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Association between elevated serum uric acid levels and high estimated glomerular filtration rate with reduced risk of low muscle strength in older people: a retrospective cohort study



We aimed to investigate the interaction between serum uric acid (SUA) levels with estimated glomerular filtration rate (eGFR) to low muscle strength (LMS) among older people in China.


Cohort data were obtained from China Health and Retirement Longitudinal Study (CHARLS) in 2011 and 2015. A total of 2,822 community-dwelling adults aged 60 and above were enrolled for the follow-up. Serum uric acid was collected after 8 h of fasting, and handgrip strength was measured with a dynamometer. eGFR was calculated with an equation based on the Chinese population. A generalized additive model was employed for interaction analysis and progressively adjusted confounders.


During the follow-up, a total of 659 individuals were excluded due to the lack of grip strength data, leaving 2,163 participants for analysis. Despite the protective effect of high uric acid against low muscle strength, especially in older females, it is not statistically significant (OR = 0.69, 95%CI = 0.45–1.04, P = 0.075). Following the progressive adjustment of covariates, the association between higher eGFR and elevated SUA levels remained statistically significant in females, showing a reduced odds ratio with low muscle strength (OR = 0.82, 95%CI = 0.70–0.97, P = 0.021). However, this trend was not observed in male participants.


This Chinese population-based cohort study suggests that among older females, a higher serum uric acid level combined with a higher estimated glomerular filtration rate is linked to a reduced risk of low muscle strength. This implies that the relationship between high serum uric acid levels and the risk of low grip strength might differ by gender.

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With advancing age, the human body is accompanied by a series of physiological changes, including the loss of skeletal muscle mass and strength, which is defined as sarcopenia [1]. Muscle strength, especially handgrip strength, is a crucial parameter for assessing and diagnosing sarcopenia [2]. The declined strength as a predicted factor is also associated with an increased risk of falls [3], fracture [4], cancer [5], and even mortality [6, 7]. Despite many factors affecting the loss of muscle strength in older people, the accumulation of reactive oxygen species (ROS) is one of the reasons for the age-related functional losses [8], causing oxidative protein damage and diminishing muscular strength [9].

Serum uric acid (SUA) is an end-product of purine metabolism and is believed to possess both pro-oxidant and antioxidant properties [10]. Furthermore, SUA has been proposed as a dependable indicator of oxidative stress [11]. However, the existing body of research on the association between SUA levels and low muscle strength (LMS) has produced inconsistent outcomes. Some studies have suggested the existence of an optimal range of SUA levels that correlates with improved grip strength [12, 13]. In contrast, a cross-sectional study utilizing data from the WCHAT (West China Health and Aging Trend) suggested a positive association between SUA levels and muscle strength [14]. Similarly, a NHANES (National Health and Nutrition Examination Survey) study also supported the notion that higher SUA levels could serve as a protective factor for muscle strength in older people [15].

Conversely, findings from the PRO.V.A. (Progetto Veneto Anziani) cohort study demonstrated that hyperuricemia was associated with reduced physical performance in older people, particularly concerning handgrip strength among men [16]. These conflicting results underscore the need for further comprehensive investigation and analysis to elucidate the potential role of SUA in contributing to age-related decline in muscle strength. As such, it remains unclear whether the causal relationship between high uric acid levels and increased grip strength, especially since most existing literature is based on cross-sectional studies that cannot determine causality.

Moreover, the relationship between SUA and muscle strength is intricately linked to kidney function. Approximately 70% of uric acid excretion is regulated through renal mechanisms. Thus, considering the different stages of kidney function related to SUA levels is crucial when studying the association with muscle strength. It has been observed that muscle strength tends to decrease significantly in individuals with lower estimated glomerular filtration rate (eGFR) [17], suggesting a potential interplay between SUA levels and kidney function in their influence on muscle strength.

Therefore, this study aimed to use data from the CHARLS (China Health and Retirement Longitudinal Study) to investigate the relationship between UA and low muscle strength and to explore the relationship between high eGFR level with SUA levels to low muscle strength in older people in China.


