Symptom burden in community-dwelling older people with multimorbidity: a cross-sectional study
BMC Geriatrics volume 15, Article number: 1 (2015)
Globally, the population is ageing and lives with several chronic diseases for decades. A high symptom burden is associated with a high use of healthcare, admissions to nursing homes, and reduced quality of life. The aims of this study were to describe the multidimensional symptom profile and symptom burden in community-dwelling older people with multimorbidity, and to describe factors related to symptom burden.
A cross-sectional study including 378 community-dwelling people ≥ 75 years, who had been hospitalized ≥ 3 times during the previous year, had ≥ 3 diagnoses in their medical records. The Memorial Symptom Assessment Scale was used to assess the prevalence, frequency, severity, distress and symptom burden of 31 symptoms. A multiple linear regression was performed to identify factors related to total symptom burden.
The mean number of symptoms per participant was 8.5 (4.6), and the mean total symptom burden score was 0.62 (0.41). Pain was the symptom with the highest prevalence, frequency, severity and distress. Half of the study group reported the prevalence of lack of energy and a dry mouth. Poor vision, likelihood of depression, and diagnoses of the digestive system were independently related to the total symptom burden score.
The older community-dwelling people with multimorbidity in this study suffered from a high symptom burden with a high prevalence of pain. Persons with poor vision, likelihood of depression, and diseases of the digestive system are at risk of a higher total symptom burden and might need age-specific standardized guidelines for appropriate management.
Chronic conditions among older people represent some of the largest health care challenges of this century, and one which will affect both the socioeconomics and the health care system. Globally, the population is ageing and people can now live with several chronic diseases for decades. Chronic diseases tend to increase with old age. An international systematic review reported that approximately 62% of all the people aged between 65–74 years, and 81.5% of people above 85 years suffer from multiple chronic diseases. A co-occurrence of ≥2 diseases, where at least one is chronic, is defined as multimorbidity. Multimorbidity is a condition with a high impact on functional impairment and quality of life[5, 6], and is a condition that often results in a variety of different symptoms.
In a number of studies, older people have been reported to suffer from various symptoms. These reports have been based on measurements of a single symptom such as depression fatigue, sleep disorder or pain. Other studies have been based on only one symptom dimension, usually intensity or severity[12, 13]. The use of a multidimensional approach with the aforementioned dimensions is advocated both in research and clinical practice. A multidimensional assessment may also serve as a sufficient patient-reported outcome and it has been shown to be a sensitive tool to measure the effectiveness of interventions. Symptom burden is a complex concept that goes beyond the scoring of any symptom instrument. To persons suffering from an advanced disease the impact of symptoms is often a well-known. In an older population, high symptom burden is associated with increased health care utilization, frequent visits to the emergency department, hospitalization, admissions to nursing homes, and reduced quality of life[20, 21]. Symptom burden has been defined in different ways. In this study symptom burden is defined as "the subjective, quantifiable prevalence, frequency, and severity of symptoms placing a physiological burden on patients and producing multiple negative, physical, and emotional patient responses".
Earlier studies within the research field of multidimensional symptoms have usually been conducted on specific chronic diseases, for example chronic obstructive pulmonary disease (COPD), heart failure (HF) or renal disease[20, 21, 23], and there is a paucity of studies focusing on multidimensional symptoms in older persons with multimorbidity. Existing guidelines for disease management are disease-specific, and they are not designed for people with multimorbidity. If we set out to reduce the impact of diseases by reducing the symptom frequency, minimizing symptom severity, and relieving symptom distress it is essential to look at and assess the total symptom burden, not just one disease at the time.
The aims of this study were to describe the multidimensional symptom profile and symptom burden of community-dwelling older people with multimorbidity. An additional aim was to describe which factors are related to symptom burden.
This is a cross-sectional study using baseline data from a randomized controlled trial intended to include community-dwelling older people with multimorbidity and who had a great need for health care during the preceding year.
