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The relationship between increased body mass index and frailty on falls in community dwelling older adults
© Sheehan et al.; licensee BioMed Central Ltd. 2013
Received: 27 November 2012
Accepted: 26 November 2013
Published: 6 December 2013
The global population is becoming older and more overweight. The inter-relationship between frailty and falls is often seen in the older adult and is associated with poor health outcomes. Little is known about this relationship for those with excess body mass. This study aimed to assess the relationships between BMI, frailty and falls.
Frailty, body mass index, clinical and demographic characteristics were assessed at baseline for 606 community dwelling adults aged 60 years and older. Falls were assessed prospectively with a semi-structured telephone interview two years later.
An increase in BMI contributed significantly to the identification of frail (Odds Ratio: 4.4; 95% Confidence Interval: 1.4, 13.6) older adults. A total of 346 falls by 148 participants were reported at follow up. Those with an increased BMI were significantly less likely to have experienced a fall between baseline and follow up assessments (p = 0.03). Despite these opposing trends a BMI greater than or equal to 30.0 kg.m2 did not alter the relationship between falls and frailty for the current cohort.
This is the first study to assess the falls-frailty relationship for those with an increased BMI. Obesity was found to be protective against falling but not specifically in frail older adults.
With declining fertility and increasing life expectancy for most regions of the world, the global age structure has shifted from a younger to an older population . From 1950 to 2000 the number of adults over the age of 60 increased by 401 million . This trend is expected to continue with projected figures for 2050 of two billion adults over the age of 60 . In Europe 66.1% of men and 53.8% of women over the age of 50 were recently reported as overweight or obese . A 50% increase in the global proportion of adult obesity has been noted from 1980 to 2008 . These figures suggest that the global population is becoming increasingly older and more overweight. This changing population demographic has undisputable implications with regard to health and economic costs.
Falls have been shown to result in increased morbidity and are responsible for over 17 million disability-adjusted life years lost . One in three adults over the age of 65 will experience at least one fall each year . A fall can have significant adverse outcomes including injury, hospitalisation, and admission to long term care, the development of fear of falling, activity restrictions, social isolation, reduced self-efficacy and quality of life . Fried et al., described frailty as ‘…a clinical syndrome in which three or more of the following criteria were present: unintentional weight loss (10 lbs in past year), self-reported exhaustion, weakness (grip strength), slow walking speed, and low physical activity’. A history of falls in the older adult is regularly associated with the presence of frailty, whereby those classified as pre-frail/frail have a higher propensity to falling [7–10].
Recently a ‘U’ shaped correlation between obesity and frailty was reported, suggesting those who are underweight (body mass index (BMI) < 18.5) and those who are obese (BMI > 30) were more likely to present as frail . This increased susceptibility towards frailty for obese older adults was surprising as frailty is often considered a wasting disorder . Perhaps the association between obesity and frailty is the result of confounding, as obesity is often linked with slow walking speed, reduced physical activity levels, weakness and exhaustion [13–16]. Blaum et al., outlined several plausible physiological mediators of a relationship between frailty and obesity; these included the presence of an increased inflammatory marker C-reactive protein, and low antioxidant capacity with reduced carotenoids for their obese group.
Two prospective studies investigating the relationship between falls and obesity in the older adult have yielded conflicting results [18, 19]. Himes & Reynolds  noted a relationship between falls and obesity, whereby the greater the extent of the obesity, the higher the falls risk. In contrast, Rosenblatt & Grabiner  reported similar prospective falls frequencies of 64.3% and 64.7% for obese and healthy weight older women respectively.
To determine the cross sectional relationship between BMI and frailty in community dwelling older adults.
To determine the relationship between baseline frailty status and number of falls at two year follow up.
To determine if body mass index influences the relationship between falls and frailty in community dwelling older adults.
A convenience sample from the Technology Research for Independent Living (TRIL) longitudinal study on ageing (http://www.trilcentre.org) was used for this research. Those community dwelling, ≥ 60 years of age, able to walk independently (with/without a walking aid), cognitively intact and able to provide informed consent were included in the TRIL cohort. Participants were recruited from St. James’s Hospital, or self-referred. Ethical approval was received from the St. James’s Hospital/Adelaide and Meath Hospital, incorporating the National Children’s Hospital Research Ethics Committee (approval reference number 2007/06/13). Participants completed an extensive baseline bio psychosocial assessment at the TRIL Clinic, St. James’s Hospital Dublin, Ireland. A semi-structured phone interview was conducted by a research nurse approximately two years following this assessment.
