Global Health and Ageing (2011). WHO (Online) Available at: http://www.who.int/ageing/publications/global_health/en/. Accessed: March 03 2015.
Ensrud KE, Ewing SK, Taylor BC, et al. Frailty and risk of falls, fracture, and mortality in older women: the study of osteoporotic fractures. J Gerontol A Biol Sci Med Sci. 2007;62:744–51.
Al Snih S, Graham JE, Ray LA, et al. Frailty and incidence of activities of daily living disability among older Mexican Americans. J Rehabil Med. 2009;41:892–7.
Boyd CM, Xue QL, Simpson CF, et al. Frailty, hospitalization, and progression of disability in a cohort of disabled older women. Am J Med. 2005;118:1225–31.
Chang Y-W, Chen W-L, Lin F-G, et al. Frailty and its impact on health-related quality of life: a cross-sectional study on elder community-dwelling preventive health service users. PLoS One. 2012;7(5):e38079. doi:10.1371/journal.pone.0038079.
Puts MTE, Lips P, Deeg DJH. Sex Differences in the Risk of Frailty for Mortality Independent of Disability and Chronic Diseases. J Am Geriatr Soc. 2005;53:40–47.
Gale CR, Cooper C, Deary IJ, Aihie Sayer A. Psychological well-being and incident frailty in men and women: the English Longitudinal Study of Ageing. Psychol Med. 2014;44:697–706.
Collard RM, Boter H, Schoevers RA, et al. Prevalence of frailty in community-dwelling older persons: a systematic review. J Am Geriatr Soc. 2012;60(8):1487–92.
Rodriguez-Manas L, Feart C, Mann G, et al. Searching for an Operational Definition of Frailty: A Delphi Based Consensus Statement. The frailty operative definition-consensus conference project. J Gerontol A Biol Sci Med Sci. 2013;68(1):62–7.
Clegg A, Young J, Iliffe S, et al. Frailty in elderly people. Lancet. 2013;381:752–62.
Fried LP, Ferrucci L, Darer J, et al. Untangling the concepts of disability, frailty, and comorbidity: implications for improved targeting and care. J Gerontol: Med Sci. 2004;59:255–63.
Lang PO, Michel JP, Zekry D. Frailty syndrome: a transitional state in a dynamic process. Gerontology. 2009;55:539–49.
Fried LP, Tangen CM, Walston J, et al. Frailty in older adults: evidence for a phenotype. J Gerontol: Med Sci. 2001;56A(3):146–56.
Mitnitski AB, Mogilner AJ, Rockwood K. Accumulation of deficits as a proxy measure of aging. Sci World. 2001;1:323–36. doi:10.1100/tsw.2001.58. Available from: ISSN 1532–2246; [Accessed: 03/10/2014].
Sternberg S, Wershof Schwartz A, Karunananthan S, et al. The identification of frailty: a systematic literature review. J Am Geriatr Soc. 2011;59:2129–38.
Clegg A, Rogers L, Young J. Diagnostic test accuracy of simple instruments for identifying frailty in community-dwelling older people: a systematic review. Age Ageing. 2015;44(1):148–52.
Pijpers E, Ferreira I, Stehouwer CD, Nieuwenhuijzen Kruseman AC. The frailty dilemma. Review of the predictive accuracy of major frailty scores. Eur J Intern Med. 2012;23(2):118–23.
Drubbel I, Numans ME, Kranenburg G, et al. Screening for frailty in primary care: A systematic review of the psychometric properties of the frailty index in community-dwelling older people. BMC Geriatr. 2014;14:27.
de Vries NM, Staal JB, van Ravensberg CD, et al. Outcome instruments to measure frailty: a systematic review. Ageing Res Rev. 2011;10(1):104–14.
Bouillon K, Kivimaki M, Hamer M, et al. Measures of frailty in population-based studies: an overview. BMC Geriatr. 2013;13:64.
Terwee CB, Mokkink LB, Knol DL, et al. Rating the methodological quality in systematic reviews of studies on measurement properties: A scoring system for the COSMIN checklist. Qual Life Res. 2012;21:651–7.
