Optimal treatment strategy in extremely elderly patients with hepatocellular carcinoma
© Ruzzenente et al; licensee BioMed Central Ltd. 2009
Published: 1 April 2009
Background and objective
The hepatocellular carcinoma (HCC) is a frequent cancer worldwide. This disease is more frequent in patients over 70 years and only few papers in literature analyze the clinical characteristics and the survival of elderly patients with HCC. The aim of this study is to describe the features and the results of treatment of patients older than 80 years with HCC.
464 patients with HCC observed from 1991 to 2007 were included into the study. All the patients were evaluated for treatment of HCC in relation to the severity of liver impairment and tumor stage. All the patients included into the study had no evidence of distant metastases. We compared the clinical characteristics and results in patients older or younger than 80 years.
The present study shows that LR and LAT for patients with HCC older than 80 years can achieve good results that are comparable to younger patients. Advanced age should not be considered a contraindication for LAT or LR of HCC; optimal treatment strategy should not be guided by patients' age but by the tumor stage and the degree of liver dysfunction.
This article is published under license to BioMed Central Ltd.