- Research article
- Open Access
- Open Peer Review
Systematic review of information and support interventions for caregivers of people with dementia
- Carl A Thompson†1,
- Karen Spilsbury†1,
- Jill Hall†1,
- Yvonne Birks†1,
- Colin Barnes2Email author and
- Joy Adamson†1
© Thompson et al; licensee BioMed Central Ltd. 2007
- Received: 09 March 2007
- Accepted: 27 July 2007
- Published: 27 July 2007
Dementia is an important health and social care problem and is one of the main causes of disability in later life. The number of families affected by dementia will dramatically increase over the next five decades. Despite the implications for health and social care services in the future, the overwhelming majority of care for people with dementia takes place away from health care settings. Providing informal care for someone with dementia can be psychologically, physically and financially expensive and a range of health service interventions aimed at supporting and providing information to these carers has developed to help carers meet these demands. This review examines whether information and support interventions improve the quality of life of people caring for someone with dementia.
A systematic review examining evidence from randomised controlled trials in which technology, individualised or group-based interventions built around the provision of support and/or information were evaluated.
Forty-four studies were included in the review. Controlling for the quality of the evidence, we found statistically significant evidence that group-based supportive interventions impact positively on psychological morbidity. However, whilst the improvement was unlikely to be due to chance, the clinical significance of this finding should be interpreted tentatively, due to the difficulties in interpreting the standardised mean difference as a measure of effect and the complex aetiology of depression. No evidence was found for the effectiveness of any other form of intervention on a range of physical and psychological health outcomes.
There is little evidence that interventions aimed at supporting and/or providing information to carers of people with dementia are uniformly effective. There is a pressing need to ensure that supportive interventions at the development stage are accompanied by good quality randomised evaluations in which outcomes that are important to clinicians and carers are measured.
- Family Caregiver
- Standardise Mean Difference
- Informal Caregiver
- Caregiver Burden
There are an estimated 7.4 million people living with dementia worldwide and at least 3.7 million with Alzheimer's disease (AD) [1, 2]. In the UK dementia affects 1.1% of the population (683,597 people) . The annual total cost of care for people with late onset dementia in the UK for 2005/6 is estimated to be over €17 billion: this equates to €25,472 per person . In the US, estimated annual costs are $8,064 for formal services and $23,436 for informal care . Informal caregiving constitutes a significant proportion of the care provided to people with dementia. Informal caregivers can be defined as those individuals who provide extraordinary, uncompensated care, predominantly in the home. The role, carried out primarily by family members, involves committing significant amounts of time and energy over months or years, and requires the performance of tasks that may be physically, emotionally, socially, and financially demanding . There are at least 6 million informal caregivers in the UK  and an estimated 22 million in the US . Caring for a family member with dementia is stressful and burdensome, and caregivers' physical and emotional health often suffers as a result . Carer burden is associated with several factors including the relationship to the care recipient, gender, age, ethnicity and care recipient behavioural problems . It is likely then that no single supportive intervention "fits all" caregivers.
A variety of interventions have been developed which aim to offer support for caregivers. Interventions include: training and education programmes, information-technology based support including specialized computer and telephone networks, and formal approaches to planning care which take into account the specific needs of caregivers and people with dementia sometimes using specially designated nurses or other members of the healthcare team. Existing reviews of interventions have tended to focus either on a particular intervention type, for example psychosocial interventions [10, 11], or particular outcomes, such as carer burden [12, 13]. This systematic review aims to assess the effectiveness of interventions based around information and support provision for informal caregivers of people with dementia in community settings. It is worth noting that our focus was on health service interventions rather than the professional group responsible for the intervention delivery. Consequently, whilst the majority of interventions are professionally delivered other non health care professionals may also be involved.
randomised controlled trials.
principal informal caregiver (not a paid professional) and care recipient (diagnosed with dementia) dyad living in the community.
information and/or support intervention.
caregiver outcomes: quality of life, physical and mental health, burden or satisfaction; and patient outcomes: such as activities of daily living or behaviours; health service utilization: such as numbers of in-patient, outpatient or primary health care contacts; economic outcomes: such as time spent on caring activities.