Mokkink LB, Terwee CB, Patrick DL, et al. The COSMIN study reached international consensus on taxonomy, terminology, and definitions of measurement properties for health-related patient-reported outcomes. J Clin Epidemol. 2010;63:737–45.
Mokkink LB, Terwee CB, Patrick DL, et al. The COSMIN checklist for assessing the methodological quality of studies on measurement properties of health status measurement instruments: an international Delphi study. Qual Life Res. 2010;19:539–49.
Moher D, Liberati A, Tetzlaff J, Altman DG, The PRISMA Group. Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement. BMJ. 2009;339:b2535. doi:10.1136/bmj.b2535.
Ravaglia G, Forti P, Lucicesare A, et al. Development of an easy prognostic score for frailty outcomes in the aged. Age Ageing. 2008;37(2):161–6.
Rockwood K, Stadnyk K, MacKnight C, et al. A brief clinical instrument to classify frailty in elderly people. Lancet. 1999;353(9148):205–6.
Kenig J, Zychiewicz B, Olszewska U, Richter P. Screening for frailty among older patients with cancer that qualify for abdominal surgery. J Geriatr Oncol. 2015;6(1):52–9.
Freiheit EA, Hogan DB, Eliasziw M, et al. Development of a frailty index for patients with coronary artery disease. J Am Geriatr Soc. 2010;58(8):1526–31.
Kamaruzzaman S, Ploubidis GB, Fletcher A, Ebrahim S. A reliable measure of frailty for a community dwelling older population. Health Qual Life Outcomes. 2010;8:123.
Goldstein J, Hubbard RE, Moorhouse P, et al. The validation of a care partner-derived frailty index based upon comprehensive geriatric assessment (CP-FI-CGA) in emergency medical services and geriatric ambulatory care. Age Ageing. 2015;44(2):327–30.
Rockwood K, Song X, MacKnight C, et al. A global clinical measure of fitness and frailty in elderly people. Can Med Assoc J. 2005;173(5):489–95.
Rockwood K, Abeysundera MJ, Mitnitski A. How should we grade frailty in nursing home patients? J Am Med Dir Assoc. 2007;8(9):595–603.
Mitnitski A, Fallah N, Rockwood MR, Rockwood K. Transitions in cognitive status in relation to frailty in older adults: a comparison of three frailty measures. J Nutr Health Aging. 2011;15(10):863–7.
Studenski S, Hayes RP, Leibowitz RQ, et al. Clinical global impression of change in physical frailty: development of a measure based on clinical judgment. J Am Geriatr Soc. 2004;52(9):1560–6.
Sundermann S, Dademasch A, Praetorius J, et al. Comprehensive assessment of frailty for elderly high-risk patients undergoing cardiac surgery. Eur J Cardiothorac Surg. 2011;39(1):33–7.
Sundermann S, Dademasch A, Rastan A, Praetorius J, Rodriguez H, Walther T, et al. One-year follow-up of patients undergoing elective cardiac surgery assessed with the Comprehensive Assessment of Frailty test and its simplified form. Interact Cardiovasc Thorac Surg. 2011;13(2):119–23.
Sundermann SH, Dademasch A, Seifert B, et al. Frailty is a predictor of short- and mid-term mortality after elective cardiac surgery independently of age. Interact Cardiovasc Thorac Surg. 2014;18(5):580–5.
Buchman AS, Wilson RS, Bienias JL, Bennett DA. Change in frailty and risk of death in older persons. Exp Aging Res. 2009;35(1):61–82.
van Kempen JA, Schers HJ, Melis RJ, Olde Rikkert MG. Construct validity and reliability of a two-step tool for the identification of frail older people in primary care. J Clin Epidemiol. 2014;67(2):176–83.
van Kempen JA, Schers HJ, Jacobs A, et al. Development of an instrument for the identification of frail older people as a target population for integrated care. Br J Gen Pract. 2013;63(608):e225–31.
Rolfson DB, Majumdar SR, Tsuyuki R, et al. Validity and reliability of the Edmonton Frail Scale. Age Ageing. 2006;35(5):526–9.