Participants were recruited from one municipality through the patient administrative system of the County Council. Norrkoping is a middle-sized city, (120 000) in the south-east of Sweden, where approximately 9% of the inhabitants are ≥75 years. Inclusion criteria were: people ≥ 75 years, who had been hospitalized ≥ 3 times during the previous year, who had ≥ 3 diagnoses in their medical records according to the International classification of diseases (ICD-10) and who lived at home. The only exclusion criterion was if participants were already living in a nursing home. Eight hundred forty-four older people were invited to participate; of those, 79 were excluded since they had moved to a nursing home just before the study started, 26 were deceased, 32 could not be reached, and 304 declined to participate. Out of the 403 that were willing to participate, in 22 cases written informed consent was missing and they were therefore excluded. In the present study, only those who had completed the symptom assessment instrument were included; in total 378 eligible participants. The flow-chart of the study is visualized in Figure 1.
An invitation letter explaining the purpose of the study was sent to the eligible older people. They were then contacted by telephone, and those who gave oral informed consent were scheduled for an appointment at their home for protocolled directed interviews during which written consent was obtained. All data were collected with protocol-guided interviews, performed by specially trained registered nurses or occupational therapists between February 2011 and December 2011. The study followed the ethical guidelines given in the declaration of Helsinki and was approved by the regional ethical review board in Linkoping (Dnr. 2011/41-31).
Symptom prevalence, symptom experience and symptom burden were assessed using the Memorial Symptom Assessment Scale (MSAS). MSAS includes a large number of commonly occurring symptoms and assesses the prevalence of 32 symptoms. It considers symptoms experienced during the preceding week in terms of three dimensions - frequency, severity and distress - for 24 symptoms, and two dimensions - severity and distress - for eight symptoms. The format for responses is as follows. The prevalence of each symptom is answered by yes/no: frequency on a four-point scale - rarely, occasionally, frequently or almost constantly; severity on a four-point scale - slight, moderate, severe, or very severe; and distress on a five-point scale - not at all, a little bit, somewhat, quite a bit or very much. For clarity of reporting, we used the terms ‘high frequency’, ‘high severity’ and ‘high distress’ for the two highest scores of each symptom dimension. One item dealing with sexual interest or activity was excluded from the original instrument prior to the data collection. The data collector did not feel comfortable asking the old and often lonely people a question about sex. This left the instrument with 31 symptoms. The coding of the instrument was based upon the instruction of the original authors. The symptom burden score was calculated as a mean score of frequency, severity and distress of each symptom. The total symptom burden score per patient (TMSAS) is the mean of all 31 symptom burden scores. The MSAS was originally conducted to assess symptoms in people with cancer but has since been tested and evaluated on people with different chronic diseases[20, 21, 27]. The MSAS is validated and has been used in a Swedish context[28, 29]. The Cronbach’s alpha coefficient for TMSAS in this study was 0.82.
Background data collected in this study included age, gender, current marital status, living situation, next of kin, education level, use of tobacco and alcohol, problems with vision, hearing, and body mass index (BMI). Cognitive decline was measured by the Mini-Mental State Examination (MMSE), which is a validated 30-point brief questionnaire test that is used to screen for cognitive impairment. In this test, 24 points or more is considered as normal cognitive function, 18–23 is mild–moderate cognitive dysfunction, and <18 indicates severe cognitive dysfunction. The likelihood of depression was assessed by using the Geriatric Depression Scale (GDS-15), which is a validated self-reported instrument. Data on the participants’ medical diagnoses were provided by the ‘Data Care Warehouse’, which is a population-based, administrative database run by the County Council.
The statistical analysis is described by frequencies and percentages for categorical variables, and continuous data by means and standard deviations (SD) for normally distributed data. To be able to compare results from this study with previous research, MSAS symptom burden scores are presented as mean (SD) even though the variables were often skewed. A multiple linear regression analysis was performed to determine independent associations between TMSAS and the background characteristics from Table 1. The multiple model was built by entering those variables that had univariate statistical significance with a p < 0.05 in the correlation, retaining those variables with p < 0.05 in the final regression model. All two-way interactions were tested in the model. Data were analyzed using PASW Statistical (SPSS) version 20. The significance level was set at p ≤ 0.05.
The mean age of the participants was 82 (4.8) years, with an almost equal distribution of men (52%) and women (48%) (Table 1). Significant differences were found both regarding gender and age between people who agreed to participate (n = 381) and those who declined, could not be reached, had moved to nursing home, did not provide informed consent or had recently died (n = 461). People who agreed to participate were slightly younger than the non-participants 82 (4.8) vs.83 (5.4) years (p = 0.024) and more men than women accepted the invitation to participate (p = 0.039).
