Thromboembolic tendency (TE) in IBD (inflammatory bowel disease) patients
© Canero et al; licensee BioMed Central Ltd. 2010
Published: 19 May 2010
Materials and methods
We performed a 3 year study on 71 patients with IBD, evaluating hypercoaugulability, and then we compared the results with 71 patients non IBD group control.
We also investigated patients of both groups concerning TE events occurred already.
In IBD group we found out that 16 patients (22.5%) had a history of TE versus >1% of group control.
19 of them, already had knowledge of their previous hypercoaugulating condition.
48 (67%) had increased markers value versus less then 6% detected in group control.
In IBD group 43% ,20% and 4.2% had respectively 1, 1-3 or > 3 markers higher levels then normal range.
Among the markers investigated, we detected increased levels of plated in 33%, homocysteine in 26.7%, d-dimero 25.3%, c3 in 15.4%, apcr in 5.6%.
From our study we detected a higher incidence of TE events, and hypercoaugulating status in IBD group. In our previous investigations, plated, homocysteine, d-dimero, c3, and apcr, seemed to be the TE markers with higher sensibility.
It seems reasonable, according our experience, to propose a new TE risk score index for IBD patients:
low, mild and high risk respectively for patients with 1 , 1-3 and >3 markers with higher serum levels then normal range.
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