Inouye SK, Westendorp RG, Saczynski JS. Delirium in elderly people. Lancet. 2014;383(9920):911–22.
Article
PubMed
Google Scholar
Young J, Murthy L, Westby M, Akunne A, O'Mahony R. Diagnosis, prevention, and management of delirium: summary of NICE guidance. BMJ. 2010;341:c3704.
Article
PubMed
Google Scholar
Witlox J, Eurelings LS, de Jonghe JF, Kalisvaart KJ, Eikelenboom P, van Gool WA. Delirium in elderly patients and the risk of postdischarge mortality, institutionalization, and dementia: a meta-analysis. JAMA. 2010;304(4):443–51.
Article
CAS
PubMed
Google Scholar
Krogseth M, Wyller TB, Engedal K, Juliebo V. Delirium is an important predictor of incident dementia among elderly hip fracture patients. Dement Geriatr Cogn Disord. 2011;31(1):63–70.
Article
PubMed
Google Scholar
Davis DH, Muniz TG, Keage H, Rahkonen T, Oinas M, Matthews FE, et al. Delirium is a strong risk factor for dementia in the oldest-old: a population-based cohort study. Brain. 2012;135(Pt 9):2809–16.
Article
PubMed
PubMed Central
Google Scholar
Fong TG, Jones RN, Shi P, Marcantonio ER, Yap L, Rudolph JL, et al. Delirium accelerates cognitive decline in Alzheimer disease. Neurology. 2009;72(18):1570–5.
Article
CAS
PubMed
PubMed Central
Google Scholar
Eeles EM, White SV, O'Mahony SM, Bayer AJ, Hubbard RE. The impact of frailty and delirium on mortality in older inpatients. Age Ageing. 2012;41(3):412–6.
Article
PubMed
Google Scholar
Siddiqi N, House AO, Holmes JD. Occurrence and outcome of delirium in medical in-patients: a systematic literature review. Age Ageing. 2006;35(4):350–64.
Article
PubMed
Google Scholar
Ryan DJ, O'Regan NA, Caoimh Ríô, Clare J, O'Connor M, Leonard M, et al. Delirium in an adult acute hospital population: predictors, prevalence and detection. BMJ Open. 2013; 3(1).
Korevaar JC, van Munster BC, de Rooij SE. Risk factors for delirium in acutely admitted elderly patients: a prospective cohort study. BMCGeriatr. 2005;5:6.
Google Scholar
Cole MG, Ciampi A, Belzile E, Dubuc-Sarrasin M: Subsyndromal delirium in older people: a systematic review of frequency, risk factors, course and outcomes. Int J Geriatr Psychiatry. 2012.
van Gool WA, van de Beek D, Eikelenboom P. Systemic infection and delirium: when cytokines and acetylcholine collide. Lancet. 2010;375(9716):773–5.
Article
PubMed
Google Scholar
Maclullich AM, Ferguson KJ, Miller T, de Rooij SE, Cunningham C. Unravelling the pathophysiology of delirium: a focus on the role of aberrant stress responses. JPsychosomRes. 2008;65(3):229–38.
Google Scholar
Cunningham C, Campion S, Lunnon K, Murray CL, Woods JF, Deacon RM, et al. Systemic inflammation induces acute behavioral and cognitive changes and accelerates neurodegenerative disease. BiolPsychiatry. 2009;65(4):304–12.
CAS
Google Scholar
Cerejeira J, Batista P, Nogueira V, Vaz-Serra A, Mukaetova-Ladinska EB. The stress response to surgery and postoperative delirium: evidence of hypothalamic-pituitary-adrenal axis hyperresponsiveness and decreased suppression of the GH/IGF-1 Axis. J Geriatr Psychiatry Neurol. 2013;26(3):185–94.
Article
PubMed
Google Scholar
Breitbart W, Marotta R, Platt MM, Weisman H, Derevenco M, Grau C, et al. A double-blind trial of haloperidol, chlorpromazine, and lorazepam in the treatment of delirium in hospitalized AIDS patients. Am J Psychiatry. 1996;153(2):231–7.
Article
CAS
PubMed
Google Scholar
Kalisvaart KJ, de Jonghe JF, Bogaards MJ, Vreeswijk R, Egberts TC, Burger BJ, et al. Haloperidol prophylaxis for elderly hip-surgery patients at risk for delirium: a randomized placebo-controlled study. J Am Geriatr Soc. 2005;53(10):1658–66.
