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BMC Geriatrics

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Volume 10 Supplement 1

de Senectute: Age and Health Forum

Open Access

Prognostic value of PCR, IL-6 and IL-10 serum levels in determining postoperative complications after geriatric surgery in diabetic patients

  • B Cudia1,
  • C R Balistreri2,
  • G Guercio1,
  • F Bavetta1,
  • M Mangiapane1,
  • E Bonafede1,
  • C LoPiccolo1,
  • F Frazzetta1 and
  • G Diana1
BMC Geriatrics201010(Suppl 1):A5

https://doi.org/10.1186/1471-2318-10-S1-A5

Published: 19 May 2010

Background

The onset of postoperative septic complications has been associated to serum levels of interleukin (IL) IL-6 and IL-10. [1, 2]. We have extrapolated a diabetic group from a previous study to evaluate pre and postoperative profiles of some inflammatory markers (IL-6 , IL-10 and CRP). We related the data obtained to the onset of postoperative complications. Diabetic patients have been selected because of their high rate of post-operative complications, especially surgical wound infection.

Materials and methods

We evaluated 15 patients, 6 males and 9 females, aged ≥ 70 (range 70-83). The preoperative criterium for inclusion was non urgent major abdominal surgery and a diabetes diagnosis, the exclusion criteria were: urgent abdominal surgery, therapy with steroid and/or immunosuppressor drugs during the 30 days before admission. For each patient we collected three peripheral venous blood samples, at preoperative time 0 (t0), and then at first (t1) and seventh (t2) postoperative day. Cytokine evaluation was obtained by the ELISA method with the “sandwich” tecnique. Among the latter we considered: surgical wound infection; urinary tract infection; respiratory infection / respiratory failure; SIRS and/or sepsis; anastomotic leakage; peritonitis.

Results

We observed 4 complications corresponding to 26,6% of all evaluated patients (Table 1).

Table 1

POSTOPERATIVE COMPLICATIONS

N

Anastomotic leakege

1

Respiratory failure

1

Urinary tract infection

1

Respiratory infection

1

All subjects at (t1) showed an elevation of IL-6 levels, more consistent in the complicated ones (140.25 ± 100.89 pg/ml vs 91.54 ± 31.75 pg/ml) (Figure 1). IL-1 showed lower basic levels (t0) in complicated patients (14.54 ± 12.64 pg/ml vs 12 ± 10.70 pg/ml) and also in (t1) (26,36 ± 31,43 pg/ml vs 14,75 ± 7,41 pg/ml ) (Figure 2). The CRP values didn’t differ at any time between the two groups (Figure 3).

Figure 1

Figure 2

Figure 3

Conclusions

In the group of elderly diabetic patients observed, so as in the general population, according to published data [1], IL-6 and IL-10 may be referred as prognostic markers with regard to postoperative complication. It would be moreover useful to identify a cut-off value to select the subjects with a higher postoperative risk.

Authors’ Affiliations

(1)
U.O.C. Chirurgia Generale e Geriatrica, AOU Policlinico di Palermo
(2)
Department of Pathobiology and Biomedical Methodologies, University of Palermo

References

  1. Mokart D, Merlin M, Sannini A, et al: Procalcitonin, interleukin 6 and systemic inflammatory response syndrome (SIRS): early markers of postoperative sepsis after major surgery. Br J Anesth. 2005, 94 (6): 767-73. 10.1093/bja/aei143.View ArticleGoogle Scholar
  2. Maggio M, Guralnik JM, Ferrucci L, Longo DL: Interleukin-6 in aging and chronic disease: a magnificent pathway. J.gerontology (MS). 2006, 61: 575-584.Google Scholar

Copyright

© Cudia et al; licensee BioMed Central Ltd. 2010

This article is published under license to BioMed Central Ltd.

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