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Table 4 Results on the association between frailty and the hospitalization-related outcomes, both at the cross-sectional level and at-follow up

From: Healthcare cost expenditures associated to frailty and sarcopenia

 

Cross-sectional analysis

At follow-up

Frailty measured with the Frailty Index

Frailty measured with the FTS5

Frailty measured with the Frailty Index

Frailty measured with the FTS5

Model 1

 OR on the probability of being admitted to hospital

3.611*** (2.666–4.899)

1.586* (1.045–2.361)

2.687*** (1.990–3.609)

2.127*** (1.505–3.110)

 Coeff on number of hospital admissions

0.366 (− 0.092–0.824)

0.397 (− 0.247–1.039)

0.535*** (0.306–0.764)

0.327* (0.104–0.757)

 Coeff on length of hospitalization

0.739*** (0.417–1.061)

0.526* (0.094–0.959)

0.626*** (0.349–0.902)

0.183* (0.062–0.360)

 Coeff on hospitalization costs

0.104 (− 0.121–0.330)

0.206* (0.075–0.487)

0.212* (0.040–0.385)

0.064 (− 0.239–0.367)

Model 2

 OR on the probability of being admitted to hospital

2.797*** (2.000–3.923)

1.283* (1.003–1.996)

2.337*** (1.677–3.221)

2.086*** (1.420–3.181)

 Coeff on number of hospital admissions

0.558 (− 0.081–1.196)

0.515 (− 0.178–1.209)

0.628*** (0.342–0.914)

0.397* (0.084–0.877)

 Coeff on length of hospitalization

0.845** (0.349–1.344)

0.498* (0.039–0.958)

0.724** (0.303–1.145)

0.155 (− 0.241–0.551)

 Coeff on hospitalization costs

0.168 (− 0.062–0.398)

0.112* (0.039–0.185)

0.327** (0.142–0.512)

0.131* (0.013–0.249)

Model 3

 OR on the probability of being admitted to hospital

2.172** (1.296–3.666)

1.054 (0.643–1.697)

1.766* (1.065–2.876)

1.701* (1.102–2.716)

 Coeff on number of hospital admissions

0.127 (− 0.717–0.972)

0.301 (− 0.470–1.073)

0.616** (0.189–1.043)

0.518* (0.069–0.966)

 Coeff on length of hospitalization

0.719** (0.183–1.256)

0.555* (0.068–1.042)

0.761** (0.291–1.231)

0.274 (− 0.202–0.750)

 Coeff on hospitalization costs

0.179 (− 0.214–0.572)

0.186 (− 0.143–0.229)

0.278* (0.003–0.553)

0.201* (0.115–0.287)

Model 4

 OR on the probability of being admitted to hospital

1.801* (1.070–3.046)

0.937 (0.569–1.523)

1.445 (0.870–2.360)

1.481* (1.014–2.403)

 Coeff on number of hospital admissions

− 0.101 (− 0.819–0.617)

0.183 (− 0.516–0.882)

0.509* (0.075–0.944)

0.473* (0.066–0.881)

 Coeff on length of hospitalization

0.450 (− 0.016–0.916)

0.357 (− 0.075–0.789)

0.611** (0.200–1.023)

0.220 (− 0.210–0.650)

 Coeff on hospitalization costs

0.008 (− 0.342–0.359)

0.212 (− 0.113–0.538)

0.227 (− 0.060–0.514)

0.181* (0.012–0.350)

  1. 95% confidence intervals in parentheses. *** p < 0.001, ** p < 0.01, * p < 0.05
  2. Model 1 includes frailty status, measured by the Frailty Index or the Frailty Trait Score, as the only independent variable. Model 2 enters sociodemographic characteristics (age and its square and gender) in addition to frailty. Model 3 adds to Model 2 sarcopenia. Models 4 adds the comorbidity severity of individual according to the Charlson Index, which is medium-low if the Charlson Index score is 1 or 2; and high if the Charlson Index score is three or higher. Moreover, polypharmacy is also included if the daily number of drugs the subject is taking is 5 or more