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Frailty

Call for Papers:

With the number of older persons projected to double to 1.5 billion individuals by the year 2050, population aging has become a burgeoning global phenomenon. With frailty demanding further understanding of its epidemiological characteristics and course, advancements in frailty research are imperative for better understanding of how to diagnose, reduce and mediate the drastic impact frailty has on aging populations. Frailty is an increasingly important concept within both clinical practice and research, being linked to a more than 2 times increase in the risk of adverse outcomes such as mortality, hospitalization, functional disability, and falls.

Within this collection at BMC Geriatrics we are interested in attracting both clinical and experimental studies focused on, but not strictly limited to the following:

Epidemiology and Measurement

  • Early life risk factors of frailty
  • Characterization of trajectory of frailty development or transitions between frailty states and their implications in clinical care including end-of-life care
  • Covid19, other common infections and frailty
  • Neuropsychiatric diseases and frailty
  • Measurement of pre-frailty
  • Cognitive impairment, frailty, and their unique and/or intersecting pathophysiology
  • Frailty and other geriatric syndromes (e.g., Falls, cognitive impairment) and their unique and/or intersecting pathophysiology

Frailty biology

  • Novel biomarkers of pre-frailty and frailty, particularly related to cellular senescence, intercellular communication, and mitochondrial dysfunction
  • Characterization, quantification, and validation of multisystem dysregulations at the cellular, molecular, and/or physiological levels and their relationships with frailty
  • Life-course studies of frailty using animal models

Frailty and Clinical Care

  • Frailty in sub-specialties  (e.g., surgery, HIV, nephrology)
  • Frailty and comorbidity: distinguishing frailty and disease-specific pathology and its severity
  • Innovative community or clinical trials of interventions either targeting frailty and related biology or improving clinical care of pre-frail and frail older adults (including trial protocols)
  • Cost-benefit analysis of frailty interventions
  • Frailty and end-of-life care

Interdisciplinary topics

  • Frailty and technology (e.g., bioengineering, sensor technology)
  • Frailty and ethics

Systematic and scoping reviews and meta-analysis within each area listed above. 

Articles will undergo the journal’s standard peer-review process overseen by our Guest Editors:


Prof Ivan Aprahamian

Ivan Aprahamian is specialized in Internal Medicine, Geriatrics and Psychiatry. Currently, he is the director of the Geriatrics Program at the Jundiaí Medical School, Brazil and is also an Honorary Research Fellow at the Geriatric Psychiatry Department, University of Groningen. He holds a Fellowship position at the American College of Physicians and the International Society of Affective Disorders. His main research interests are frailty in the context of neuropsychiatric conditions including depressive disorders, cognitive impairment, sarcopenia and malnutrition in older adults. He also participated as co-author of 4 consensus of frailty.

Dr Qian-li Xue

Dr. Qian-Li Xue is Associate Professor of Medicine, Biostatistics, and Epidemiology at the Johns Hopkins University. He is a biostatistician and a gerontologist whose research focuses on the natural history of physical frailty with particular emphasis on measurement and research methods for understanding aging phenotypes including physical frailty and cognitive impairment. Dr. Xue is a fellow of the Gerontological Society of America.

Published articles

  1. There are currently no validated globally and freely available tools to estimate the modified frailty index (mFI). The widely available and non-proprietary International Statistical Classification of Diseases ...

    Authors: Ashwin Subramaniam, Ryo Ueno, Ravindranath Tiruvoipati, Jai Darvall, Velandai Srikanth, Michael Bailey, David Pilcher and Rinaldo Bellomo
    Citation: BMC Geriatrics 2022 22:422
  2. To create an electronic frailty index (eFRAGICAP) using electronic health records (EHR) in Catalunya (Spain) and assess its predictive validity with a two-year follow-up of the outcomes: homecare need, institu...

    Authors: Francesc Orfila, Lucía A. Carrasco-Ribelles, Rosa Abellana, Albert Roso-Llorach, Francisco Cegri, Carlen Reyes and Concepción Violán
    Citation: BMC Geriatrics 2022 22:404
  3. Aneurysmal subarachnoid haemorrhage (aSAH) is a condition with significant morbidity and mortality. Traditional markers of aSAH have established their utility in the prediction of aSAH outcomes while frailty m...