Cochrane Central Register of Controlled Trial
Current Controlled trials
CINAHL (Cumulative Index to Nursing and Allied Health Literature)
SIGLE (Grey Literature in Europe)
ISTP (Index to Scientific and Technical Proceedings)
INSIDE (BL database of Conference Proceedings and Journals)
Aslib Index to Theses (UK and Ireland theses)
Dissertation Abstract (USA)
ADEAR (Alzheimer's Disease Clinical Trials Database)
South Australian Network for Research on Ageing
US Dept of Veterans Affairs Cooperative Studies
National Institutes of Health (NIH)
Schering Health Care Ltd
Hong Kong Health Services Research Fund
Medical Research Council (MRC)
National Research Register
NHS R&D Health Technology Assessment Programme
LILACS:Latin American and Carribbean Health Science Literature
Study selection and data extraction
A single author discarded publications deemed irrelevant on the basis of title and/or abstract. From the refined list of citations, at least two authors independently selected the trials for inclusion if they met the necessary quality criteria. Any disagreements were resolved with a third party. Summary statistics for each trial and each outcome were collected. For continuous data these were mean change from baseline, standard error of mean change, and number of patients for each treatment group at each assessment. Where changes from baseline were not reported, the mean, standard deviation and the number of people in each treatment arm at each time point were extracted (if available). For binary data, the numbers in each treatment group and numbers experiencing the outcome of interest were sought. To allow an intention-to-treat (ITT) analysis, the data was sought irrespective of compliance, whether or not the person was subsequently deemed ineligible, or otherwise excluded from treatment or follow-up. If ITT data were not available in the publications, 'on-treatment' or the data of those who completed the trial were sought and indicated as such. In studies where a cross-over design was used, only data from the first treatment phase after randomisation were eligible for inclusion.
Adequacy of the randomisation process
i) a central allocation process by an office or third party unaware of subject characteristics
ii) pre-numbered packages of support administered to carers sequentially
iii) use of an on-site or coded computer system with a locked, unreadable file with allocation occurring only after carers or patient details are inputted
iv) assignment via scaled, numbered and opaque envelopes
v) other combinations which provide evidence of adequacy in concealment
i) study used list or tables to allocate assignments
ii) use of "envelopes" or" sealed envelopes
iii) simply stating that the study was randomised with no further details
i) by using case numbers, dates of birth, age group, alternation or date of referral and other similar methods
ii) use of any other system in which allocation can be known in advance such as pre-printed lists of random numbers or open computer allocation lists.
Data for each trial were entered into MS Excel spreadsheets and analysed using Revman version 4.2.8. Trials of supportive interventions often measure outcomes using ordinal rating scales. Where the rating scales used in the trials had more than seven categories the data were treated as continuous outcomes and normally distributed.
Many studies failed to report change from baseline or only reported post-intervention means, number of patients and standard deviations. Consequently, we assumed (given satisfactory randomisation) that control and experimental trial arms were comparable at baseline and compared post intervention means or event rates for those studies with sufficiently homegenous interventions.
For the meta-analysis of results of trials we used the weighted mean difference (WMD) when the pooled trials used the same rating scale or test, and the standardised mean difference (SMD) when they used different rating scales or tests. The duration of the trials varied considerably but did not necessitate dividing the meta analysis into smaller time periods with separate meta-analyses for each period. For binary outcomes, such as improvement or no improvement, the odds ratio (OR) was used to measure treatment effect.
In all cases the overall estimate from a fixed-effects model was presented except in cases where there was evidence of substantial heterogeneity between trials in which case a random-effects model was used . I2 statistic was employed to assess the impact of heterogeneity on the meta-analyses; a result of 50% or greater was regarded as substantial . Regardless of statistical heterogeneity meta analysis was only undertaken when the interventions were sufficiently similar in focus and process to allow pooling.
A total of 141 relevant titles and abstracts were provided to authors following the database search by the Editorial Group of the Cochrane Dementia and Cognitive Improvement Group. Following screening, 44 papers (Appendix 1) were included in the final review [A1–A44] and 4 classified as 'pending assessment' (no published results or ongoing) [19–22].
Interventions were classified as technology-based (n = 4), individual (n = 27) or group-based (n = 13). However, within each of these classifications the range of interventions varied considerably and were sometimes not mutually exclusive, for example some trials comprised both group and individual aspects. Pragmatic decisions were made where necessary regarding classification for the purposes of describing studies. However, for the meta-analysis, group intervention was compared to control and individual intervention compared to control, and combined group plus individual interventions were classified according to the predominant component of the intervention [see additional file 1].
Thirteen of the included studies were classified as group based interventions. Eight trials found significant benefits for the interventions compared to controls on some of the outcomes [A6, A9, A11, A19, A20, A24, A26, A38]. Five trials reported no differences between groups on any assessed outcomes [A13, A18, A25, A32, A43].
