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Table 10 Characteristics of participants in included RCTs

From: Effectiveness and patient safety of platelet aggregation inhibitors in the prevention of cardiovascular disease and ischemic stroke in older adults – a systematic review

Reference Setting/country/ethnicity Male sex Age Comorbidity Number of coincident medications Functional status/frailty level Cognitive status
Britton 1987 [58] Sweden ASA: 67%, placebo: 58% Mean age 68 years, subgroup analysis age ≥ 68 years ASA/placebo: hypertension 48%/45%, diabetes mellitus 15%/18%, smoking 48%/57%, hyperlipidaemia 2%/3%, angina 20%/15%, myocardial infarction 11%/9%, heart failure 15%/17%, atrial fibrillation 6%/8%, claudication 9%/8%, previous TIA 8%/8%, previous cerebral infarction 6%/6%, previous other strokes 5%/5% Not reported Capable of walking by themselves and without aphasia 61%, severely disabled 39% Not reported
Diener 2004 [53] 28 countries Placebo: 63%, intervention: 63% Placebo + clopidogrel: mean age 66.1 years, 54% older than 65 years. ASA + clopidogrel: mean age 66.5 years, 56% older than 65 years, subgroup analysis age ≥ 65 years Placebo + clopidogrel/ASA + clopidogrel: hypertension 78%/78%, diabetes mellitus 68%/68%, hypercholesterinaemia 57%/56%, smoking 47%/48%, previous ischaemic stroke 26%/27%, previous TIA 19%/19%, previous myocardial infarction 5%/5%, angina pectoris 12%/13%, symptomatic peripheral arterial disease 10%/10% Not reported Not reported Not reported
EAFT 1993 [34] Israel OAC: 55%, ASA: 59%, placebo: 53% OAC: mean age 71 years, 80% older than 65 years. ASA: mean age 73 years, 84% older than 65 years, placebo: mean age 73 years, 84% older than 65 years Warfarin/ASA/placebo: Multiple strokes in the year prior to randomisation 19%/22%/24%, hypertension 43%/49%/47%, diabetes mellitus 12%/13%/13%, hypercholesterinaemia 12%/10%/7%, smoking 19%/20%/18%, angina pectoris 11%/11%/11%, myocardial infarction 7%/7%/9%, congestive heart failure 8%/11%/12%, minor stroke 8%/8%/6% Not reported Not reported Not reported
Huynh 2001 [36] Canada ASA + placebo: 82.2%, warfarin + placebo: 86.4%, ASA + warfarin: 70.7% ASA + placebo: mean age 68 years, 61% older than 65 years. Warfarin + placebo: mean age 67 years, 57% older than 65 years.
ASA + warfarin: mean age 66 years, 53% older than 65 years, subgroup analysis age ≥ 65 years
ASA + placebo/warfarin + placebo/warfarin + ASA: hypertension 34.8%/37.8%/38.6%, prior myocardial infarction 56.5%/62.2%/72.7%, current smoking 17.8%/31.1%/20.5%, hyperlipidaemia 43.5%/62.2%/68.2%, diabetes mellitus 17.4%/15.6%/25% ASA + placebo/warfarin + placebo/warfarin + ASA: β-blockers 71.7%/57.8%/70.5%, calcium antagonists 52.2%/55.6%/54.5%, nitrates 63%/64.4%/75%, lipid-lowering agents 37%/42.2%/36.4%, ACE inhibitors 15.3%/35.6%/22.7%, antiarrhythmic agents 2.2%/6.8%/4.6%, diuretics 11%/26.7%/34.1% Not reported Not reported
Ikeda 2014 [35] Japan ASA 42.3%, control 42.4% ASA: mean age 70.6 years, 82% older than 65 years. Control: mean age 70.5 years, 81% older than 65 years ASA/control: BMI >25 36.6%/35.9%, hypertension 84.9%/84.8%, dyslipidaemia 72%/71.8%, diabetes mellitus 33.9%/33.9%, smoking 13.3%/12.9% Not reported Not reported Not reported
Kjeldsen 2000 (HOT) [31] 26 countries 53% Men: mean age 60.8 years, 28% older than 65 years. Women: mean age 62.3 years, 36% older than 65 years, subgroup analysis age ≥ 65 years Men/women: smoking 21.2%/10%, diabetes mellitus 7.8%/8.2%, previous cardiovascular disease 9.8%/7.4% Men/women: calcium antagonists 45.2%/37.9%, β-blockers 28.3%/28.2%, ACE-inhibitors 39.3%/37.2%, diuretics 29.8%/36.4% Not reported Not reported
Liu 2014 [47] China Warfarin: 60.8%, ASA: 60.0% Warfarin: mean age 84.8 years. ASA: mean age 84.4 years, 100% older than 65 years Warfarin/ASA: hypertension 39.2%/38%, diabetes mellitus 21.6%/22%, smoking 25.5%/24%, previous myocardial infarction 15.7%/14%, angina pectoris 84.3%/86% Warfarin/ASA: β-blockers 7.8%/6%, statins 11.2%/16%, ACE-inhibitors or ARB 9.8%/12% Not reported Not reported
Ogawa 2008 [33] Japan ASA: 56%, non-ASA: 53% ASA: mean age 65 years, 50% older than 65 years. NonASA group: mean age 64 years, 46% older than 65 years, subgroup analysis age ≥ 65 years ASA/non-ASA: smoking 23%/19%, hypertension 59%/57%, dyslipidaemia 54%/52%, diabetes mellitus 100%/100% ASA/non-ASA: sulfonylureas 58%/56%, α-glukosidase-inhibitors 33%/32%, biguanides 13%/15%, insulin 13%/13%, thiazolidines 5%/5%, calcium antagonists 35%/34%, angiotensin-II antagonists 21%/21%, ACE-inhibitors 14%/15%, β-blockers 6%/7%, α-blockers 4%/3%, statins 26%/26% Not reported Not reported
Silagy 1993 [32] Australia, Germany, USA ASA: 48.6%, placebo: 49.6% Mean age 73 years, 100% older than 65 years ASA/placebo: smoking 4.5%/7.1% Not reported Not reported Not reported
Uchiyama 2016 [50] Japan ASA: 42.3% no ASA: 42.4% ASA: mean age 70.6 years, 82% older than 65 years. No ASA: 70.5 years, 81% older than 65 years ASA/no ASA: hypertension 84.9%/84.8%, dyslipidaemia 72%/71.8%, diabetes mellitus 33.9%/33.9%, BMI >25 36.6%/35.9%, smoking 13.3%/12.9% Not reported Not reported Not reported
Wiviott 2007 [51] 30 countries Prasugrel: 75%, clopidogrel 73% Mean age 61 years, 13% older than 75 years, subgroup analysis age ≥ 65 years Prasugrel/clopidogrel: hypertension 64%/64%, hypercholesterolemia 56%/56%, diabetes mellitus 23%/23%, smoking 38%/38%, previous myocardial infarction 18%/18%, previous CABG 8%/7% Prasugrel/clopidogrel: heparin 66%/65%, LMWH 9%/8%, bivalirudin 3%/3%, glycoprotein IIb/IIIa–receptor antagonist 54%/55%, ACE inhibitors 76%/75%, β-blockers 88%/88%, statin 92%/92%, calcium antagonists 18%/17%, ASA 99%/99% Not reported Not reported
  1. Note: ASA acetylsalicylic acid, BMI Body Mass Index, CABG coronary artery bypass graft, LMWH low molecular weight heparin, OAC oral anticoagulation, TIA transient ischaemic attack