Article
PubMed
Google Scholar
Skrobik YK, Bergeron N, Dumont M, Gottfried SB. Olanzapine vs haloperidol: treating delirium in a critical care setting. Intensive Care Med. 2004;30(3):444–9.
Article
PubMed
Google Scholar
Han CS, Kim YK. A double-blind trial of risperidone and haloperidol for the treatment of delirium. Psychosomatics. 2004;45(4):297–301.
Article
CAS
PubMed
Google Scholar
Tahir TA, Eeles E, Karapareddy V, Muthuvelu P, Chapple S, Phillips B, et al. A randomized controlled trial of quetiapine versus placebo in the treatment of delirium. J Psychosom Res. 2010;69(5):485–90.
Article
PubMed
Google Scholar
Lonergan E, Britton AM, Luxenberg J, Wyller T. Antipsychotics for delirium. Cochrane Batabase Syst Rev. 2007;2:CD005594.
Google Scholar
Grover S, Mattoo SK, Gupta N. Usefulness of atypical antipsychotics and choline esterase inhibitors in delirium: a review. Pharmacopsychiatry. 2011;44(2):43–54.
Article
CAS
PubMed
Google Scholar
Murray-Thomas T, Jones ME, Patel D, Brunner E, Shatapathy CC, Motsko S, et al. Risk of mortality (including sudden cardiac death) and major cardiovascular events in atypical and typical antipsychotic users: a study with the general practice research database. Cardio Vascular Psychiatry Neurol. 2013;2013:247486.
Google Scholar
Lonergan E, Luxenberg J, Areosa SA, Wyller TB. Benzodiazepines for delirium. Cochrane Database Syst Rev. 2009;1:CD006379.
PubMed
Google Scholar
van Eijk MM, Roes KC, Honing ML, Kuiper MA, Karakus A, van der Jagt M, et al. Effect of rivastigmine as an adjunct to usual care with haloperidol on duration of delirium and mortality in critically ill patients: a multicentre, double-blind, placebo-controlled randomised trial. Lancet. 2010;376(9755):1829–37.
Article
PubMed
Google Scholar
Overshott R, Karim S, Burns A. Cholinesterase inhibitors for delirium. Cochrane Database Syst Rev. 2008;1:CD005317.
PubMed
Google Scholar
Overshott R, Vernon M, Morris J, Burns A. Rivastigmine in the treatment of delirium in older people: a pilot study. Int Psychogeriatr. 2010;22(5):812–8.
Article
PubMed
Google Scholar
Khan ZP, Ferguson CN, Jones RM. alpha-2 and imidazoline receptor agonists. Their pharmacology and therapeutic role. Anaesthesia. 1999;54(2):146–65.
Article
CAS
PubMed
Google Scholar
Smith H, Elliott J. Alpha(2) receptors and agonists in pain management. Curr Opin Anaesthesiol. 2001;14(5):513–8.
Article
CAS
PubMed
Google Scholar
Uyar AS, Yagmurdur H, Fidan Y, Topkaya C, Basar H. Dexmedetomidine attenuates the hemodynamic and neuroendocrinal responses to skull-pin head-holder application during craniotomy. J Neurosurg Anesthesiol. 2008;20(3):174–9.
Article
PubMed
Google Scholar
Pichot C, Ghignone M, Quintin L. Dexmedetomidine and clonidine: from second- to first-line sedative agents in the critical care setting? J Intensive Care Med. 2012;27(4):219–37.
Article
CAS
PubMed
Google Scholar
Pandharipande PP, Pun BT, Herr DL, Maze M, Girard TD, Miller RR, et al. Effect of sedation with dexmedetomidine vs lorazepam on acute brain dysfunction in mechanically ventilated patients: the MENDS randomized controlled trial. JAMA. 2007;298(22):2644–53.
Article
CAS
PubMed
Google Scholar
Riker RR, Shehabi Y, Bokesch PM, Ceraso D, Wisemandle W, Koura F, et al. Dexmedetomidine vs midazolam for sedation of critically ill patients: a randomized trial. JAMA. 2009;301(5):489–99.
Article
CAS
PubMed
Google Scholar
Maldonado JR, Wysong A, van der Starre PJ, Block T, Miller C, Reitz BA. Dexmedetomidine and the reduction of postoperative delirium after cardiac surgery. Psychosomatics. 2009;50(3):206–17.
Article
CAS
PubMed
Google Scholar
Shehabi Y, Grant P, Wolfenden H, Hammond N, Bass F, Campbell M, et al. Prevalence of delirium with dexmedetomidine compared with morphine based therapy after cardiac surgery: a randomized controlled trial (DEXmedetomidine COmpared to Morphine-DEXCOM Study). Anesthesiology. 2009;111(5):1075–84.