Age, gender and social class were documented. Social class was determined using the Irish Central Statistics Office Census Social Class Classification (http://www.cso.ie). This seven point classification is based on a person’s occupation whereby professional workers are assigned a score of one, managerial and technical workers a score of two, non-manual workers three, skilled manual workers four, semi-skilled workers five, unskilled six, and all others gainfully occupied and unknown seven.
Weight and height were measured according to standardised protocols to enable the calculation of BMI. International classification of BMI sub-groups were adopted whereby underweight was identified as a BMI of < 18.5 kg.m2, healthy weight as a BMI of 18.5 to <25 kg.m2, overweight as a BMI of 25 to <30 kg.m2, and obese a BMI of >30 kg.m2. Polypharmacy was defined as the regular use of four or more prescription medications . The presence of co-morbidities associated with falls and frailty were documented during the baseline comprehensive assessment, and were confirmed with hospital medical records. These included osteoarthritis, Parkinson’s disease, diabetes, congestive cardiac failure, chronic obstructive pulmonary disease, peripheral vascular disease, cancer, hypertension, and atrial fibrillation.
Exhaustion: Present for those who answered ‘yes’ to ‘In the last week, did you feel in at least three days that everything you did was an effort?’ and/or ‘ In the last week did you feel in at least three days that you could not get going?’.
Weakness: Present for those in the lowest 20th percentile of grip strength stratified by gender and quartiles of BMI.
Gait velocity: Present for those in the lowest 20th percentile of gait velocity stratified by gender as measured by the GAITRite™ walkway system.
Physical activity: Present for those in the lowest 20th percentile of the number of hours spent walking outdoors per week stratified by gender.
Weight loss: Present for those who reported at least 1 kg of unintentional weight loss in the three months prior to their assessment.
Those who met none of the criteria were classified as robust, those who met 1–2 criteria pre-frail and those who met 3–5 criteria frail.
Falling was defined as a sudden, unintentional change in position causing an individual to land on a lower level, on an object, the floor, the ground or other surface . Participants were contacted two years after the baseline assessment and an interview to determine the number of falls incurred was conducted. Participants who experienced one fall in the follow up period were classified as fallers. Participants who reported two or more falls in the follow-up period were classified as recurrent fallers.
Demographic and clinical characteristics, frailty proportions and indicators were expressed in terms of mean and standard deviations, ratios, and positive sample proportions for the total sample and for the sample according to follow-up faller status. Statistical tests for trends associated with faller status were computed using logistic regression for categorical variables.
Multi-nominal logistic regression was employed to determine the cross sectional relationship between BMI and frailty, and the association between baseline frailty status and falls at follow up. Analyses were adjusted for potential demographic and clinical confounders. Finally a multi-nominal logistic regression between baseline frailty and falls at follow-up stratified by BMI was completed. Alpha was set at 0.05 for all analyses.
Six hundred and six participants completed the baseline assessment. Of the 606 participants contacted at follow-up 85 did not complete the telephone interview for the following reasons: 30 were deceased, five were admitted to long term care, nine had no recall of the baseline assessment and were deemed unable to give informed consent, 29 declined, and 12 could not be contacted. At follow up 546 participants were included in the analysis. Those who were not followed up were significantly older, frailer and demonstrated a higher proportion of polypharmacy, Parkinson’s disease, chronic obstructive pulmonary disease, peripheral vascular disease, cancer and atrial fibrillation (p ≤ 0.05). 13 participants were classified as underweight (BMI < 18.5kg.m2), due to the small sample and the current focus on those with a higher BMI they were excluded from the regression analyses.
