|
Baseline characteristic
| |
With any fracture
|
Without fracture
|
p-value
|
|---|
|
(n = 145)
|
(n = 8019)
|
(log-rank test)
|
|---|
|
N (%)
|
N (%)
| |
|---|
|
Sex
|
Male
|
55 (37.9)
|
5163 (64.4)
|
<.001
|
| |
Female
|
90 (62.1)
|
2854 (35.6
| |
|
Age
|
<65 yrs
|
23 (15.9)
|
4276 (53.3)
|
<.001
|
| |
> = 65 yrs
|
122 (84.1)
|
3743 (46.7)
| |
|
Ethnicity
|
Western European
|
105 (78.9)
|
3171 (42.3)
|
<.001
|
| |
Oriental
|
15 (11.3)
|
1898 (24.7)
| |
| |
South Asian
|
7 (5.3)
|
2046 (26.6)
| |
| |
Other
|
6 (4.5)
|
566 (7.4)
| |
|
Oxford Handicap Score
|
> = 3
|
35 (24.7)
|
1859 (23.8)
|
0.18
|
| |
<3
|
107 (75.4)
|
5952 (76.2)
| |
|
Smoking (ever)
|
Yes
|
72 (49.7)
|
3947 (49.9)
|
0.43
|
| |
No
|
73 (50.3)
|
3966 (50.1)
| |
|
Alcohol (any)
|
Yes
|
54 (37.2)
|
2269 (28.3)
|
0.20
|
| |
No
|
91 (62.8)
|
5748 (71.7)
| |
|
Diabetes
|
Yes
|
24 (16.6)
|
1875 (23.7)
|
0.21
|
| |
No
|
121 (83.5)
|
6047 (76.3)
| |
|
Stroke
|
Yes
|
28 (19.3)
|
1254 (15.8)
|
0.28
|
| |
No
|
117 (80.7)
|
6664 (84.2)
| |
|
Myocardial infarction
|
Yes
|
15 (10.3)
|
583 (7.4)
|
0.33
|
| |
No
|
130 (89.7)
|
7317 (92.6)
| |
|
Hypertension
|
Yes
|
105 (72.4)
|
5632 (71.1)
|
0.45
|
| |
No
|
40 (27.6)
|
2285 (28.9)
| |
|
Depression
|
Yes
|
16 (16.0)
|
528 (7.4)
|
0.003
|
| |
No
|
84 (84.0)
|
6650 (92.6)
| |
|
Antidepressant medication
|
Yes
|
24 (16.6)
|
536 (6.8)
|
<.001
|
| |
No
|
121 (83.5)
|
7332 (93.2)
| |
|
Corticosteroid medication
|
Yes
|
3 (2.1)
|
47 (0.6)
|
0.011
|
| |
No
|
142 (97.9)
|
7972 (99.4)
| |
|
Any Osteoporosis Medication *
|
Yes
|
23 (15.9)
|
556 (6.9)
|
<.001
|
| |
No
|
122 (84.1)
|
7463 (93.1)
| |
|
Homocysteine level at baseline †
| |
(n = 40)
|
(n = 1165)
|
0.43
|
|
mean (SD)
|
14.2 (6.2)
|
14.3 (8.6)
|
- * Including Calcium, Vitamin D, Bisphosphonates and Hormone replacement therapy;
- † Not all participants had homocysteine levels measured at Baseline.