In total, 51% of participants lived alone and 81% had an educational level consisting of elementary school. Approximately one-third (28%) reported problems with vision, with or without glasses and (34%) reported problems with hearing, with or without hearing device. In total, 8% currently smoked and 7% drank alcohol on a daily basis. The mean score on the MMSE was 26 (3.2), and 20% of the participants had a score below 24 that could indicate cognitive dysfunction. With regard to depression we found that 32% scored equal or higher than 5 on the GDS, indicating the likelihood of depression (Table 1).
Participants in this study had three or more medical diagnoses in their medical record. Almost all participants (96%) had at least one disease listed in ICD chapter 9, diseases of the circulatory system. Participants also had diseases from ICD chapter 9 relating to the musculoskeletal system (83%), diseases of the digestive system (60%) and diseases of the eye and adnexa (58%) (Table 1).
The mean number of symptoms per patient (total prevalence) was 8.5 (4.6), 30% of the participants reported 10 co-occurring symptoms or more, and three participants (0.8%) reported no symptoms at all. In the total group of respondents, pain was the symptom with the highest prevalence (67%). Half of the participants (47-51%) reported dry mouth, lack of energy, numbness and tingling in the hands and feet. Almost four out of ten (36-42%) experienced problems with feeling drowsy, dizziness, shortness of breath, difficulty sleeping, feeling sad, and worrying (Table 2).
Pain was the symptom reported with the highest frequency score, with four out of 10 participants (43%) reporting that the symptom had occurred frequently or almost constantly during the preceding week. Nausea and vomiting were reported by less than 5% (Table 2).
Pain was a symptom that most participants reported as severe. One-third (31%) of the participants gave the symptom a high severity score (severe or very severe). Difficulty sleeping and lack of energy were reported by 17-21% respectively as being "severe or very severe." (Table 2).
Pain and a lack of energy were reported with a high symptom distress score (quite a bit or very much distress) by 35% and 25% of the respondents respectively. Numbness and tingling in the hands and feet, dizziness, shortness of breath and difficulty sleeping were reported by 14–16% of the participants as causing high symptom distress (Table 2).
Symptom burden is reported for participants who experienced the symptoms during the preceding week and not for the total group of 378 participants. For 29 of 31 assessed symptoms, patients who reported the respective symptom had a mean score of ≥ 2.0, and seven symptoms were reported to have a mean symptom burden of more than 2.6 (Table 3). Pain had the highest symptom burden score; the 248 patients who reported having pain had a mean symptom burden of 2.8 (0.68). With regard to pain we found that 45% of the 248 participants who reported pain had a symptom burden score of ≥ 3.0 (Table 3).
Factors related to symptom burden
For the total group of participants the total symptom burden (TMSAS) had a mean (SD) score of 0.62 (0.41). TMSAS was significantly correlated with sex (rs = -0.16), with women reporting a higher score than men. TMSAS was also significantly correlated vision (rs = -0.14) and hearing (rs = -0.10), with participants with poor vision or hearing reporting higher TMSAS scores. TMSAS was correlated with risk of depression (rs = 0.57), diseases of mental and behavioral disorder (rs = 0.21), diseases of the digestive system (rs = 0.16) and diseases of the nervous system (rs = 0.11). In the multiple linear regression, TMSAS was independently related to poor vision (beta = -0.153), risk of depression (beta = 0.566), and diseases of the digestive system (beta = 0.109). The R2 for this model was 0.38, indicating that 38% of the variance of TMSAS could be explained by these three predictors (Table 4).
There is a lack of knowledge concerning the multidimensional symptom profile and symptom burden in older people with multimorbidity. An important finding of this study was that older community-dwelling people with multimorbidity suffer a considerable symptom burden, with a mean of eight symptoms per person, and some people even reporting 10 symptoms. Almost seven out of ten older people suffered from pain. Pain was also the symptom with the highest frequency, severity, and distress and had the highest symptom burden score of all 31 symptoms. Three factors were found to be independently associated with total symptom burden: poor vision, likelihood of depression, and diseases of the digestive system.
