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Frailty

Call for Papers:

With the number of older persons projected to double to 1.5 billion individuals by the year 2050, population aging has become a burgeoning global phenomenon. With frailty demanding further understanding of its epidemiological characteristics and course, advancements in frailty research are imperative for better understanding of how to diagnose, reduce and mediate the drastic impact frailty has on aging populations. Frailty is an increasingly important concept within both clinical practice and research, being linked to a more than 2 times increase in the risk of adverse outcomes such as mortality, hospitalization, functional disability, and falls.

Within this collection at BMC Geriatrics we are interested in attracting both clinical and experimental studies focused on, but not strictly limited to the following:

Epidemiology and Measurement

  • Early life risk factors of frailty
  • Characterization of trajectory of frailty development or transitions between frailty states and their implications in clinical care including end-of-life care
  • Covid19, other common infections and frailty
  • Neuropsychiatric diseases and frailty
  • Measurement of pre-frailty
  • Cognitive impairment, frailty, and their unique and/or intersecting pathophysiology
  • Frailty and other geriatric syndromes (e.g., Falls, cognitive impairment) and their unique and/or intersecting pathophysiology

Frailty biology

  • Novel biomarkers of pre-frailty and frailty, particularly related to cellular senescence, intercellular communication, and mitochondrial dysfunction
  • Characterization, quantification, and validation of multisystem dysregulations at the cellular, molecular, and/or physiological levels and their relationships with frailty
  • Life-course studies of frailty using animal models

Frailty and Clinical Care

  • Frailty in sub-specialties  (e.g., surgery, HIV, nephrology)
  • Frailty and comorbidity: distinguishing frailty and disease-specific pathology and its severity
  • Innovative community or clinical trials of interventions either targeting frailty and related biology or improving clinical care of pre-frail and frail older adults (including trial protocols)
  • Cost-benefit analysis of frailty interventions
  • Frailty and end-of-life care

Interdisciplinary topics

  • Frailty and technology (e.g., bioengineering, sensor technology)
  • Frailty and ethics

Systematic and scoping reviews and meta-analysis within each area listed above. 

Articles will undergo the journal’s standard peer-review process overseen by our Guest Editors:


Prof Ivan Aprahamian

Ivan Aprahamian is specialized in Internal Medicine, Geriatrics and Psychiatry. Currently, he is the director of the Geriatrics Program at the Jundiaí Medical School, Brazil and is also an Honorary Research Fellow at the Geriatric Psychiatry Department, University of Groningen. He holds a Fellowship position at the American College of Physicians and the International Society of Affective Disorders. His main research interests are frailty in the context of neuropsychiatric conditions including depressive disorders, cognitive impairment, sarcopenia and malnutrition in older adults. He also participated as co-author of 4 consensus of frailty.

Dr Qian-li Xue

Dr. Qian-Li Xue is Associate Professor of Medicine, Biostatistics, and Epidemiology at the Johns Hopkins University. He is a biostatistician and a gerontologist whose research focuses on the natural history of physical frailty with particular emphasis on measurement and research methods for understanding aging phenotypes including physical frailty and cognitive impairment. Dr. Xue is a fellow of the Gerontological Society of America.

Published articles

  1. The incorporation of acute frailty services into the acute care pathway is increasingly common. The prevalence and impact of acute frailty services in the UK are currently unclear.

    Authors: Thomas Knight, Catherine Atkin, Finbarr C Martin, Chris Subbe, Mark Holland, Tim Cooksley and Daniel Lasserson

    Citation: BMC Geriatrics 2022 22:19

    Content type: Research

    Published on:

  2. Healthcare systems need to adapt to better serve an aging population with complex presentations. Frailty assessments are a potential means to address this heterogeneity in aging to identify individuals at incr...

    Authors: Kevin F. Boreskie, Jacqueline L. Hay, Patrick E. Boreskie, Rakesh C. Arora and Todd A. Duhamel

    Citation: BMC Geriatrics 2022 22:13

    Content type: Review

    Published on:

  3. Multidimensional frailty, including physical, psychological, and social components, is associated to disability, lower quality of life, increased healthcare utilization, and mortality. In order to prevent or d...

    Authors: Marcel A. L. M. van Assen, Judith H. M. Helmink and Robbert J. J. Gobbens

    Citation: BMC Geriatrics 2022 22:7

    Content type: Research

    Published on:

  4. Routine screening for frailty at admission by nurses may be useful to detect geriatric risks and problems at an early stage. However, the added value of this screening is not clear yet. Information about the o...

    Authors: Ron M. J. Warnier, Erik van Rossum, Monique F. M. T. Du Moulin, Marjolein van Lottum, Jos M. G. A. Schols and Gertrudis I. J. M. Kempen

    Citation: BMC Geriatrics 2021 21:624

    Content type: Research

    Published on:

  5. Frailty is a kind of geriatric syndrome, which is very common in the elderly. Patients with malnutrition are at higher risk of frailty. This study explored the correlation between nutrition and frailty and com...

    Authors: Hong Liang, Xiaoping Li, Xiaoye Lin, Yanmin Ju and Jiyan Leng

    Citation: BMC Geriatrics 2021 21:619

    Content type: Research

    Published on:

  6. There is growing interest for interventions aiming at preventing frailty progression or even to reverse frailty in older people, yet it is still unclear which frailty instrument is most appropriate for measuri...

    Authors: Marlies Feenstra, Frederike M.M. Oud, Carolien J. Jansen, Nynke Smidt, Barbara C. van Munster and Sophia E. de Rooij

    Citation: BMC Geriatrics 2021 21:499

    Content type: Research article

    Published on:

  7. The association between sleep duration and frailty remains unconclusive since most of the studies have been cross-sectional. Therefore, this study aimed to analyze the association between sleep duration, sleep...

    Authors: Karla Moreno-Tamayo, Betty Manrique-Espinoza, Evangelina Morales-Carmona and Aarón Salinas-Rodríguez

    Citation: BMC Geriatrics 2021 21:368

    Content type: Research

    Published on:

  8. The Clinical Frailty Scale, which provides a common language about frailty, was recently updated to version 2.0 to cater for its increased use in areas of medicine usually involved in the care and treatment of...

    Authors: Anders Fournaise, Søren Kabell Nissen, Jørgen T. Lauridsen, Jesper Ryg, Christian H. Nickel, Claire Gudex, Mikkel Brabrand, Lone Musaeus Poulsen and Karen Andersen-Ranberg

    Citation: BMC Geriatrics 2021 21:269

    Content type: Correspondence

    Published on:

  9. Rehabilitation interventions are frequently cited as key in supporting frail older people’s recovery following periods of decompensation and acute ill-health. Clinicians are required to make decisions about a ...

    Authors: A. Cowley, S. E. Goldberg, A. L. Gordon, M. Kerr and P. Logan

    Citation: BMC Geriatrics 2021 21:165

    Content type: Research article

    Published on:

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