Haley MN, Wells YD, Holland AE. Relationship between frailty and discharge outcomes in subacute care. Aust Health Rev. 2014;38(1):25–9.
Graham MM, Galbraith D, O’Neill D, et al. Frailty and outcome in elderly patients with acute coronary syndrome. Can J Cardiol. 2013;29:1610–5.
de Vries NM, Staal JB, Olde Rikkert MG, Nijhuis-van der Sanden MW. Evaluative frailty index for physical activity (EFIP): a reliable and valid instrument to measure changes in level of frailty. Phys Ther. 2013;93(4):551–61.
Jones DM, Song X, Rockwood K. Operationalizing a frailty index from a standardized comprehensive geriatric assessment. J Am Geriatr Soc. 2004;52(11):1929–33.
Jones D, Song X, Mitnitski A, Rockwood K. Evaluation of a frailty index based on a comprehensive geriatric assessment in a population based study of elderly Canadians. Aging Clin Exp Res. 2005;17(6):465–71.
Pilotto A, Rengo F, Marchionni N, et al. Comparing the prognostic accuracy for all-cause mortality of frailty instruments: a multicentre 1-year follow-up in hospitalized older patients. PLoS One. 2012;7(1):e29090. doi:10.1371/journal.pone.0029090.
Mitnitski AB, Graham JE, Mogilner AJ, Rockwood K. Frailty, fitness and late-life mortality in relation to chronological and biological age. BMC Geriatr. 2002;2:1. doi:10.1186/1471-2318-2-1.
Drubbel I, Bleijenberg N, Kranenburg G, et al. Identifying frailty: do the Frailty Index and Groningen Frailty Indicator cover different clinical perspectives? A cross-sectional study. BMC Fam Pract. 2013;14:64.
Drubbel I, de Wit NJ, Bleijenberg N, et al. Prediction of adverse health outcomes in older people using a frailty index based on routine primary care data. J Gerontol A Biol Sci Med Sci. 2013;68(3):301–8.
Tocchi C, Dixon J, Naylor M, et al. Development of a frailty measure for older adults: the frailty index for elders. J Nurs Meas. 2014;22(2):223–40.
Cesari M, Demougeot L, Boccalon H, et al. A self-reported screening tool for detecting community-dwelling older persons with frailty syndrome in the absence of mobility disability: the FiND questionnaire. PLoS One. 2014;9(7):e101745.
Doba N, Tokuda Y, Goldstein NE, et al. A pilot trial to predict frailty syndrome: the Japanese Health Research Volunteer Study. Exp Gerontol. 2012;47(8):638–43.
Bielderman A, van der Schans CP, van Lieshout MR, et al. Multidimensional structure of the Groningen Frailty Indicator in community-dwelling older people. BMC Geriatr. 2013;13:86.
Daniels R, van Rossum E, Beurskens A, et al. The predictive validity of three self-report screening instruments for identifying frail older people in the community. BMC Public Health. 2012;12:69.
Hoogendijk EO, van der Horst HE, Deeg DJ, et al. The identification of frail older adults in primary care: comparing the accuracy of five simple instruments. Age Ageing. 2013;42(2):262–5.
Metzelthin SF, Daniels R, van Rossum E, et al. The psychometric properties of three self-report screening instruments for identifying frail older people in the community. BMC Public Health. 2010;10:176.
Peters LL, Boter H, Buskens E, Slaets JPJ. Measurement properties of the groningen frailty indicator in home-dwelling and institutionalized elderly people. JAMDA. 2012;13:546–51.
Schuurmans H, Steverink N, Lindenberg S, et al. Old or frail: what tells us more? J Gerontol A Biol Sci Med Sci. 2004;59A(9):962–5.
Smets IH, Kempen GI, Janssen-Heijnen ML, et al. Four screening instruments for frailty in older patients with and without cancer: a diagnostic study. BMC Geriatr. 2014;14:26.
Steverink N, Slates JPJ, Schuurmans H, van Lis M. Measuring frailty: Developing and testing the GFI (Groningen Frailty indicatior). Gerontologist. 2001;41(1):236–7.