Almost seven out of 10 participants in this study had experienced pain during the preceding week, which is a high number but in line with some other studies in which community-dwelling older people reported a pain prevalence of between 20 to 79%[31, 32]. As reflected by the high symptom burden, our findings show that pain causes older people a considerable amount of suffering. This group of older people living in a home had a burden of pain that was comparable to the scores of hospitalized cancer patients near the end of life, which was not something we had expected. Earlier studies described pain as underdiagnosed and undertreated[31, 33] and found that, irrespective of clinical diagnosis, 25% of older people do not receive analgesic treatment for pain, and people older than 85 are even less likely to receive it. At the same time, polypharmacy is a huge problem within the group of older people with multimorbidity; inappropriate drug intake causes complications and symptoms, leading to repeated visits to the emergency department and hospitalization. There has been a lack of age-specific standardized management guidelines for geriatric pain, and health professionals have felt that multimorbidity complicates appropriate management. Just recently, new guidance for treating pain in the elderly was published.
In addition to pain, lack of energy, difficulty swallowing, "I don't look like myself", difficulty sleeping, problems with urination, and diarrhea had a high symptom burden in those who experienced them. These symptoms seem rather non-specific, that is, not related to one specific medical diagnosis, and are not always recognized as being important. However, earlier studies have shown that older people with a high symptom burden have a poorer quality of life and higher use of health services[18, 19]. To facilitate and improve symptom management, health care providers should not only look at and assess disease-specific symptoms but also take general symptoms into consideration.
We also found that poor vision, likelihood of depression, and diseases of the digestive system were associated with total symptom burden. It is known that people in a depressive mood experience a higher symptom burden than those who are not. Earlier studies have confirmed the association between depression and pain. If recognized and treated, depression is often reversible, but if left untreated, depression may result in the onset of physical, cognitive, functional, and social impairment, as well as decreased quality of life, and higher mortality. The independent relationship between poor vision and the total symptom burden scale has not previously been described, but other studies have reported that people with poor hearing or vision are more likely to experience disability, and that there are associations between poor vision, poor hearing and depression. Earlier studies have shown that people with diseases of the digestive system have a lower health-related quality of life[41, 42] and that the severity of the gastro-intestinal symptoms and health-related quality of life are associated. Reflecting on the high symptom burden in multimorbid older people, we observe that in our current health care system most care is organized from a single disease perspective, an arrangement into which older people with multimorbidity do not quite seem to fit. These older people have reported feeling unwelcome or even like a burden when they need to seek care. However, health care providers still have the responsibility to give patients optimal support to restore or at least achieve an acceptable level of symptom relief. A routine of a broad assessment of symptoms and symptom burden (not restricted to the disease-specific burden) might lead to better symptom management[19, 45] which could maintain independence and functional ability, and sustain or improve quality of life for older people with multimorbidity.
Strengths and limitations
The strength of this study is that all data are assessed by protocol-guided interviews, leaving us with little missing data. However, there is still a risk that the older people’s symptom experience or burden have been underestimated since studies have shown that when questionnaires are self-administered instead of interviewer-administered the scores tend to be higher, so this should be taken into consideration when the scores are interpreted[46, 47]. We also realize that this is a rather small cross-sectional study, with participants recruited from only one city and with a higher percentage of men than in the general population. The result of this study cannot be generalized to all community-dwelling older people, since they represent a unique group with many diseases. Nevertheless, the result ought to be generalizable to groups with similar conditions and living in a similar context. Another limitation of this study is the lack of data on diseases from all the ICD chapters. Data on diseases would have made it possible to identify disease clusters and use these to predict TMSAS or to describe the symptom experience of specific clusters. However, we still believe that although clustering of diseases is important and an area of interest for future studies, our results bring forward the unique perspective of an elderly population with several diseases living with a high symptom burden.
A large proportion of the older people with multimorbidity living in the community suffer from a high symptom burden and a high prevalence of pain. These people have an unmet need for optimized treatment focusing on the assessment, management and maintenance of the total symptom burden. People with poor vision, likelihood of depression and diseases of the digestive system are at risk of facing a higher symptom burden and might need age-specific standardized guidelines for appropriate management.
Body mass index
Mini-mental state examination
Geriatric depression scale
International classification of diseases.
