A longitudinal magnetic resonance imaging study of neurodegenerative and small vessel disease, and clinical cognitive trajectories in non demented patients with transient ischemic attack: the PREVENT study

Table 2 PREVENT imaging comprehensive dementia protocol < 20 min of scan time

Imaging Sequence	Mechanistic Target	Endpoint	Geometric Parameters (2D/3D, FOV)	Acquisition Parameters (TE/TR/flip)
3-plane localizer			2D, 24 cm, 8 mm/ 8 mm, 33, 256 × 128	1.3 ms/ 4.8 ms/ 30°
High Resolution T1-weighted	Atrophy	Primary and secondary outcome	3D, 24 cm² 2.0 mm/ 0 mm, 70, 256 × 256	3 ms/ 7 ms/ 8° (minTE, minTR)
3D T2-weighted FLAIR	WML volume	Predictor of primary outcome	3D, 24 cm, 1 mm/ 0 mm, 38, 256 × 256	140 ms/ 9000 ms/ 90°
Axial 3D QSM	Neurodegeneration Brain iron content	Predictor of primary outcome	3D, 24 cm, 2 mm/0 mm, 192 × 192	29.5 ms/3 ms/8°
3D Proton Density	WML volume		3D SPGR, 1 mm/ 0 mm, 256 × 256
Diffusion tensor DWI	Microstructure Acute cytotoxic ischemia		2D, 24 cm, 3.5 mm/ 0 mm, 38, 144 × 144 matrix	70 ms - 80 ms/ 13,000 ms/ 90°
Axial T2 star	Microhemorrhage		2D, 24 cm, 3.5 mm/ 0 mm, 38, 256 × 224	140 ms/ 9000 ms/ 90°7

ISSN: 1471-2318