Tegels JJ, de Maat MF, Hulsewe KW, et al. Value of geriatric frailty and nutritional status assessment in predicting postoperative mortality in gastric cancer surgery. J Gastrointest Surg. 2014;18(3):439–45.
Guilley E, Ghisletta P, Armi F, et al. Dynamics of frailty and dependence in a five-year longitudinal study of octogenarians. Res Aging. 2008;30(3):299–317.
Chin A, Paw MJ, Dekker JM, Feskens EJ, et al. How to select a frail elderly population? A comparison of three working definitions. J Clin Epidemiol. 1999;52(11):1015–21.
Chin A, Paw MJ, de Groot LC, van Gend SV, et al. Inactivity and weight loss: effective criteria to identify frailty. J Nutr Health Aging. 2003;7(1):55–60.
Di Bari M, Profili F, Bandinelli S, et al. Screening for frailty in older adults using a postal questionnaire: rationale, methods, and instruments validation of the INTER-FRAIL study. J Am Geriatr Soc. 2014;62(10):1933–7.
Jung H-W, Kim S-W, Ahn S, et al. Prevalence and outcomes of frailty in Korean elderly population: comparisons of a multidimensional frailty index with two phenotype models. PLoS One. 2014;9(2):e87958. doi:10.1371/journal.pone.0087958.
Amici A, Baratta A, Linguanti A, et al. The Marigliano-Cacciafesta Polypathological Scale: A tool for assessing fragility. Arch Gerontol Geriatr. 2008;46(3):327–34.
Kim H, Higgins PA, Canaday DH, et al. Frailty assessment in the geriatric outpatient clinic. Geriatr Gerontol Int. 2014;14:78–83.
Kulminski AM, Ukraintseva SV, Kulminskaya IV, et al. Cumulative deficits better characterize susceptibility to death in elderly people than phenotypic frailty: lessons from the Cardiovascular Health Study. J Am Geriatr Soc. 2008;56(5):898–903.
Carriere I, Colvez A, Favier F, et al. Hierarchical components of physical frailty predicted incidence of dependency in a cohort of elderly women. J Clin Epidemiol. 2005;58(11):1180–7.
Pijpers E, Ferreira I, van de Laar RJ, et al. Predicting mortality of psychogeriatric patients: a simple prognostic frailty risk score. Postgrad Med J. 2009;85:464–9.
de Souto BP, Greig C, Ferrandez A-M. Detecting and categorizing frailty status in older adults using a self-report screening instrument. Arch Gerontol Geriatr. 2012;54:249–54.
Romero-Ortuno R, Walsh CD, Lawlor BA, Kenny RA. A frailty instrument for primary care: findings from the Survey of Health, Ageing and Retirement in Europe (SHARE). BMC Geriatr. 2010;10:57.
Romero Ortuno R. The Frailty Instrument for primary care of the Survey of Health, Ageing and Retirement in Europe (SHARE-FI): results of the Spanish sample. Rev Esp Geriatr Gerontol. 2011;46(5):243–9.
Romero-Ortuno R, O’Shea D, Kenny RA. The SHARE frailty instrument for primary care predicts incident disability in a European population-based sample. Qual Prim Care. 2011;19(5):301–9.
Romero-Ortuno R. The SHARE operationalized frailty phenotype: A comparison of two approaches. Eur Geriatr Med. 2013;4:255–9.
Romero-Ortuno R. The frailty instrument for primary care of the survey of health, ageing and retirement in Europe predicts mortality similarly to a frailty index based on comprehensive geriatric assessment. Geriatr Gerontol Int. 2013;13(2):497–504.
Romero-Ortuno R, Soraghan C. A Frailty Instrument for primary care for those aged 75 years or more: findings from the Survey of Health, Ageing and Retirement in Europe, a longitudinal population-based cohort study (SHARE-FI75+). BMJ Open. 2014;4:e006645. doi:10.1136/bmjopen-2014-006645.
Bilotta C, Nicolini P, Case A, et al. Frailty syndrome diagnosed according to the Study of Osteoporotic Fractures (SOF) criteria and adverse health outcomes among community-dwelling older outpatients in Italy. A one-year prospective cohort study. Arch Gerontol Geriatr. 2012;54(2):23–8.