Article
CAS
PubMed
Google Scholar
Mo Y, Zimmermann AE. Role of dexmedetomidine for the prevention and treatment of delirium in intensive care unit patients. Ann Pharmacother. 2013;47(6):869–76.
Article
PubMed
Google Scholar
Zhang H, Lu Y, Liu M, Zou Z, Wang L, Xu FY, et al. Strategies for prevention of postoperative delirium: a systematic review and meta-analysis of randomized trials. Crit Care. 2013;17(2):R47.
Article
PubMed
PubMed Central
Google Scholar
Bajwa S, Kulshrestha A. Dexmedetomidine: an adjuvant making large inroads into clinical practice. Ann Med Health Sci Res. 2013;3(4):475–83.
Article
PubMed
PubMed Central
Google Scholar
Cividjian A, Toader E, Wesseling KH, Karemaker JM, McAllen R, Quintin L. Effect of clonidine on cardiac baroreflex delay in humans and rats. Am J Physiol Regul Int Comp Physiol. 2011;300(4):R949–57.
Article
CAS
Google Scholar
Kim MH, Hahn TH. The effect of clonidine pretreatment on the perioperative proinflammatory cytokines, cortisol, and ACTH responses in patients undergoing total abdominal hysterectomy. Anesth Analg. 2000;90(6):1441–4.
Article
CAS
PubMed
Google Scholar
Blaudszun G, Lysakowski C, Elia N, Tramer MR. Effect of perioperative systemic alpha2 agonists on postoperative morphine consumption and pain intensity: systematic review and meta-analysis of randomized controlled trials. Anesthesiology. 2012;116(6):1312–22.
Article
CAS
PubMed
Google Scholar
Wright PM, Carabine UA, McClune S, Orr DA, Moore J. Preanaesthetic medication with clonidine. BrJ Anaesth. 1990;65(5):628–32.
Article
CAS
Google Scholar
Laurito CE, Baughman VL, Becker GL, DeSilva TW, Carranza CJ. The effectiveness of oral clonidine as a sedative/anxiolytic and as a drug to blunt the hemodynamic responses to laryngoscopy. J Clin Anesth. 1991;3(3):186–93.
Article
CAS
PubMed
Google Scholar
Rubino AS, Onorati F, Caroleo S, Galato E, Nucera S, Amantea B, et al. Impact of clonidine administration on delirium and related respiratory weaning after surgical correction of acute type-A aortic dissection: results of a pilot study. Interact CardiovascThorac Surg. 2010;10(1):58–62.
Article
Google Scholar
Anavekar SN, Jarrott B, Toscano M, Louis WJ. Pharmacokinetic and pharmacodynamic studies of oral clonidine in normotensive subjects. EurJ ClinPharmacol. 1982;23(1):1–5.
CAS
Google Scholar
Mohr E, Schlegel J, Fabbrini G, et al. CLonidine treatment of alzheimer's disease. Arch Neurol. 1989;46(4):376–8.
Article
CAS
PubMed
Google Scholar
Davidson M, Bierer LM, Kaminsky R, Ryan TM, Davis KL. Combined administration of physostigmine and clonidine to patients with dementia of the Alzheimer type: a pilot safety study. Alzheimer Dis Assoc Disord. 1989;3(4):224–7.
Article
CAS
PubMed
Google Scholar
Riekkinen M, Jakala P, Kejonen K, Riekkinen Jr P. The alpha2 agonist, clonidine, improves spatial working performance in Parkinson's disease. Neuroscience. 1999;92(3):983–9.
Article
CAS
PubMed
Google Scholar
Serrano-Duenas M. Treatment of sialorrhea in Parkinson's disease patients with clonidine. Double-blind, comparative study with placebo. Neurologia (Barcelona Spain. 2003;18(1):2–6.
CAS
Google Scholar
Almenrader N, Larsson P, Passariello M, Haiberger R, Pietropaoli P, Lonnqvist PA, et al. Absorption pharmacokinetics of clonidine nasal drops in children. Paediatr Anaesth. 2009;19(3):257–61.
Article
PubMed
Google Scholar
Hogan MJ, Wallin JD, Chu LC. Plasma clonidine concentration and pharmacologic effect. Clin Pharmacol Ther. 1981;30(6):729–34.
Article
CAS
PubMed
Google Scholar
Keranen A, Nykanen S, Taskinen J. Pharmacokinetics and side-effects of clonidine. Eur J Clin Pharmacol. 1978;13(2):97–101.