Study population

The CHARLS survey recruited from 150 counties or districts and 450 villages in 28 provinces in China, generally representing China’s older people annual population. In short, the CHARLS is a nationally representative longitudinal survey focusing on individuals over age 45 residing in diverse communities across China. Initially, our study included 17,708 participants aged over 45 who were enrolled in 2011 at the baseline. However, after excluding 14,886 participants, we were left with 2,822 individuals eligible for follow-up. Participants were excluded based on certain criteria, including incomplete demographic data (N = 59), age under 60 (N = 9,985), incomplete biochemical parameters (N = 3,336), missing lifestyle survey data (N = 16), and absence of anthropometric parameters (N = 613), and low grip strength (N = 877). Additionally, in 2015, 659 participants were excluded due to missing handgrip strength data. As a result, the final analysis comprised 2,163 participants, as shown in Fig. 1. All participants underwent an assessment using a standardized questionnaire interviewed by well-trained staff to collect data on demographic, lifestyle, and health-related information. Detailed information on CHARLS has been published previously [18]. All participants provided informed consent; the Ethical Review Committee of Peking University approved the study protocol (IRB00001052–11,015).

Fig. 1
figure 1

Flow chart of the study participants

Measurement of SUA and eGFR

Venous blood samples were collected from each participant after 8 h of fasting in wave 2011. SUA levels (mg/dL) were analyzed using enzymatic-colorimetric methods. The detection limits were up to 20 mg/dL, and the coefficient of variation (CV) intra-assay and inter-assay was equal to 1.10% and 1.90%, respectively. The estimated glomerular filtration rate (eGFR) was calculated based on the result of a multicenter study in Chinese populations [19]. The equation is eGFR = 173.9×CysC− 0.725×Cr− 0.184×Age− 0.193 × 0.89 [if female]. An eGFR ≥ 60 (mL/min/1.73 m2) is defined as a high eGFR level, and vice versa.

Assessment of muscle strength

Muscle strength was evaluated through handgrip strength, measured in kilograms (kg) using a dynamometer (YuejianTM WL-1000, Nantong, China). Participants performed the test while sitting or standing, holding the dynamometer with one hand at a 90° elbow flexion, and exerted maximum force for a brief period. The best measurement from either the right or left hand was recorded as the handgrip strength. According to a recent study concerning low muscle strength in older Chinese adults, the established cutoff points were 28.5 kg for men and 18.6 kg for women [20].

Study variables

The present study variables included demographic information, anthropometric parameters, and blood sample. Demographic information was collected by trained staff during face-to-face interviews, including age, gender, education, smoking habits, alcohol consumption, and medical history of self-reported diagnosis. Smoking habits indicated whether the respondent reports ever smoking. Drinking consumption was defined whether the participants have had any alcoholic beverage in the past 12 months. Medical history encompasses the respondents’ self-reported answers to whether a doctor has previously diagnosed them with a specific medical condition, including hypertension, diabetes, dyslipidemia, cancer, liver disease, and kidney disease. Other biomarkers, including anthropometric parameters and blood, were collected by China CDC staff. Body mass index (BMI) was calculated as weight(kg) divided by the square of height (m2). Waist circumferences (cm) were measured using soft tape around the navel. As mentioned above, blood samples were collected after 8 h of fasting. These biochemical parameters included high-sensitivity CRP (hs-CRP), glycosylated hemoglobin (HbA1c), total cholesterol (TC), triglycerides (TG), HDL cholesterol (HDL-c), LDL cholesterol (LDL-c), creatinine (Cr), and cystatin C (Cys C).

Statistical analysis

The continuous variables were expressed as mean ± standard deviations (SDs) for normal distribution, and the categorical variables were addressed as frequency and proportion. Those covariates with skewed distribution were presented as median (P25, P75), including hs-CRP and TG. For categorical variables, the potential differences among groups were employed by one-way analysis of variance (ANOVA)(normal distribution) or KruskalWallis rank sum test (skewed distribution). For the categorical variables, we employed the chi-squared test to identify any significant differences across various groups. The association between serum uric acid (UA) and low muscle strength (LMS) was assessed by calculating odds ratios (ORs) and corresponding 95% confidence intervals (CIs) using multivariate logistic regression models. A generalized additive model was employed for interaction analysis and calculated the odds ratio (OR) and 95% confidence interval (CI) for the relationship between SUA per-SD (mg/dL) increased and LMS by different eGFR. We progressively adjusted for age, education levels, smoking habits, drinking consumption, BMI, waist circumferences, medical history (hypertension, diabetes, dyslipidemia, cancer, liver disease, and kidney disease), lipid profiles (TC, TG, HDL-c, and LDL-c), hemoglobin, HbA1c, and hs-CRP. After adjusting for the abovementioned factors, the smoothing plots were illustrated to explore the possible non-linear association between SUA and LMS stratified by eGFR levels.

