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Volume 10 Supplement 1

de Senectute: Age and Health Forum

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The protective role of physical activity in different pathologies

The protective role of physical activity in different pathologies has been shown in numerous scientific studies on the general public and especially among older adults [1].

Physical activity has been shown to be effective in reducing the onset of several chronic pathologies, such as cardiovascular diseases, hypertension [2], diabetes, osteoporosis, obesity [3]. and neoplastic diseases, also it helps to diminish depression and anxiety by maintaining a balanced mood.

Exercise activates the metabolic system in order to supply energy, in a trained organism it increases the use of glucose from part of the muscle which increases or diminishes the onset of hyperglycemia, typical of diabetes [4].

Lipid metabolism is favorably influenced by the decrease of the lipoprotein at low density LDL by increasing the HDL [5].

An exercise that burns out 4-7 Kcal/minute reduces cardiovascular mortality rate in men and women, no matter the age group. Increasing the intensity of muscle activity, the risk of mortality rate in cardiovascular diseases tend to progressively diminish [6].

Regular physical activity has also significantly been shown to decrease the risk of colon and breast cancer [7].

The mechanical stimulus produced by physical activity promotes bone remodelling. In particular, physical activity transfers stimulus to the bone in two ways: directly to the body’s weight on the skeleton, and indirectly through muscle activity [8].


  1. Warburton DE, et al: Health benefit of physician activity: the evidence. CMAJ. 2006, 174: 801-9.

    Article  PubMed  PubMed Central  Google Scholar 

  2. Fagard RH, Cornelissen VA: Effect of exercise on blood pressure control in hypertensive patients. Eur J Cardiovasc Prev Rehabil. 2007, 14: 12-7. 10.1097/HJR.0b013e3280128bbb.

    Article  PubMed  Google Scholar 

  3. Jakicic JM, Otto AD: Physical activity considerations for the treatment and prevention of obesity. Am J Clin Nutr. 2005, 82: 226S-229S.

    PubMed  CAS  Google Scholar 

  4. Jeon C, et al: Physical activity of moderate intensity and risk of type 2 diabetes. Diabetes Care. 2007, 30: 744-52. 10.2337/dc06-1842.

    Article  PubMed  Google Scholar 

  5. Kodama S, et al: Effect of aerobic exercise training on serum levels of high-density lipoprotein cholesterol: a meta-analysis. Arch Intern Med. 2007, 167: 999-1008. 10.1001/archinte.167.10.999.

    Article  PubMed  CAS  Google Scholar 

  6. Noda H, et al: Walking and sports participation and mortality from coronary heart disease and stroke. J Am Coll Cardiol. 2005, 46: 1761-7. 10.1016/j.jacc.2005.07.038.

    Article  PubMed  Google Scholar 

  7. McTiernan A, et al: Recreational physical activity and the risk of breast cancer in postmenopausal women. JAMA. 2003, 290: 1331-10.1001/jama.290.10.1331.

    Article  PubMed  CAS  Google Scholar 

  8. Borer KT, Wuorinen E, Ku K, Burant C: Walking intensity for postmenopausal bone mineral preservation and accrual. Bone. 2007, 41 (4): 713-21. 10.1016/j.bone.2007.06.009.

    Article  PubMed  Google Scholar 

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Open Access This article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution 2.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Gradilone, A. The protective role of physical activity in different pathologies. BMC Geriatr 10 (Suppl 1), L36 (2010).

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