Twenty seven studies were classified as individual-based interventions. Ten trials found no difference between the groups in the main analysis of the assessed outcomes [A5, A12, A14, A29, A30, A33, A35, A36, A41, A44]. Twelve reported a significant effect for the intervention on some of the assessed outcomes [A3, A4, A7, A15, A16, A21, A22, A28, A31, A34, A39, A40] and one trial reported a significant effect in favour of the control group [A42]. Four studies reported results based on subgroup analyses [A2, A10, A27, A37].
Methodological quality of included studies
The overall quality of included studies was poor. All the included studies were reported as being randomised, however for the majority of studies (n = 41) the method of randomisation was unclear (Category 2) and concealment of allocation was rare. The sample size calculations were poorly reported, with only two of the included trials citing an adequate a priori power calculation [A2, A24].
Over one third of the trials (n = 14) were stated as non-blinded which is perhaps not unusual given the nature of the interventions. However, over 40% did not provide any information on whether blinding (of the participants, the investigators or the outcome assessors) was employed. Only one trial [A37] was conducted in a double-blind manner where the investigators and subjects were blind to the group allocation. Twelve trials [A3, A6, A7, A18, A19, A20, A23, A24, A26, A34, A39, A40] stated that the outcome assessors were blind and one further trial noted that the participants were blind to group allocation [A12].
Most of the included studies reported attrition although this was not always done by group allocation, rather just an overall percentage of all the participants. Attrition ranged from none to 55%. Over two thirds of the studies did not use intention to treat analysis.
A number of the included studies selectively reported outcomes. This was primarily in the form of significant outcomes being reported but a lack of data for other outcomes was also apparent. In addition, many of the studies undertook post-hoc subgroup analyses, often where no significant main effect was detected. There was considerable variation in the length of follow-up amongst the trials although the majority had a maximum follow-up of up to 12 months.
Information and support interventions are delivered via a number of formats. Of these, only group interventions (underpinned by psychoeducational theoretical foundations) appear to positively impact on depression in caregivers. The extent to which these benefits are clinically (rather than just statistically) significant remains uncertain. Putting aside the difficulties of ascertaining clinical significance, considerable caution needs to be exercised in concluding that group based information and support can influence depression. The aetiology of depression is uncertain  but psychological, physical and social factors are often cited as risk factors. Given the lack of impact of information and support interventions on other outcomes that might be expected to correlate with depression (such as the sense of burden that is assumed to accompany caregiving) the apparent impact on depressive symptoms should be interpreted tentatively. Indeed, other researchers  have also found that depression is "surprisingly" unrelated to a sense of burden and satisfaction with life. As well as the difficulties in unpacking the relationship between depression and burden, the interface between statistical and clinical significance presents challenges for clinicians. Specifically, the standardised mean difference presents two major obstacles to interpreting the apparent effects. Firstly, the quantity of the number of standard deviations between the means – the SMD – is not directly useable for decision making . Secondly, the reported trials all used different ordinal scales as the basis for measurement which increases this difficulty. Interpreting the clinical significance of a point estimate shift on a single scale is often difficult, doing so for an average effect size across four different scales (with their associated sensitivities and specificities) is even more precarious. Some studies (A10 and A24) sampled carers on the basis of their psychological morbidity and it might be expected such studies would illustrate the differential effects of interventions. However, whilst – of the five studies included in the meta analysis of group psychoeducational interventions – Marriot [A24] had the second largest effect size (-0.77) it was still only 0.06 SMD greater than the mean for the group (-0.71) and only just statistically significant (95% confidence interval -1.54 – 0.00). This was also a study with only 14 carers in each arm of the comparison. It was not possible to include the Gallagher-Thompson [A10] study in any meta analysis as it presented analysis on the basis of subgroups.
Overall completeness and applicability of evidence
Providing information and support alone is rare in interventions for caregivers of people with dementia – or at least those that are subject to randomised clinical trial evaluation. Often the provision of information and what might be termed 'support' is packaged as part of broader intervention built on theoretical principles of problem solving, coping or psycho-education/training. There are also elements of information provision that are missing from the evidence base, the most obvious being the simple provision of information as a passive activity, for example mass media advertising of support groups, or the targeted provision of educational materials alone.