Ensrud KE, Ewing SK, Taylor BC, et al. Comparison of 2 frailty indexes for prediction of falls, disability, fractures, and death in older women. Arch Intern Med. 2008;168(4):382–9.
Strawbridge WJ, Shema SJ, Balfour JL, et al. Antecedents of frailty over three decades in an older cohort. J Gerontol B Psychol Sci Soc Sci. 1998;53(1):9–16.
Matthews M, Lucas A, Boland R, et al. Use of a questionnaire to screen for frailty in the elderly: An exploratory study. Aging Clin Exp Res. 2004;16:34–40.
De Witte N, Gobbens R, De Donder L, et al. The comprehensive frailty assessment instrument: development, validity and reliability. Geriatr Nurs. 2013;34(4):274–81.
De Witte N, Gobbens R, De Donder L, et al. Validation of the comprehensive frailty assessment instrument against the tilburg frailty indicator. Eur Geriatr Med. 2013;4:248–54.
Garcia-Garcia FJ, Carcaillon L, Fernandez-Tresguerres J, et al. A new operational definition of frailty: the Frailty Trait Scale. J Am Med Dir Assoc. 2014;15(5):371.
Lopez D, Flicker L, Dobson A. Validation of the Frail Scale in a cohort of older Australian women. J Am Geriatr Soc Jan. 2012;60(1):171–3.
Andreasen J, Sørensen EE, Gobbens RJJ, et al. Danish version of the Tilburg Frailty Indicator--translation, cross-cultural adaption and validity pretest by cognitive interviewing. Arch Gerontol Geriatr. 2014;59(1):32–8.
Gobbens RJ, van Assen MA. The prediction of quality of life by physical, psychological and social components of frailty in community-dwelling older people. Qual Life Res. 2014;23(8):2289–300.
Gobbens RJJ, van Assen MA, Luijkx KG, et al. Determinants of Frailty. J Am Med Dir Assoc. 2010;10:356–64.
Gobbens RJ, van Assen MA, Luijkx KG, et al. The Tilburg Frailty Indicator: psychometric properties. J Am Med Dir Assoc. 2010;11(5):344–55.
Gobbens RJJ, van Assen MA, Luijkx KG, Schols JMGA. The predictive validity of the Tilburg Frailty Indicator: Disability, health care utilization, and quality of life in a population at risk. Gerontologist. 2012;52(5):619–31.
Gobbens RJJ, van Assen MALM. Frailty and its prediction of disability and health care utilization: The added value of interviews and physical measures following a self-report questionnaire. Arch Gerontol Geriatr. 2012;55(2):369–79.
Uchmanowicz I, Jankowska-Polańska B, Łoboz-Rudnicka M, et al. Cross-cultural adaptation and reliability testing of the Tilburg Frailty Indicator for optimizing care of Polish patients with frailty syndrome. Clin Interv Aging. 2014;9:997–1001.
Woods NF, LaCroix AZ, Gray SL, et al. Frailty: emergence and consequences in women aged 65 and older in the Women’s Health Initiative Observational Study. J Am Geriatr Soc. 2005;53:1321–30.
Chang S-F, Yang R-S, Lin T-C, et al. The Discrimination of Using the Short Physical Performance Battery to Screen Frailty for Community-Dwelling Elderly People. J Nurs Scholarsh. 2014;46(3):207–15.
Abellan van Kan G, Rolland YM, Morley JE, Vellas B. Frailty: toward a clinical definition. J Am Med Dir Assoc. 2008;9(2):71–2.
Peacock JL, Peacock PJ. Oxford Handbook of Medical Statistics. 1st ed. New York: Oxford University Press; 2011.
De Vet HCW, Trewee LB, Mokkink LB, Knol DL. Measurement in medicine a practical guide. New York: Cambridge University Press; 2011.
Hu LT, Bentler PM. Cut off criteria for fit indexes in covariance structure analysis: Conventional criteria versus new alternatives. Struct Equ Model: Multi J. 1999;6(1):1–55. doi:10.1080/10705519909540118.