Use of elder donors for cadaveric single kidney transplantation: a new evolution or an inacceptable risk?
© Melandro et al; licensee BioMed Central Ltd. 2011
Published: 24 August 2011
Organ shortage and long waiting times represent relevant issues in modern kidney transplantation . Expansion of the donor pool using Extended Criteria Donors (ECD) represents a way to partially resolve these limits. ECDs are defined by UNOS as ≥ 60-year aged donors or 50-59-year aged donors with at least 2 of 3 risk factors (pre-procurement serum creatinine >1.4 mg/dl, cerebrovascular accident and history of hypertension) . However, use of ECD seems to be related to worse results in terms of graft function and survival . Moreover, no data exist with regard to comparison between over-60 and 50-59-year aged donors. The aim of this study is to analyze the cohort of ECD transplants performed in our Department, evaluating the role of donor age on results.
Materials and methods
From January 2004 to May 2009, 95 single kidney transplantations using ECDs were performed. The entire cohort was stratified in 2 groups: Group A (50-59 years, n=26) and Group B (≥ 60 years, n=69). Donor, recipient and transplant characteristics were compared using the chi-squared and the Mann-Whitney test. Patient and graft survival were analyzed by the Kaplan-Meier method and compared using the log-rank test.
Group A presented younger donors (55 vs 67 years) and recipients (53 vs 58 years), a higher number of donors with previous history of hypertension (92% vs 43%) and higher pre-harvesting creatinine values (1.2 vs 0.9 mg/dL). Post-transplant graft function did not present statistical differences. Five-year patient and graft survivals results were similar (Fig. 1).
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