diabetes mellitus 8%–32%, congestive heart failure 9%–71%, hypertension 32%–58% Not reported Not reported Not reported
Taylor 2001 [37] Denmark, Italy, Netherlands, USA Not reported Mean age 64–80 years Not reported Not reported Not reported Not reported
Warkentin 2012 [57] Canada, Denmark, Greece, UK, Spain, USA Ranged from 47 to 89% Mean age 62–83 years Not reported Not reported Not reported Not reported
Zhou 2012 [52] Canada, USA Ranged from 58.2–89.4% Mean age 61.7–71 years, subgroup-analysis age ≥ 65 years Not reported Not reported Not reported Not reported
  1. Note: NRS Numerical Rating Scale, RCT: randomized controlled trial, TIA: transient ischaemic attack