Baseline demographics, clinical measures and frailty indicators for the total sample and the sample stratified by faller status at follow up
Faller status at follow up
All (n = 606)
Not followed up (n = 85)
Non faller (n = 373)
Faller (n = 85)
Recurrent faller (n = 63)
Age (years) mean(SD) †
Social class mean(SD)
BMI (kg.m2) mean (SD)
Congestive cardiac failure %‡
Chronic obstructive pulmonary disease %
Peripheral vascular disease %‡
Atrial fibrillation %
Frailty Indicators %
Weight loss %
Slow walking velocity %‡
Decreased activity levels %
Cross tabulations between BMI category, and frailty criteria
18.5 to <25 kg.m2(n = 606)
25 to <30 kg.m2(n = 254)
>30 kg.m2(n = 124)
Frailty Indicators %
Weight loss %‡
Reduced walking velocity %†
Decreased activity levels %*
Multinominal logistic regression assessing the relationship between BMI, pre-frailty and frailty
Odds ratio (95% confidence interval)
BMI ≥30.0 kg.m2
BMI 25.0-29.9 kg.m2
Congestive cardiac failure
Peripheral vascular disease
Chronic obstructive pulmonary disease
A total of 346 falls by 148 participants were reported at the follow up phone interview. 85 experienced a single fall, and 63 experienced multiple falls. A positive faller status at follow up was significantly associated with the frailty indicators weakness (p = 0.02), reduced gait velocity (p = 0.02) and exhaustion (p = 0.03) (Table 1). Baseline frailty status was a significant predictor of recurrent faller (Odds Ratio: 1.4; 95% CI: 1.1, 1.6) status at follow-up assessment. With adjustment for social class, polypharmacy, atrial fibrillation, hypertension, congestive cardiac failure, diabetes, chronic obstructive pulmonary disease, peripheral vascular disease, osteoarthritis, cancer and Parkinson’s disease the relationship between recurrent falls and frailty was marginally reduced (Odds Ratio: 1.3; 95% CI: 0.8, 1.6).
Multinominal logistic regression for the relationship between falls and frailty stratified by BMI
Odds ratio (95% Confidence interval)
1.1(1.0, 1.1) †
0.8 (0.4, 1.5)
BMI ≥30.0 kg.m2
0.9(0.8, 1.0) ‡
BMI 25.0-29.9 kg.m2
BMI 18.5-24.99 kg.m2
This is the first study to assess the falls-frailty relationship stratified by BMI. Obesity was inversely related to falls and was positively associated with frailty, but from our data did not seem to modify the relationship between falls and frailty. Obesity was found to be protective against falling but not specifically in frailer older adults.
With increased BMI, an increase in the sample proportions of the frailty criteria exhaustion, weakness, reduced walking velocity, and decreased activity levels were noted. A negative association between BMI and weight loss was found. For the current study BMI demonstrated a strong positive association with frailty status at baseline. The relationship persisted after adjustment for potential demographic and clinical confounders. This is in contrast to previous research which describes a ‘U’ shaped relationship whereby those with a BMI of 25.0-29.9 kg.m2 were less likely to present as frail than their healthy weight or obese peers [17, 23]. Age, gender, congestive cardiac failure and peripheral vascular disease were also significantly associated with frailty for the current cohort.
Fried’s weight loss criterion is believed to reflect wasting in older adults . For the current study it was noted that an increased BMI was negatively associated with weight loss. This would suggest that those with a higher BMI are less susceptible to wasting, as defined by weight loss. However sarcopenia has been shown to affect older adults independent of their BMI [23, 24]. It may be hypothesised that ‘true’ wasting, sarcopenia or muscle loss, may be better reflected by the weakness criterion for those with an increased BMI.
Previous studies on the relationship between BMI and falling indicate that increased BMI increases the risk of falls [18, 25] or adds no additional risk of falls . The current study found that for an increase in BMI there was in fact a reduced risk of falling for older adults. Sharkey et al.,  noted that for older adults with severe obesity (BMI ≥ 35kg.m2) both static and dynamic stability were impaired. Overweight and obese older adults have been shown to adopt a more tentative gait pattern, with a slower walking velocity and an increased base of support . As a result of these adaptations, stability is in fact improved . These alterations may inadvertently represent a protective effect against falls. In addition those with obesity were more likely to meet the reduced physical activity frailty criterion. This would suggest that adults with obesity present with less opportunity to fall as they are less physically active.
Overweight and obese participants were identified as more likely to be frail, but less likely to experience a fall. This was surprising given the general consensus of the association between falls and frailty in older adults [7–10]. The results of the multinominal logistic regression analyses stratified by BMI indicated that BMI did not clearly influence the falls-frailty relationship for the current cohort. The positive relationship between frailty and falling was evident for the full sample. In the stratified analyses, the relationship between frailty and recurrent falling was strongest in the overweight group, however frailty was inversely associated with single falls in this group. Similarly there was a clear, if non-significant, positive relationship between frailty and single falls in normal weight participants combined with a trend towards a negative relationship with recurrent falls. The lack of coherent pattern across categories suggests these apparent differences maybe be more likely to be due to chance differences in the number of falls in each group, rather than a clear effect of BMI on the relationship between frailty and falling in this sample.