We conducted a sensitivity analysis using the VIF (variance inflation factor) method to assess the potential impact of multicollinearity between glycated hemoglobin and diabetes, as well as between serum lipids and dyslipidemia.

𝑃 < 0.05 was considered statistically significant. All the statistical analyses were performed using EmpowerStats (; X&Y Solutions, Inc., Boston, MA, USA) and the R package (4.2.0 version).


The participants were divided into groups based on the quartiles of UA levels separately for males and females, as shown in Table 1. Overall, the average blood uric acid levels are higher in males compared to females (5.02 (mg/dL) ± 1.29 in male vs. 4.16 (mg/dL) ± 1.12 in female, P < 0.001). Women have higher eGFR levels than men (74.91 (mL/min/1.73 m2) ± 13.70 in male vs. 83.57 (mL/min/1.73 m2) ± 16.33 in female, P < 0.001). Both genders experience a decrease in estimated glomerular filtration rate (eGFR) as blood uric acid levels increase. Females tend to have a higher proportion of non-smokers and non-drinkers in comparison to males. Moreover, in females, there is an observed increase in grip strength as blood uric acid levels rise.

Table 1 Baseline characteristics of participants according to the quartiles of uric acid and gender

Table 2 presented the association between UA quartiles and low grip strength by genders. In comparison to males, the protective effect of high uric acid levels against low grip strength was only observed in older females, although there may not be a statistically significant difference possibly due to the sample size (OR = 0.69, 95%CI = 0.45–1.04, P = 0.075).

Table 2 The association between UA quartiles and Low grip strength in non-adjusted model and full-adjusted model by genders after excluding low grip strength at baseline

Table 3 presented the stratification of eGFR into high and low groups to explore its interaction with SUA concerning low grip strength. In females, the association between a high eGFR level and serum uric acid remained significant in the low grip strength, after progressively adjusting for several risk factors (OR = 0.82, 95%CI = 0.70–0.97, P = 0.021). In contrast, such a relationship was not observed in men (OR = 1.08, 95%CI = 0.94–1.25, P = 0.2714). Additionally, we detected a statistically significant interaction between different eGFR levels in women (P = 0.034) in contrast to the interaction analysis in men (P = 0.445).

Table 3 Association of SUA perSD increases with the risk of low muscle strength in different eGFR levels by genders

Figure 2 demonstrated the association between SUA levels and the risk of LMS through a smoothing plot. This analysis incorporated adjustments for the aforementioned risk factors and involves stratification based on different eGFR levels. The findings unveiled a significant trend among female subjects, wherein an elevated uric acid concentration exhibited a protective effect against the occurrence of low muscle strength, but only in conjunction with a higher estimated glomerular filtration rate. However, this trend was not observed in male participants.

The sensitivity analysis indicated that there was multicollinearity in TC and LDL, as shown in Table S1. However, compared to the original model, removing TC did not affect the association between serum uric acid and grip strength, regardless of gender, as shown in Table S2.

Fig. 2
figure 2

The association between serum uric acid and the risk of low muscle strength stratification by different eGFR levels in the smoothing plot with full adjustment in male (A) and female (B)


To the best of our knowledge, this was the first cohort study that investigated the causal relationship between serum uric acid and the risk of low muscle strength at different eGFR levels above 60 years population. Our results suggested that high uric acid levels only provide a protective effect against low muscle strength when accompanied by high eGFR levels, especially in older females.

These results help to clarify conflicts among previous studies. Some cross-sectional studies reported a positive association between higher uric acid levels and better grip strength [14, 21]. However, these studies did not account for the influence of eGFR or adjust for eGFR as a confounding factor, potentially leading to misleading conclusions regarding the effect of uric acid on muscle strength. In contrast, our study at baseline excluded individuals who already had low muscle strength to minimize the impact of this population, ensuring a causal relationship between uric acid and muscle strength. Our study is in line with the findings of a Korean study that excluded populations with eGFR < 60 and demonstrated a positive association between SUA and grip strength in older people [22]. Moreover, Nahas et al. also adjusted for eGFR and other confounders, showing that older men and women may benefit from higher SUA levels for better handgrip strength [15]. Thus, our study, along with the abovementioned studies, suggests that a high eGFR level may act as a protective factor, allowing serum uric acid levels to positively impact muscular strength.