Article
CAS
PubMed
Google Scholar
Davies DS, Wing AM, Reid JL, Neill DM, Tippett P, Dollery CT. Pharmacokinetics and concentration-effect relationships of intervenous and oral clonidine. Clin Pharmacol Ther. 1977;21(5):593–601.
Article
CAS
PubMed
Google Scholar
Frisk-Holmberg M, Edlund PO, Paalzow L. Pharmacokinetics of clonidine and its relation to the hypotensive effect in patients. Br J Clin Pharmacol. 1978;6(3):227–32.
Article
CAS
PubMed
PubMed Central
Google Scholar
Sulheim D, Fagermoen E, Winger A, Andersen AM, Godang K, Muller F, et al. Disease mechanisms and clonidine treatment in adolescent chronic fatigue syndrome: a combined cross-sectional and randomized clinical trial. JAMA pediatrics. 2014;168(4):351–60.
Article
PubMed
Google Scholar
Fagermoen E, Sulheim D, Winger A, Andersen AM, Vethe NT, Saul JP, et al. Clonidine in the treatment of adolescent chronic fatigue syndrome: a pilot study for the NorCAPITAL trial. BMC Res Notes. 2012;5:418.
Article
CAS
PubMed
PubMed Central
Google Scholar
Anavekar SN, Howes LG, Jarrott B, Syrjanen M, Conway EL, Louis WJ. Pharmacokinetics and antihypertensive effects of low dose clonidine during chronic therapy. J Clin Pharmacol. 1989;29(4):321–6.
Article
CAS
PubMed
Google Scholar
Breitbart W, Rosenfeld B, Roth A, Smith MJ, Cohen K, Passik S. The memorial delirium assessment scale. J Pain Symptom Manag. 1997;13(3):128–37.
Article
CAS
Google Scholar
Association AP. Diagnostic and Statistical Manual of Mental Disorders: DSM-5. 5th ed. Washington DC: American Psychiatric Association; 2013.
Book
Google Scholar
Sands MB, Dantoc BP, Hartshorn A, Ryan CJ, Lujic S. Single question in delirium (SQiD): testing its efficacy against psychiatrist interview, the confusion assessment method and the memorial delirium assessment scale. Palliat Med. 2010;24(6):561–5.
Article
CAS
PubMed
Google Scholar
Sessler CN, Gosnell MS, Grap MJ, Brophy GM, O'Neal PV, Keane KA, et al. The Richmond Agitation-Sedation Scale: validity and reliability in adult intensive care unit patients. Am J Respir Crit Care Med. 2002;166(10):1338–44.
Article
PubMed
Google Scholar
Tieges Z, McGrath A, Hall RJ, Maclullich AM. Abnormal level of arousal as a predictor of delirium and inattention: an exploratory study. Am J Geriatric Psychiatry Off J Am Assoc Ger Psychiatry. 2013;21(12):1244–53.
Article
Google Scholar
Del App. http://www.edinburghdelirium.ed.ac.uk/.
Inouye SK, van Dyck CH, Alessi CA, Balkin S, Siegal AP, Horwitz RI. Clarifying confusion: the confusion assessment method. A new method for detection of delirium. AnnIntern Med. 1990;113(12):941–8.
CAS
Google Scholar
Holt R, Siddiqi N, Young J. The ethics of consent in delirium studies. J Psychosom Res. 2008;65(3):283–7.
Article
PubMed
Google Scholar
Adamis D, Treloar A, Martin FC, Macdonald AJ. Ethical research in delirium: arguments for including decisionally incapacitated subjects. Sci Eng Ethics. 2010;16(1):169–74.
Article
PubMed
Google Scholar
Wyller TB, Watne LO, Torbergsen A, Engedal K, Frihagen F, Juliebo V, et al. The effect of a pre- and post-operative orthogeriatric service on cognitive function in patients with hip fracture. The protocol of the Oslo Orthogeriatrics Trial. BMC Geriatr. 2012;12(1):36.
Article
PubMed
PubMed Central
Google Scholar
Andreasen NC, Pressler M, Nopoulos P, Miller D, Ho BC. Antipsychotic dose equivalents and dose-years: a standardized method for comparing exposure to different drugs. Biol Psychiatry. 2010;67(3):255–62.
Article
CAS
PubMed
Google Scholar
Mahoney FI, Barthel DW. Functional evaluation: the barthel index. Maryland State Med J. 1965;14:61–5.
CAS
Google Scholar
Lincoln NB, Gladman JR. The extended activities of daily living scale: a further validation. Disabil Rehabil. 1992;14(1):41–3.