There are some limitations to this study. Frailty was not longitudinally assessed, and therefore the temporal relationship between changes in frailty and BMI cannot be determined. Falls history was recorded at a two year follow up assessment. This history was self-reported and may have led to an underreporting of falls and an underestimation of the effects presented here. There are many definitions of frailty. For the present study we chose to focus on physical frailty, as defined by the frailty phenotype. While this model is widely accepted, it allows only a broad categorisation of levels of frailty in comparison to the finer gradation of individual risk possible with deficit accumulation models . For the stratified analyses the relatively small sample sizes and number of falls within each subgroup may have limited the ability to detect effects.
Frailty is traditionally perceived as a wasting disorder associated with an increased risk of falls, morbidity, hospitalisation, and mortality . This study aimed to assess the falls-frailty relationship for adults with increased BMI. It was found that those with an increased BMI were more likely to present as frail and less likely to fall. Despite these opposing trends a BMI ≥30.0 kg.m2 did not clearly alter the relationship between falls and frailty in the current cohort.
This research was completed as part of a wider programme of research within the TRIL Centre, (Technology Research for Independent Living). The TRIL Centre is a multi-disciplinary research centre, bringing together researchers from Trinity College Dublin, University College Dublin, National University of Ireland, Galway and Intel Ireland http://www.trilcentre.org. This research was funded by Intel Ireland, GE Healthcare and IDA Ireland.
- United Nations: World Population Prospects: The 2000 Revisions. 2001c, http://www.un.org/esa/population/publications/worldageing19502050/,Google Scholar
- Andreyeva T, Michaud PC, van Soest A: Obesity and health in Europeans ages 50 and above. Public Health. 2007, 121: 497-509. 10.1016/j.puhe.2006.11.016.View ArticlePubMedGoogle Scholar
- WHO. 2012, http://www.who.int/mediacentre/factsheets/fs311/en/,
- WHO. 2012b, http://www.who.int/mediacentre/factsheets/fs344/en/index.html,
- Berg WP, Alessio HM, Mills EM, Tong C: Circumstances and consequences of falls in independent community-dwelling older adults. Age Ageing. 1997, 26 (4): 261-268. 10.1093/ageing/26.4.261.View ArticlePubMedGoogle Scholar
- Fried LP, Tangen CM, Walston J, et al: Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci. 2001, 56: 146-156. 10.1093/gerona/56.3.M146.View ArticleGoogle Scholar
- Speciale S, Turco R, Magnifico F, Bellelli G, Trabucchi M: Frailty is the main predictor of falls in elderly patients undergoing rehabilitation training. Age Ageing. 2004, 33: 84-85.View ArticlePubMedGoogle Scholar
- Fugate WN, LaCroix AZ, Gray SL, et al: Frailty: emergence and consequences in women aged 65 and older in the women’s health initiative observational study. JAGS. 2005, 53: 1321-1330. 10.1111/j.1532-5415.2005.53405.x.View ArticleGoogle Scholar
- Ensrud KE, Ewing SK, Taylor BC, et al: Frailty and risk of falls, fracture, and mortality in older women: the study of osteoporotic fractures. J Gerontol A Biol Sci Med Sci. 2007, 62: 744-751. 10.1093/gerona/62.7.744.View ArticlePubMedGoogle Scholar
- Nowak A, Hubbard RE: Falls and frailty: lessons from complex systems. J R Soc Med. 2009, 102: 98-102. 10.1258/jrsm.2009.080274.View ArticlePubMedPubMed CentralGoogle Scholar
- Hubbard RE, Lang IA, Llewellyn DJ, Rockwood K: Frailty, body mass index, and abdominal obesity in older people. J Gerontol A Biol Sci Med Sci. 2010, 65: 377-381.View ArticlePubMedGoogle Scholar
