Table 1 Dosage plan for clonidine
Time | Safety | Dosage |
|---|---|---|
Day 1 | Systolic BP has to be >120 mmHg before the first loading dose. | 75 μg every 3rd hour until maximum 4 doses, (e.g.: at 2, 5, 8 and 11 p.m) |
Loading doses | If systolic BP is <100 mmHg, HR <50 beats/min, or if RASS is −3 or less before any of the subsequent loading doses, no more study medication will be given until the planned maintenance dose the next morning. | |
If RASS is −2, the treating physician has to assess if IMP will be given or not | ||
Day 2-7 | If systolic BP is <100 mmHg, HR <50 beats/min, or if RASS is −3 or less just before a planned dose, no study medication will be given until the next planned dose 12 hours later. | 75 μg BID, at 8–9 a.m and 8–9 p.m |
Maintenance doses | ||
If RASS is −2, the treating physician has to assess if IMP will be given or not |