One of the strengths of pragmatic clinical trials is the commitment to replicating the 'real life' conditions of the interventions. Often the subjects recruited for clinical trials of interventions designed to support caregivers are from the lists of support organisations such as the Alzheimer's Society or from local healthcare clinics. Consequently, the vast majority of the trials in this review fail to capture the effect of the interventions on those caregivers who are not already in receipt of some form of supportive interventions or scrutiny. Similarly, reporting reasons for dropping out of the trials is the exception rather than the norm in the included studies. Therefore the possibility exists that interventions may not be universally popular with caregivers and that caregivers are leaving interventions for reasons that are counterintuitive and hidden.
A further difficulty with the evidence base is the heterogeneity in the outcomes (and associated measures) used in each trial. With the exception of burden and depression the numbers of outcomes measured in studies is vast. Where studies share a common outcome (such as depression) the measures used are often very different (including condition specific measures or measures of general health). Comparing the results of several trials of similar interventions would be made much easier if researchers in the area of supportive interventions would work with those outcomes most sensitive to change and adopt some common shared measures. Initiatives such as the US REACH programme  go someway to addressing this limitation. Perhaps the most significant weakness of the evidence base is the short period of follow up in most clinical trials. Despite the median survival time from diagnosis to death being over 8 years for many dementia patients  the majority of studies follow-up only for 12 months. Follow up periods are also important as it is quite possible that caregiver needs and responses to interventions will alter according to their stage in the caregiving trajectory .
Quality of the evidence
Systematically reviewing trials in the area of support for caregivers of people with dementia is made difficult by the overwhelmingly poor quality of the available evidence and the lack of adherence to what might be termed 'best practice' in trial-based evaluation of effectiveness. The evidence base is characterised by studies in which well described randomisation, blinding of allocation or outcome assessment, intention-to-treat analysis and restriction of analysis to primary outcomes are the exceptions. These indicators of quality are important given the possible impact on the estimated effect size – up to 30% where randomisation alone is unclear .
Non blind outcome assessment increases effect size  and this is more likely for subjective outcomes such as burden ('objective' outcomes such as mortality are less likely to be affected) . Unfortunately, most of the outcomes measured in the area of support for caregivers (such as burden or depression) rely on self report questionnaires – a characteristic which leaves them more prone to social desirability bias.
Very few studies made use of explicit a priori power calculations to ensure that sample sizes were large enough to avoid type 1 and type 2 errors and thus spurious claims of effect. Whilst statistical heterogeneity in the meta-analyses subgroups was rare there was considerable heterogeneity in intervention content. This was particularly so in the extent to which interventions were informed by theoretical frameworks. Some interventions (such as Buckwalter [A2] and Chang [A4]) were designed around explicit models of behaviour and interaction with the caregiving environment, whilst others such as Goodman [A17] appeared more pragmatic.
The poor average quality of the 44 studies included in the review actively reduces the confidence with which conclusions can be drawn relating to effectiveness.
Potential limitations and strengths of the review
This review focused only on randomised trials, taking into account the quality of the evidence involved in our analysis. This is a strength, in that it makes any findings more cautious, and also a possible limitation in that the wealth of non-random, quasi-experimental, evidence available may yield clues regarding the underlying effects of interventions. However, systematic reviews [10, 11] and meta analysis  which have included non-randomised studies suggest, as we do, that there is little evidence to support the idea of universal effectiveness of interventions to improve the lives of caregivers of people with dementia. New evidence in this area is emerging all the time and given the relatively small size of trials in each subgroup it is likely that a large, high quality, clinical trial in a single subgroup may significantly alter any future analysis.
Whilst the quantitative results yielded inconclusive findings, many of the studies we examined reported a number of qualitative findings that suggest that a broader approach to the elucidation of the effects of interventions designed to help caregivers might yield some meaningful results and areas for more rigorous evaluation in future research. For example, Robinson [A36] highlights the ability to share perceptions and solve care-related problems within caregiver groups as an important qualitative dimension of the experience of receiving the intervention. Brennan [A1] in her report of the effectiveness of a computer network found that one of the reasons for drop-out was that 'the computer' frightened a subject. Ongoing work on systematically reviewing qualitative findings should help elucidate these experiences and could help inform the development of measures of effect with greater internal validity.
The recent Dementia UK report  recommends carer support packages and in particular psychological therapies that include carer training and support groups. Our review suggests that there is no evidence that information and support-based interventions for caregivers of people with dementia are uniformly effective. Very limited evidence exists supporting the argument that information and support, in the context of group psychoeducational approaches, might have a statistically significant positive effect on depression. However, the small size of the studies involved and the considerable variations in content within the subgroups mean that this conclusion should be interpreted very cautiously. Moreover, despite the statistical significance of the result, the clinical significance of the improvement remains uncertain. The relationship to any possible harms (such as an increased sense of burden as a result of having to receive the intervention) also remains unknown.