We have observed that different eGFR levels can lead to contrasting effects of SUA on the risk of LMS in both men and women. However, the underlying mechanism by which a high serum level of SUA is associated with a decreased risk of LMS in varying eGFR conditions remains uncertain. Many studies have proposed that SUA may exhibit antioxidant properties by scavenging reactive oxygen species (ROS), thereby reducing oxidative stress [12,13,14,15,16, 21, 22]. Nevertheless, this hypothesis may require further exploration, especially concerning lower eGFR levels. The accumulation of SUA due to declining kidney function may be influenced by alterations in the body’s chemical environment, potentially affecting the antioxidant ability of uric acid [23]. For instance, the accumulation of bicarbonate, often seen in renal insufficiency-related electrolyte disturbances, might compromise uric acid’s capacity to counteract tyrosine nitrosylation, a crucial mechanism of oxidative damage [24].

Furthermore, recent research suggested that uric acid may contribute to oxidative stress rather than acting as an antioxidant under physiological conditions [11]. It has been established that uric acid can directly contribute to the production of ROS, and the antioxidant properties of uric acid may be offset by ROS generated from xanthine oxidoreductase-catalyzed reactions. This suggests that only the administration of exogenous uric acid might exhibit an antioxidative stress effect. For example, studies have demonstrated improved clinical outcomes in patients with acute ischemic stroke following uric acid administration [25], and in mice with Parkinson’s disease, uric acid injections have shown a neuroprotective effect [26]. Consequently, the accumulation of oxidative stress may play a role in the reduction of age-related declines in muscle strength [27] and kidney function [8]. However, since accurate detection of circulating xanthine oxidoreductase activity is not yet prevalent in clinical settings and there are limited studies exploring exogenous uric acid’s impact on muscle strength improvement, further investigation is required to determine whether uric acid acts as an antioxidant in muscle wasting associated with aging.

Our findings also revealed that the impact of SUA on LMS in different eGFR levels is sex specific. Specifically, women with high eGFR levels and higher serum uric acid showed a 18% lower risk of LMS, which contrasts with the results of a previous study. Veronese et al. conducted a cohort study and adjusted for eGFR and other confounders, reporting that hyperuricemia in men was associated with lower handgrip strength, while this relationship was not observed in women [16]. Gender differences play a critical role in the associations between physical activity and muscle strength during aging [28]. The consensus of Asian working group for sarcopenia 2019 revealed that sarcopenia was more prevalent in men than women, suggesting that sexual dimorphism may influence the disease’s pathogenesis [2].

Sex hormones may contribute to the differences between genders, affecting circulating uric acid levels, eGFR, and muscle strength. During adolescence, higher testosterone and lower sex hormone-binding globulin have been reported as gender differences in circulating uric acid [29]. With aging, testosterone levels decrease, impacting body composition, including reduced muscle mass, decreased strength, and increased muscular fatigue [30]. High follicle-stimulating hormone has been linked to declined eGFR in post-menopausal women [31]. A mendelian randomization study from the United Kingdom Biobank population suggested that high sex hormone-binding globulin was associated with better kidney function and a lower risk of chronic kidney disease (CKD) in men [32]. A prospective cohort study by Tsai et al., using data from the MJ Health Screening Database, indicated that a low serum testosterone level (< 400 ng/dL) was significantly associated with a high SUA level (> 7 mg/dL) in males [33]. Furthermore, testosterone therapy could pharmacologically increase serum uric acid [34], possibly through elevated UA production by simulating xanthine oxidase [35]. Testosterone administration has also been shown to increase muscle mass [36], muscle strength, and muscle power [37]. These studies collectively suggest that testosterone may contribute to a gender-specific difference in the relationship between SUA and LMS. Therefore, the interaction of sex differences in muscular strength and circulating uric acid in kidney function warrants further attention and investigation.