    Authors: Jia Xu Lim, Yuan Guang Lim, Aravin Kumar, Tien Meng Cheong, Julian Xinguang Han, Min Wei Chen, David Wen, Winston Lim, Ivan Hua Bak Ng, Vincent Yew Poh Ng, Ramez Wadie Kirollos and Nicole Chwee Har Keong
    Citation: BMC Geriatrics 2022 22:333
  4. Cardiovascular disease (CVD) is associated with a greater frailty risk, but it remains unknown if pathways that contribute to CVD are associated with the frailty risk. Thus, we aimed to investigate whether ele...

    Authors: Yu Jia, Dongze Li, Jing Yu, Yi Liu, Fanghui Li, Wentao Li, Qin Zhang, Yongli Gao, Wei Zhang, Zhi Zeng, Rui Zeng, Xiaoyang Liao, Qian Zhao and Zhi Wan
    Citation: BMC Geriatrics 2022 22:321
  5. Low serum 25-hydroxyvitamin D [25(OH)D] level is associated with a greater risk of frailty, but the effects of daily vitamin D supplementation on frailty are uncertain. This secondary analysis aimed to examine...

    Authors: Yurun Cai, Amal A. Wanigatunga, Christine M. Mitchell, Jacek K. Urbanek, Edgar R. Miller III, Stephen P. Juraschek, Erin D. Michos, Rita R. Kalyani, David L. Roth, Lawrence J. Appel and Jennifer A. Schrack
    Citation: BMC Geriatrics 2022 22:312
  6. The process of aging renders older people susceptible for adverse outcomes upon stress. Various indicators derived from complex systems theory have been proposed for quantifying resilience in living organisms,...

    Authors: Alexandros Katsiferis, Pernille Yde Nielsen, Majken K. Jensen and Rudi G. J. Westendorp
    Citation: BMC Geriatrics 2022 22:301
  7. Despite increased recognition of frailty and its importance, high quality evidence to guide decision-making is lacking. There has been variation in reported data elements and outcomes which makes it challengin...

    Authors: Jeanette C. Prorok, Paula R. Williamson, Beverley Shea, Darryl Rolfson, Leocadio Rodriguez Mañas, Matteo Cesari, Perry Kim and John Muscedere
    Citation: BMC Geriatrics 2022 22:284
  8. Frailty is a complex multifactorial syndrome characterised by a significant increase in vulnerability and worsened health outcomes. Despite a range of proposed frailty screening measures, the prevalence and pr...

    Authors: Josh McGovern, Ross D. Dolan, Paul G. Horgan, Barry J. Laird and Donald C. McMillan
    Citation: BMC Geriatrics 2022 22:260
  9. Fear of falling (FoF) has far-reaching implications including activity restriction, functional decline and reduced quality of life. It is a common consequence of falls but may be present even in non-fallers. T...

    Authors: Jacqueline Giovanna De Roza, David Wei Liang Ng, Blessy Koottappal Mathew, Teena Jose, Ling Jia Goh, Chunyan Wang, Cindy Seok Chin Soh and Kar Cheng Goh
    Citation: BMC Geriatrics 2022 22:186
  10. To explore the association between social capital and frailty and the mediating effect of health-promoting lifestyles among Chinese older adults, while providing scientific evidence for frailty intervention.

    Authors: Shan Hu, Canhuan Jin and Shaojie Li
    Citation: BMC Geriatrics 2022 22:175
  11. Several methods are available for identifying frailty, but limited tools have been validated in Thai context. Our objective was to evaluate the validity and reliability of the Thai version of the Simple Frailt...

    Authors: Warut T.Sriwong, Waroonkarn Mahavisessin, Varalak Srinonprasert, Arunotai Siriussawakul, Wichai Aekplakorn, Panita Limpawattana, Patumporn Suraarunsumrit, Rachaneekorn Ramlee and Titima Wongviriyawong
    Citation: BMC Geriatrics 2022 22:161
  12. Healthcare outcome goals are central to person-centred acute care, however evidence among older people is scarce. Older people who are living with frailty have distinct requirements for healthcare delivery and...

    Authors: James David van Oppen, Timothy John Coats, Simon Paul Conroy, Jagruti Lalseta, Kay Phelps, Emma Regen, Peter Riley, Jose Maria Valderas and Nicola Mackintosh
    Citation: BMC Geriatrics 2022 22:156
  13. The prognostic value of frailty measures for post-stroke neurocognitive disorder (NCD) remains to be evaluated.