EU: The European Commission: Eurostat: Population Projections. 2011. available at:http://epp.eurostat.ec.europa.eu/statistics_explained/index.php/Population_projections
WHO: Innovative Care for Chronic Conditions: Building Blocks for Actions. http://whqlibdoc.who.int/hq/2002/WHO_NMC_CCH_02.01.pdf
Salive ME: Multimorbidity in Older Adults.Epidemiol Rev 2013,35(1):75–83. 10.1093/epirev/mxs009
Le Reste JY, Nabbe P, Manceau B, Lygidakis C, Doerr C, Lingner H, et al.: The European General Practice Research Network presents a comprehensive definition of multimorbidity in family medicine and long term care, following a systematic review of relevant literature.J Am Med Dir Assoc 2013,14(5):319–25. 10.1016/j.jamda.2013.01.001
Marengoni A, Angleman S, Melis R, Mangialasche F, Karp A, Garmen A, et al.: Aging with multimorbidity: a systematic review of the literature.Ageing Res Rev 2011,10(4):430–9. 10.1016/j.arr.2011.03.003
Barnett K, Mercer SW, Norbury M, Watt G, Wyke S, Guthrie B: Epidemiology of multimorbidity and implications for health care, research, and medical education: a cross-sectional study.Lancet 2012,380(9836):37–43. 10.1016/S0140-6736(12)60240-2
Walke LM, Byers AL, Gallo WT, Endrass J, Fried TR: The association of symptoms with health outcomes in chronically ill adults.J Pain Symptom Manage 2007,33(1):58–66. 10.1016/j.jpainsymman.2006.07.013
Drayer RA, Mulsant BH, Lenze EJ, Rollman BL, Dew MA, Kelleher K, et al.: Somatic symptoms of depression in elderly patients with medical comorbidities.Int J Geriatr Psychiatry 2005,20(10):973–82. 10.1002/gps.1389
Mollaoglu M, Fertelli TK, Tuncay FO: Fatigue and disability in elderly patients with chronic obstructive pulmonary disease (COPD).Arch Gerontol Geriatr 2011,53(2):e93–8. 10.1016/j.archger.2010.07.001
Cuellar NG, Rogers AE, Hisghman V, Volpe SL: Assessment and treatment of sleep disorders in the older adult.Geriatr Nurs 2007,28(4):254–64. 10.1016/j.gerinurse.2007.01.017
Brown ST, Kirkpatrick MK, Swanson MS, McKenzie IL: Pain experience of the elderly.Pain Manag Nurs 2011,12(4):190–6. 10.1016/j.pmn.2010.05.004
Hareendran A, Leidy NK, Monz BU, Winnette R, Becker K, Mahler DA: Proposing a standardized method for evaluating patient report of the intensity of dyspnea during exercise testing in COPD.Int J Chron Obstruct Pulmon Dis 2012, 7:345–55.
Lukas A, Barber JB, Johnson P, Gibson SJ: Observer-rated pain assessment instruments improve both the detection of pain and the evaluation of pain intensity in people with dementia.Eur J Pain 2013,17(10):1558–68.
Cleeland CS, Reyes-Gibby CC: When is it justified to treat symptoms? Measuring symptom burden.Oncology (Williston Park) 2002,16(9):64–70.
Zambroski CH, Moser DK, Bhat G, Ziegler C: Impact of symptom prevalence and symptom burden on quality of life in patients with heart failure.Eur J Cardiovasc Nurs 2005,4(3):198–206. 10.1016/j.ejcnurse.2005.03.010
Cleeland CS: Symptom Burden: Multiple Symptoms and Their Impact as Patient-Reported Outcomes.J Natl Cancer Inst Monogr 2007, 37:16.
Selby D, Gill A, Chakraborty A: What is symptom burden: A qualitative exploration of patient definitions.J Palliat Care 2012,28(2):83–9.