For any policy maker or service planner in the area of carer support there are fundamental questions that require answers: "which carers are most likely to benefit from our service?"; "in what circumstances will this package be effective?"; "at what stage in the caring trajectory should we introduce this service to deliver the most benefit to carers?". Our research suggests that evidence based decision makers will have to wait some time for the answers to these vital questions. The quality of the existing evidence base, as revealed in this review, simply does not allow evidence-based estimates of such effects. Caring is an emotive subject, and addressing the possibility that what is provided by health services to help carers may not be as beneficial as we would like to believe is a challenging research agenda; but perhaps more than ever, there really is a need for radical scrutiny of what exists and what we can learn from well constructed evaluations.
The authors would like to thank the editorial staff of the Cochrane Dementia and Cognitive Improvement Collaborative Review Group for their assistance with searching for this review and commenting on earlier drafts. Thanks also to authors of papers included in the review who provided additional information.
- Hofman A, Rocca WA, Brayne C, Breteler MM, Clarke M, Cooper B, Copeland JRM, Dartigues JF, Da Silva Droux A, Hagnell O, Heeren TJ, Engedal K, Jonker C, Lindesay J, Lobo A, Mann AH, Molska PK, Morgan K, O'Connor DW, Sulkava R, Kay DWK, Amaducci L, for the Eurodem Prevalence Research Group: The Prevalence of Dementia in Europe: A Collaborative Study of 1980–1990 Findings. International Journal of Epidemiology. 1991, 20 (3): 736-48. 10.1093/ije/20.3.736.View ArticlePubMedGoogle Scholar
- Alzheimer's Disease International: The prevalence of dementia: Fact Sheet 3. 1999Google Scholar
- PSSRU: Dementia UK: A report to the Alzheimer's Society on the prevalence and economic cost of dementia in the UK produced by King's College London and London School of Economics. 2007, London: Alzheimer's SocietyGoogle Scholar
- Harrow BS, Mahoney DF, Mendelson AB, Ory MG, Coon DW, Belle SH, Nichols LO: Variation in cost of informal caregiving and formal-service use of people with Alzheimer's disease. Am J Alzheimer's Dis Other Demen. 2004, 19: 299-308. 10.1177/153331750401900507.View ArticleGoogle Scholar
- Biegel D, Sales E, Schulz R: Family caregiving in chronic illness: Heart disease, cancer, stroke, Alzheimer's disease, and chronic mental illness. 1991, Newbury Park, CA:Sage PublicationsGoogle Scholar
- Census 2001: First results on population for England and Wales. 2002, London: Stationery OfficeGoogle Scholar
- US Dept of Health and Human Services: The future supply of long term care workers in relation to the aging baby-boom generation. 2003, Washington, DC: Department of Health and Human Services, [http://www.aspe.hhs.gov/daltcp/reports/ltcwork.pdf]Google Scholar
- Wills W, Soliman A: Understanding the needs of the family carers of people with dementia. Mental Health Rev. 2001, 6: 25-28.View ArticleGoogle Scholar
- Haley WE, Gitlin LN, Wisniewski SR, Mahoney DF, Coon DW, Winter L, Corcoran M, Schinfeld S, Ory M: Well-being, appraisal, and coping in African-American and Caucasian dementia caregivers: findings from the REACH study. Aging & Mental Health. 2004, 8: 316-329. 10.1080/13607860410001728998.View ArticleGoogle Scholar
- Cooke DD, McNally L, Mulligan KT, Harrison MJG, Newman SP: Psychosocial interventions for caregivers of people with dementia: a systematic review. Aging & Mental Health. 2001, 5 (2): 120-135.View ArticleGoogle Scholar
- Pusey H, Richards D: A systematic review of the effectiveness of psychosocial interventions for carers of people with dementia. Aging & Mental Health. 2001, 5 (2): 107-119. 10.1080/13607860120038302.View ArticleGoogle Scholar
- Acton GJ, Kang J: Interventions to reduce the burden of caregiving for an adult with dementia: a meta-analysis. Research in Nursing & Health. 2001, 24: 349-360. 10.1002/nur.1036.View ArticleGoogle Scholar