    Authors: Ragnhild Munthe-Kaas, Stina Aam, Ingvild Saltvedt, Torgeir Bruun Wyller, Sarah T. Pendlebury, Stian Lydersen, Guri Hagberg, Till Schellhorn, Siri Rostoft and Hege Ihle-Hansen
    Citation: BMC Geriatrics 2022 22:139
  14. Frailty predicts adverse post-kidney transplant (KT) outcomes, yet the impact of frailty assessment on center-level outcomes remains unclear. We sought to test whether transplant centers assessing frailty as p...

    Authors: Xiaomeng Chen, Yi Liu, Valerie Thompson, Nadia M. Chu, Elizabeth A. King, Jeremy D. Walston, Jon A. Kobashigawa, Darshana M. Dadhania, Dorry L. Segev and Mara A. McAdams-DeMarco
    Citation: BMC Geriatrics 2022 22:82
  15. The incorporation of acute frailty services into the acute care pathway is increasingly common. The prevalence and impact of acute frailty services in the UK are currently unclear.

    Authors: Thomas Knight, Catherine Atkin, Finbarr C Martin, Chris Subbe, Mark Holland, Tim Cooksley and Daniel Lasserson
    Citation: BMC Geriatrics 2022 22:19
  16. Healthcare systems need to adapt to better serve an aging population with complex presentations. Frailty assessments are a potential means to address this heterogeneity in aging to identify individuals at incr...

    Authors: Kevin F. Boreskie, Jacqueline L. Hay, Patrick E. Boreskie, Rakesh C. Arora and Todd A. Duhamel
    Citation: BMC Geriatrics 2022 22:13
  17. Multidimensional frailty, including physical, psychological, and social components, is associated to disability, lower quality of life, increased healthcare utilization, and mortality. In order to prevent or d...

    Authors: Marcel A. L. M. van Assen, Judith H. M. Helmink and Robbert J. J. Gobbens
    Citation: BMC Geriatrics 2022 22:7
  18. Routine screening for frailty at admission by nurses may be useful to detect geriatric risks and problems at an early stage. However, the added value of this screening is not clear yet. Information about the o...

    Authors: Ron M. J. Warnier, Erik van Rossum, Monique F. M. T. Du Moulin, Marjolein van Lottum, Jos M. G. A. Schols and Gertrudis I. J. M. Kempen
    Citation: BMC Geriatrics 2021 21:624
  19. Frailty is a kind of geriatric syndrome, which is very common in the elderly. Patients with malnutrition are at higher risk of frailty. This study explored the correlation between nutrition and frailty and com...

    Authors: Hong Liang, Xiaoping Li, Xiaoye Lin, Yanmin Ju and Jiyan Leng
    Citation: BMC Geriatrics 2021 21:619
  20. There is growing interest for interventions aiming at preventing frailty progression or even to reverse frailty in older people, yet it is still unclear which frailty instrument is most appropriate for measuri...

    Authors: Marlies Feenstra, Frederike M.M. Oud, Carolien J. Jansen, Nynke Smidt, Barbara C. van Munster and Sophia E. de Rooij
    Citation: BMC Geriatrics 2021 21:499
  21. The association between sleep duration and frailty remains unconclusive since most of the studies have been cross-sectional. Therefore, this study aimed to analyze the association between sleep duration, sleep...

    Authors: Karla Moreno-Tamayo, Betty Manrique-Espinoza, Evangelina Morales-Carmona and Aarón Salinas-Rodríguez
    Citation: BMC Geriatrics 2021 21:368
  22. The Clinical Frailty Scale, which provides a common language about frailty, was recently updated to version 2.0 to cater for its increased use in areas of medicine usually involved in the care and treatment of...

    Authors: Anders Fournaise, Søren Kabell Nissen, Jørgen T. Lauridsen, Jesper Ryg, Christian H. Nickel, Claire Gudex, Mikkel Brabrand, Lone Musaeus Poulsen and Karen Andersen-Ranberg
    Citation: BMC Geriatrics 2021 21:269
  23. Rehabilitation interventions are frequently cited as key in supporting frail older people’s recovery following periods of decompensation and acute ill-health. Clinicians are required to make decisions about a ...

    Authors: A. Cowley, S. E. Goldberg, A. L. Gordon, M. Kerr and P. Logan
    Citation: BMC Geriatrics 2021 21:165

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