Salanitro AH, Hovater M, Hearld KR, Roth DL, Sawyer P, Locher JL, et al.: Symptom burden predicts hospitalization independent of comorbidity in community-dwelling older adults.J Am Geriatr Soc 2012,60(9):1632–7. 10.1111/j.1532-5415.2012.04121.x
Sheppard KD, Brown CJ, Hearld KR, Roth DL, Sawyer P, Locher JL, et al.: Symptom burden predicts nursing home admissions among older adults.J Pain Symptom Manage 2013,46(4):591–7. 10.1016/j.jpainsymman.2012.10.228
Blinderman CD, Homel P, Andrew Billings J, Tennstedt S, Portenoy RK: Symptom distress and quality of life in patients with advanced chronic obstructive pulmonary disease.J Pain Symptom Manage 2009,38(1):115–23. 10.1016/j.jpainsymman.2008.07.006
Blinderman CD, Homel P, Billings JA, Portenoy RK, Tennstedt SL: Symptom distress and quality of life in patients with advanced congestive heart failure.J Pain Symptom Manage 2008,35(6):594–603. 10.1016/j.jpainsymman.2007.06.007
Gapstur RL: Symptom burden: a concept analysis and implications for oncology nurses.Oncol Nurs Forum 2007,34(3):673–80. 10.1188/07.ONF.673-680
Murtagh FE, Addington-Hall J, Edmonds P, Donohoe P, Carey I, Jenkins K, et al.: Symptoms in the month before death for stage 5 chronic kidney disease patients managed without dialysis.J Pain Symptom Manage 2010,40(3):342–52. 10.1016/j.jpainsymman.2010.01.021
Hughes LD, Hughes LD, McMurdo MET, Guthrie B: Guidelines for people not for diseases: the challenges of applying UK clinical guidelines to people with multimorbidity.Age Ageing 2013,42(1):62–9. 10.1093/ageing/afs100
Mazya AL, Eckerblad J, Jaarsma T, Hellström I, Krevers B, Milberg A, et al.: The Ambulatory Geriatric Assessment – a Frailty Intervention Trial (AGe-FIT) – A randomised controlled trial aimed to prevent hospital readmissions and functional deterioration in high risk older adults: A study protocol.Eur Geriatr Med 2013,4(4):242–7. 10.1016/j.eurger.2013.05.004
Portenoy RK, Thaler HT, Kornblith AB, Lepore JM, Friedlander-Klar H, Kiyasu E, et al.: The Memorial Symptom Assessment Scale: an instrument for the evaluation of symptom prevalence, characteristics and distress.Eur J Cancer 1994,30A(9):1326–36.
Tranmer JE, Heyland D, Dudgeon D, Groll D, Squires-Graham M, Coulson K: Measuring the symptom experience of seriously ill cancer and noncancer hospitalized patients near the end of life with the Memorial Symptom Assessment Scale.J Pain Symptom Manage 2003,25(5):420–9. 10.1016/S0885-3924(03)00074-5
Pettersson G, Bertero C, Unosson M, Borjeson S: Symptom prevalence, frequency, severity, and distress during chemotherapy for patients with colorectal cancer.Support Care Cancer 2014,22(5):1171–9. 10.1007/s00520-013-2069-z
Browall M, Kenne Sarenmalm E, Nasic S, Wengstrom Y, Gaston-Johansson F: Validity and reliability of the Swedish version of the Memorial Symptom Assessment Scale (MSAS): an instrument for the evaluation of symptom prevalence, characteristics, and distress.J Pain Symptom Manage 2013,46(1):131–41. 10.1016/j.jpainsymman.2012.07.023
Sheik J, Yesavage J: Geriatric Depression Scale (GDS): recent evidence and development of a shorter version.Clin Gerontol 1986, 5:165–72. 10.1300/J018v05n01_09
Abdulla A, Adams N, Bone M, Elliott AM, Gaffin J, Jones D, et al.: Guidance on the management of pain in older people.Age Ageing 2013,42(Suppl 1):i1–57.
Bergh I, Steen G, Waern M, Johansson B, Odén A, Sjöström B, et al.: Pain and its relation to cognitive function and depressive symptoms: A Swedish population study of 70-year-old men and women.J Pain Symptom Manage 2003,26(4):903–12. 10.1016/S0885-3924(03)00329-4
Landi F, Onder G, Cesari M, Gambassi G, Steel K, Russo A, et al.: Pain management in frail, community-living elderly patients.Arch Intern Med 2001,161(22):2721–4. 10.1001/archinte.161.22.2721
Mannucci PM, Nobili A, Investigators R: Multimorbidity and polypharmacy in the elderly: lessons from REPOSI.Intern Emerg Med 2014,9(7):723–34. 10.1007/s11739-014-1124-1
Rastogi R, Meek BD: Management of chronic pain in elderly, frail patients: finding a suitable, personalized method of control.Clin Interv Aging 2013, 8:37–46.