- Torti FM, Gwyther LP, Reed SD, Friedman JY, Schulman KA: A multinational review of recent trends and reports in dementia caregiver burden. Alzheimer Dis Assoc Disord. 2004, 18 (2): 99-109. 10.1097/01.wad.0000126902.37908.b2.View ArticlePubMedGoogle Scholar
- Higgins JPT, Green S: Cochrane Handbook for Systematic Reviews of Interventions 4.2.6. 2006, The Cochrane Library, Chichester, John Wiley & Sons Ltd;, [http://www.cochrane.org/resources/handbook/Handbook4.2.6Sep2006.pdf]4Google Scholar
- NHS Centre for Reviews & Dissemination: Undertaking Systematic Reviews of Research on Effectiveness: CRD guidelines for those Carrying Out or Commissioning Reviews. 2001, CRD Report Number 4. York: CRD, 2Google Scholar
- Schulz K, Chalmers I, Hayes RJ, Altman DG: Empirical Evidence of Bias, Dimensions of Methodological Quality Associated with Estimates of Treatment Effects in Controlled Clinical Trials. Journal of the American Medical Association. 1995, 273: 408-12. 10.1001/jama.273.5.408.View ArticlePubMedGoogle Scholar
- Sutton A, Abrams K, Jones K, Sheldon TA, Song F: Systematic reviews of trials and other studies. Health Technology Assessment. 1998, 2 (19): 1-272. [http://www.ncchta.org/fullmono/mon219.pdf]PubMedGoogle Scholar
- Higgins JPT, Thompson SG, Deeks JJ, Altman DG: Measuring inconsistency in meta-analyses. BMJ. 2003, 327: 557-560. 10.1136/bmj.327.7414.557.View ArticlePubMedPubMed CentralGoogle Scholar
- Charlesworth G: Can cognitive therapy reduce emotional burden in depressed carers of people with Alzheimer's and improve the quality of life for caregiver/care-recipient dyads?. National Research Register. 2000Google Scholar
- Connell CM, Janevic MR, Hudson ML: Effects of a telephone-based exercise program for female spouse caregivers of dementia patients. Proceedings of the 8th International Conference on Alzheimer's Disease and Related Disorders. Stockholm, Sweden, July 20–25 2002; [Abstract No 1996]Google Scholar
- Mittelman MS: Counseling education and support for family caregivers of dementia patients: The similarities and differences between two effective psychosocial interventions and plans for a multinational collaborative study. Proceedings of the 9th Congress of the International Psychogeriatric Association. Vancouver, Canada, Aug 15–20 1999; [Abstract no. 33]Google Scholar
- Charlesworth G: Does befriending by trained lay workers improve psychological well-being and quality of life for carers of people with dementia and at what cost: A randomised controlled trial. National Research Register. 2004Google Scholar
- Butler R, Carney S, Cipriani A, Geddes J, Hatcher S, Price J, Von Korff M: Depressive Disorders: Clinical Evidence. 2004, [http://www.clinicalevidence.com/ceweb/conditions/meh/1003/1003_background.jsp#aetiology]Google Scholar
- McConaghy R, Caltabiano ML: Caring for a person with dementia: Exploring relationships between perceived burden, depression, coping and well-being. Nursing and Health Sciences. 2005, 7: 81-91. 10.1111/j.1442-2018.2005.00213.x.View ArticlePubMedGoogle Scholar
- Cochrane Collaboration: Meta-analysis of continuous data: Measuring the effect of treatment. 2002, [http://www.cochrane-net.org/openlearning/HTML/modA1-4.htm]Google Scholar
- Resources for Enhancing Alzheimer's Caregiver Health: [http://www.edc.gsph.pitt.edu/reach/]
- Brookmeyer R, Corrada MM, Curriero FC, Kawas C: Survival Following a Diagnosis of Alzheimer Disease. Arch Neurol. 2002, 59: 1764-1767. 10.1001/archneur.59.11.1764.View ArticlePubMedGoogle Scholar
- Bond MJ, Clark MS, Davies S: The quality of life of spouse dementia caregivers: changes associated with yielding to formal care and widowhood. Social Science and Medicine. 2003, 57: 2385-2395. 10.1016/S0277-9536(03)00133-3.View ArticlePubMedGoogle Scholar
- Juni P, Altman DG, Egger M: Assessing the quality of randomised controlled trials. Systematic reviews in Health Care. Edited by: Egger M, Davey-Smith G, Altman DG. 1995, London: BMJ, 87-108.Google Scholar
- Knight BG, Lutzky SM, Macofsky-Urban F: A meta-analytic review of interventions for caregiver distress: recommendations for future research. Gerontologist. 1993, 33 (2): 240-8.View ArticlePubMedGoogle Scholar
- The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2318/7/18/prepub
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