Despite the theory of sex hormones and oxidative stress, other possibilities could be affecting muscular strength with SUA level. First, sarcopenia has been linked to chronic low-grade inflammation [38], and high SUA levels resulting from decreased renal excretion might lead to the formation of urate crystals [39], potentially inducing conditions like gout and nephrolithiasis. These conditions can lead to an increase in circulating inflammatory mediators. A meta-analysis has shown that higher circulating inflammatory markers, such as CRP and IL-6, were associated with a decline in muscular strength [40]. However, in the present study, after adjusting for hs-CRP, the results remained consistent, suggesting that inflammation may not be the primary driver of muscle strength loss in this context. This finding is in line with a Danish cohort study that also showed a weak relationship between high hs-CRP levels and low muscular mass [41]. Second, metabolic syndrome has been associated with lower muscular strength [27], and high waist circumference has been positively correlated with reduced handgrip strength [42]. Nevertheless, in our study, the results remained robust even after adjusting for various metabolic factors, including BMI, waist circumference, lipid profiles, HbA1c, and medical history separately. This indicates that metabolic syndrome may not be the crucial factor influencing the relationship between SUA and LMS in different eGFR levels. Third, decreased hemoglobin levels have been associated with sarcopenia in non-dialysis chronic kidney disease patients [43] and kidney transplant recipients [44]. In the present study, adjusting for hemoglobin levels did not alter the results in women and men.


Although our hypotheses were supported statistically, our study’s results should be interpreted within its limitations. First, we did not evaluate whether the SUA levels changed during the follow-up and investigated the potential confounders of SUA levels at the baseline, including allopurinol and diuretics. Second, despite adjusting significant covariates separately, we cannot exclude the residual confounding of unmeasured factors in an observational study, including sex hormones, biomarkers of oxidative stress, nutritional status, and daily activity. Third, we did not have any information about gout history in this cohort. Moreover, the results should not be extrapolated to the presence of gout, which was related to SUA level and may affect the performance of muscle strength testing. Fourth, we focused on the population above 60yrs, which means that the results should not be extrapolated to those under 60 years, as they were “healthier” than older people.


The population-based cohort study conducted in Chinese older adults has shed light on the association between high SUA levels and muscle strength. This study emphasized the importance of considering sex-specific differences in these associations and suggest that high SUA levels, in conjunction with high eGFR, may have a protective effect on muscle strength in older women. Further research is warranted to explore the underlying mechanisms that drive these associations and to confirm the potential benefits of maintaining appropriate SUA levels in older people, especially females, to support muscle health.

Data Availability

The datasets generated and analyzed during the current study are available in the CHARLS database, which is publicly available on the CHARLS website (



Serum uric acid


estimated glomerular filtration rate


Low muscle strength


Body mass index


China Health and Retirement Longitudinal Study ORs:odds ratio


confidence interval


coefficient of variation


high-sensitivity CRP


glycosylated hemoglobin


total cholesterol




HDL cholesterol


LDL cholesterol



Cys C:

cystatin C


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This work is based on China Health and Retirement Longitudinal Study [CHARLS]. We especially thank the institute of social science survey and the national school of development of Peking University for providing data. We also gratefully acknowledge the suggestions from Jian Pang in manuscript revision.


This work was supported by the Shanghai Municipal Administrator of Traditional Chinese Medicine [ZY (2021–2023)-0209-02]; Shanghai Municipal Clinical Research Center for Chronic Musculoskeletal Conditions (no. 20MC1920600); Shanghai High-Level Local University Innovation Team (SZY20220315); Shanghai clinical specialty traditional Chinese medicine orthopedic traumatology (shslczdzk03901).

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YCH was responsible for the study conception and design, data acquisition, statistical analysis, and manuscript writing. SLC was responsible for acquiring data and writing and revising the manuscript. YD was responsible for statistical analysis and interpretation of data. YS was responsible for the study conception and design, data interpretation, and manuscript revision. All authors read and approved the final manuscript.

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Correspondence to Ying Shi.

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The study was approved by the ethics committee of Peking University (IRB00001052–11015).

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Huang, Y.C., Chen, S.L., Dong, Y. et al. Association between elevated serum uric acid levels and high estimated glomerular filtration rate with reduced risk of low muscle strength in older people: a retrospective cohort study. BMC Geriatr 23, 652 (2023).

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