Lenz ER, Pugh LC, Milligan RA, Gift A, Suppe F: The middle-range theory of unpleasant symptoms: an update.ANS Adv Nurs Sci 1997,19(3):14–27. 10.1097/00012272-199703000-00003
Landi F, Onder G, Cesari M, Russo A, Barillaro C, Bernabei R: Pain and its relation to depressive symptoms in frail older people living in the community: an observational study.J Pain Symptom Manage 2005,29(3):255–62. 10.1016/j.jpainsymman.2004.06.016
Marc LG, Raue PJ, Bruce ML: Screening performance of the 15-item geriatric depression scale in a diverse elderly home care population.Am J Geriatr Psychiatry 2008,16(11):914–21. 10.1097/JGP.0b013e318186bd67
Royall DR, Schillerstrom JE, Piper PK, Chiodo LK: Depression and mortality in elders referred for geriatric psychiatry consultation.J Am Med Dir Assoc 2007,8(5):318–21. 10.1016/j.jamda.2006.12.018
Huang CQ, Dong BR, Lu ZC, Yue JR, Liu QX: Chronic diseases and risk for depression in old age: a meta-analysis of published literature.Ageing Res Rev 2010,9(2):131–41. 10.1016/j.arr.2009.05.005
Simren M, Svedlund J, Posserud I, Bjornsson ES, Abrahamsson H: Health-related quality of life in patients attending a gastroenterology outpatient clinic: functional disorders versus organic diseases.Clin Gastroenterol Hepatol 2006,4(2):187–95. 10.1016/S1542-3565(05)00981-X
Frank L, Kleinman L, Rentz A, Ciesla G, Kim JJ, Zacker C: Health-related quality of life associated with irritable bowel syndrome: comparison with other chronic diseases.Clin Ther 2002,24(4):675–89. discussion 674 10.1016/S0149-2918(02)85143-8
Ekdahl AW, Andersson L, Friedrichsen M: They do what they think is the best for me. Frail elderly patients’ preferences for participation in their care during hospitalization.Patient Educ Couns 2010,80(2):233–40. 10.1016/j.pec.2009.10.026
Dodd MJ S, Facione N, Faucett J, Froelicher ES, Humphreys J, Lee K, et al.: Advancing the science of symptom management.J Adv Nurs 2001,33(5):668–76. 10.1046/j.1365-2648.2001.01697.x
Chaudhry SI, Murphy TE, Gahbauer E, Sussman LS, Allore HG, Gill TM: Restricting symptoms in the last year of life: a prospective cohort study.JAMA Intern Med 2013,173(16):1534–40. 10.1001/jamainternmed.2013.8732
de Waal MW, van der Weele GM, van der Mast RC, Assendelft WJ, Gussekloo J: The influence of the administration method on scores of the 15-item Geriatric Depression Scale in old age.Psychiatry Res 2012,197(3):280–4. 10.1016/j.psychres.2011.08.019
Wajnberg A, Ornstein K, Zhang M, Smith KL, Soriano T: Symptom burden in chronically ill homebound individuals.J Am Geriatr Soc 2013,61(1):126–31. 10.1111/jgs.12038
SCB Statistics Sweden, Population statistics. http://www.scb.se/
The pre-publication history for this paper can be accessed here: http://www.biomedcentral.com/1471-2318/15/1/prepub
We thank all the participants and their families included in this study. We also thank the interviewers and recruiters for their assistance and support during the data collection. The first author received funding for this study from: the Faculty of Health sciences, Linkoping University; the county council of Ostergotland; the Signe and Olof Wallenius trust fund; Solstickan; and the Swedish Association of Geriatric Medicine with support from Mundipharma. The funding sources were independent and had no influence on the study.
The authors declare that they have no competing interests.
Study Design: AE, JE, MU, A-BW, AM, BK, TJ. Analysis: JE, KT, MU, A-BW, TJ. Manuscript preparation: JE, KT, MU, TJ. All authors performed a critical revision of the manuscript and approved the final version to be published JE, KT, AE, MU, A-BW, AM, BK, TJ. The manuscript has been read and approved by all authors named therein.
About this article
Cite this article
Eckerblad, J., Theander, K., Ekdahl, A. et al. Symptom burden in community-dwelling older people with multimorbidity: a cross-sectional study. BMC Geriatr 15, 1 (2015). https://doi.org/10.1186/1471-2318-15-1