Volume 10 Supplement 1
Nodular thyroid disease in the erderly
- A Belfiore1
© Belfiore; licensee BioMed Central Ltd. 2010
Published: 19 May 2010
The occurrence of thyroid nodules increases with age . In geographical areas with a normal iodine intake, approximately 10% of the population develops a palpable thyroid nodule. This proportion increases in areas with insufficient iodine intake. Non-palpable thyroid nodules are usually diagnosed by a neck echography carried out for various reasons and are 5-10 folds more common than palpable nodules.
When evaluating a thyroid nodule, we must be aware that two conditions require particular attention: a) the possibility of a “hot” (hyperfunctioning) nodule, which can induce thyrotoxicosis; b) the possibility of a malignant nodule.
Both these pathological conditions increase with age [2, 3]. In particular, elderly patients often show a multinodular goiter, where both hyperfunctioning nodules and hypofunctioning nodules suspicious for malignancy may coexist. When FT3 is high and/or TSH is suppressed a hyperfunctioning nodule should be suspected. In order to confirm this diagnosis the patient should carry out a thyroid scintigram. In the case that both FT3 and TSH are in the normal range, the nodule should be regarded as non-functioning. In this case a thyroid scintigram is not useful whereas a fine needle aspiration (FNAB) is the diagnostic procedure of choice .
Both hyperfunctioning and malignant thyroid nodules are more common in elderly patients. Notably, hyperthyroidism is a more serious condition in the elderly than in the young because of an increased risk of cardiac dysfunction. Moreover, thyroid cancer behaves more aggressively in elderly patients. In these patients thyroid cancer is usually less differentiated and lacks the ability to concentrate iodine. Therefore, thyroid cancer metastases cannot be treated with radioiodine.
In the case of a hyperfunctioning nodule the therapy of choice is a thyroid lobectomy. In contrast, in the case of a multinodular goiter or of a malignant nodule, a total thyrodectomy is required.
- Mazzaferri EL: Management of a solitary thyroid nodule. N Engl J Med. 1993, 328: 553-559. 10.1056/NEJM199302253280807.PubMedView ArticleGoogle Scholar
- Belfiore A, Sava L, Runello F, Tomaselli L, Vigneri R: Solitary autonomously functioning thyroid nodules and iodine deficiency. J Clin Endocrinol Metab. 1983, 56: 283-287. 10.1210/jcem-56-2-283.PubMedView ArticleGoogle Scholar
- Belfiore A, La Rosa GL, La Porta GA, Giuffrida D, Milazzo G, Lupo L, Regalbuto C, Vigneri R: Cancer risk in patients with cold thyroid nodules: relevance of iodine intake, sex, age, and multinodularity. Am J Med. 1992, 93: 363-369. 10.1016/0002-9343(92)90164-7.PubMedView ArticleGoogle Scholar
- Belfiore A, La Rosa GL: Fine-needle aspiration biopsy of the thyroid. Endocrinol Metab Clin North Am. 2001, 30: 361-400. 10.1016/S0889-8529(05)70191-2.PubMedView ArticleGoogle Scholar
This article is published under license to BioMed Central Ltd.