- Roubenoff R: The pathophysiology of wasting in the elderly. J Nutr. 1999, 129: 256S-259S.PubMedGoogle Scholar
- Ko S, Stenholm S, Ferrucci L: Characteristic gait patterns in older adults with obesity – results from the Baltimore longitudinal study of aging. J Biomech. 2010, 43: 1104-1110. 10.1016/j.jbiomech.2009.12.004.View ArticlePubMedPubMed CentralGoogle Scholar
- Fitzgerald SJ, Kriska AM, Pereira MA, DeCourten MP: Associations among physical activity, television watching, and obesity in adult Pima Indians. Med Sci Sport Exer. 1997, 29: 910-915. 10.1097/00005768-199707000-00010.View ArticleGoogle Scholar
- Jackson AW, Lee DC, Sui X, et al: Muscular strength is inversely related to prevalence and incidence of obesity in adult men. Obes. 2010, 18: 1988-1995. 10.1038/oby.2009.422.View ArticleGoogle Scholar
- Bryant MJ, Stevens J, Truesdale KP, Mosley T, Chambless L: Obesity and vital exhaustion: analysis of the atherosclerosis risk in the communities study. Obes. 2008, 16: 1545-1551. 10.1038/oby.2008.248.View ArticleGoogle Scholar
- Blaum CS, Xue QL, Michelon E, Semba RD, Fried LP: The association between obesity and the frailty syndrome in older women: the women’s health and ageing studies. JAGS. 2005, 53: 927-934. 10.1111/j.1532-5415.2005.53300.x.View ArticleGoogle Scholar
- Himes CL, Reynolds SL: Effect of obesity on falls, injury, and disability. JAGS. 2012, 60: 124-129. 10.1111/j.1532-5415.2011.03767.x.View ArticleGoogle Scholar
- Rosenblatt NJ, Grabiner MD: Relationship between obesity and falls by middle-aged and older women. Arch Phys Med Rehabil. 2012, 93: 718-722. 10.1016/j.apmr.2011.08.038.View ArticlePubMedGoogle Scholar
- Denneboom W, Dautzenberg MG, Grol R, De Smaet PA: Analysis of polypharmacy in older patients in primary care using a multidisciplinary expert panel. Br J Gen Pract. 2006, 56: 504-510.PubMedPubMed CentralGoogle Scholar
- Romero-Ortuno R, Cogan L, O’Shea D, Lawlor BA, Kenny RA: Orthostatic haemodynamics may be impaired in frailty. Age Ageing. 2011, 40: 576-583. 10.1093/ageing/afr076.View ArticlePubMedGoogle Scholar
- Tinetti M, Baker D, Dutcher J, Vincent J, Rozett R: Reducing the risk of falls among older adults in the community. 1997, Berkeley: Peacable Kingdom PressGoogle Scholar
- Villareal DT, Banks M, Siener C, Sinacore DR, Klein S: Physical frailty and body composition in obese elderly men and women. Obes Res. 2012, 12: 913-920.View ArticleGoogle Scholar
- Estrada M, Kleppinger A, Judge JO, Walsh SJ, Kuchel GA: Functional impact of relative versus absolute sacropenia in healthy older women. JAGS. 2007, 55: 1712-1719. 10.1111/j.1532-5415.2007.01436.x.View ArticleGoogle Scholar
- Fjeldstad C, Fjeldstad AS, Acree LS, Nickel KJ, Gardner AW: The influence of obesity on falls and quality of life. Dyn Med. 2008, 7: 4-10.1186/1476-5918-7-4.View ArticlePubMedPubMed CentralGoogle Scholar
- Sharkey JR, Ory MG, Branch LG: Severe elder obesity and 1-year diminished lower extremity physical performance in homebound older adults. JAGS. 2006, 54: 1407-1413. 10.1111/j.1532-5415.2006.00842.x.View ArticleGoogle Scholar
- Menz HB, Lord SR, Fitzpatrick RC: Age-related differences in walking stability. Age Ageing. 2003, 32: 137-142. 10.1093/ageing/32.2.137.View ArticlePubMedGoogle Scholar
- Rockwood K, Andrew M, Mitnitski A: A comparison of two approaches to measuring frailty in elderly people. J Gerontol A Biol Sci Med Sci. 2007, 7: 738-743.View ArticleGoogle Scholar
- Rockwood K, Stadnyk K, MacKnight C, McDowell I, Herbert R, Hogan DB: A brief clinical instrument to classify frailty in elderly people. Lancet. 1999, 353: 205-206. 10.1016/S0140-6736(98)04402-X.View ArticlePubMedGoogle Scholar
- The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2318/13/132/prepub
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