Article
CAS
PubMed
Google Scholar
Jorm AF. A short form of the informant questionnaire on cognitive decline in the elderly (IQCODE): development and cross-validation. Psychol Med. 1994;24(1):145–53.
Article
CAS
PubMed
Google Scholar
Hughes CP, Berg L, Danziger WL, Coben LA, Martin RL. A new clinical scale for the staging of dementia. Br J Psychiatry J Mental Sci. 1982;140:566–72.
Article
CAS
Google Scholar
Folstein MF, Folstein SE, McHugh PR. "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975;12(3):189–98.
Article
CAS
PubMed
Google Scholar
Engedal K, Haugen P, Gilje K, Laake P. Efficacy of short mental tests in the detection of mental impairment in old age. Comp gerontol Section A Clin Lab Sci. 1988;2(2):87–93.
CAS
Google Scholar
Alexopoulos GS, Abrams RC, Young RC, Shamoian CA. Use of the Cornell scale in nondemented patients. J Am Geriatr Soc. 1988;36(3):230–6.
Article
CAS
PubMed
Google Scholar
Alexopoulos GS, Abrams RC, Young RC, Shamoian CA. Cornell scale for depression in dementia. Biol Psychiatry. 1988;23(3):271–84.
Article
CAS
PubMed
Google Scholar
Salvi F, Miller MD, Grilli A, Giorgi R, Towers AL, Morichi V, et al. A manual of guidelines to score the modified cumulative illness rating scale and its validation in acute hospitalized elderly patients. J Am Geriatr Soc. 2008;56(10):1926–31.
Article
PubMed
Google Scholar
Knaus WA, Draper EA, Wagner DP, Zimmerman JE. APACHE II: a severity of disease classification system. Crit Care Med. 1985;13(10):818–29.
Article
CAS
PubMed
Google Scholar
Feldt KS. The checklist of nonverbal pain indicators (CNPI). Pain Manage Nurs Off J Am Soc Pain Manage Nurs. 2000;1(1):13–21.
Article
CAS
Google Scholar
van Munster BC, Bisschop PH, Zwinderman AH, Korevaar JC, Endert E, Wiersinga WJ, et al. Cortisol, interleukins and S100B in delirium in the elderly. Brain Cogn. 2010;74(1):18–23.
Article
PubMed
Google Scholar
Khan BA, Farber MO, Campbell N, Perkins A, Prasad NK, Hui SL, et al. S100 calcium binding protein B as a biomarker of delirium duration in the intensive care unit - an exploratory analysis. Int J Gene Med. 2013;6:855–61.
Article
CAS
Google Scholar
Osse RJ, Fekkes D, Tulen JH, Wierdsma AI, Bogers AJ, van der Mast RC, et al. High preoperative plasma neopterin predicts delirium after cardiac surgery in older adults. J Am Geriatr Soc. 2012;60(4):661–8.
Article
PubMed
Google Scholar
Adamis D, Meagher D. Insulin-like growth factor I and the pathogenesis of delirium: a review of current evidence. J Aging Res. 2011;2011:951403.
Article
PubMed
PubMed Central
Google Scholar
Girard TD, Ware LB, Bernard GR, Pandharipande PP, Thompson JL, Shintani AK, et al. Associations of markers of inflammation and coagulation with delirium during critical illness. Intensive Care Med. 2012;38(12):1965–73.
Article
CAS
PubMed
PubMed Central
Google Scholar
Devlin JW, Al-Qadhee NS, Skrobik Y. Pharmacologic prevention and treatment of delirium in critically ill and non-critically ill hospitalised patients: A review of data from prospective, randomised studies. Best Pract Res Clin Anaesthesiol. 2012;26(3):289–309.
Article
CAS
PubMed
Google Scholar
Trzepacz PT, Bourne R, Zhang S. Designing clinical trials for the treatment of delirium. J Psychosom Res. 2008;65(3):299–307.
Article
PubMed
Google Scholar
Farewell D, Tahir TA, Bisson J. Statistical methods in randomised controlled trials for delirium. J Psychosom Res. 2012;73(3):197–204.
Article
PubMed
PubMed Central
Google Scholar
Adamis D. Statistical methods for analysing longitudinal data in delirium studies. Int Rev Psychiatry. 2009;21(1):74–85.
Article
PubMed
Google Scholar
Tahir TA, Farewell D, Bisson J. Randomised control trials for delirium: current evidence and statistical methods. J Psychosom Res. 2012;72(1):84–5.
Article
PubMed
Google Scholar