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Lynch II syndrome: a case report
BMC Geriatrics volume 11, Article number: A58 (2011)
Lynch syndrome is an autosomal dominant cancer susceptibility syndrome that accounts for approximately 2–4% of all colorectal cancers (CRCs) and is caused by germline mutations of mismatch repair (MMR) genes [1–4]. It is characterized by an early onset of predominantly CRC and endometrial cancer (EC) as well as cancers of the stomach, small bowel, ureter and renal pelvis.
Materials and methods
We report a case of a patient 60 years old affected by synchronous primary cancers of the sigma and stomach diagnosed by TC. The patient had previously been operated on for the right hemicolectomy for adenocarcinoma, and hysterectomy for cancer. During hospitalization the patient has undergone surgery on the left hemicolectomy and a total gastrectomy. The patient underwent chemotherapy. Currently the patient is receiving chemotherapy for local recurrence.
As a result of genetic study, the patient was found to be the first to have this mutation.
Surgery remains the front-line therapy for HNPCC. There is an ongoing controversy over the benefit of 5-fluorouracil-based adjuvant therapies for HNPCC-related colorectal tumors, particularly those in stages I and II. After reporting a null finding from their randomized controlled trial of aspirin (ASA) to prevent against the colorectal neoplasia of Lynch Syndrome, Burn and colleagues have recently reported new data, representing a longer follow-up period than reported in the initial NEJM paper. These new data demonstrate a reduced incidence in Lynch Syndrome patients who were exposed to at least four years of high-dose aspirin, with a satisfactory risk profile. These results have been widely covered in the media; future studies will look at modifying (lowering) the dose (to reduce risk associated with the high dosage of ASA).
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Scotto, B., Spera, E., Merola, G. et al. Lynch II syndrome: a case report. BMC Geriatr 11, A58 (2011). https://doi.org/10.1186/1471-2318-11-S1-A58
- Endometrial Cancer
- Germline Mutation
- Lynch Syndrome
- Total Gastrectomy