Prognostic value of PCR, IL-6 and IL-10 serum levels in determining postoperative complications after geriatric surgery in diabetic patients
© Cudia et al; licensee BioMed Central Ltd. 2010
Published: 19 May 2010
The onset of postoperative septic complications has been associated to serum levels of interleukin (IL) IL-6 and IL-10. [1, 2]. We have extrapolated a diabetic group from a previous study to evaluate pre and postoperative profiles of some inflammatory markers (IL-6 , IL-10 and CRP). We related the data obtained to the onset of postoperative complications. Diabetic patients have been selected because of their high rate of post-operative complications, especially surgical wound infection.
Materials and methods
We evaluated 15 patients, 6 males and 9 females, aged ≥ 70 (range 70-83). The preoperative criterium for inclusion was non urgent major abdominal surgery and a diabetes diagnosis, the exclusion criteria were: urgent abdominal surgery, therapy with steroid and/or immunosuppressor drugs during the 30 days before admission. For each patient we collected three peripheral venous blood samples, at preoperative time 0 (t0), and then at first (t1) and seventh (t2) postoperative day. Cytokine evaluation was obtained by the ELISA method with the “sandwich” tecnique. Among the latter we considered: surgical wound infection; urinary tract infection; respiratory infection / respiratory failure; SIRS and/or sepsis; anastomotic leakage; peritonitis.
Urinary tract infection
In the group of elderly diabetic patients observed, so as in the general population, according to published data , IL-6 and IL-10 may be referred as prognostic markers with regard to postoperative complication. It would be moreover useful to identify a cut-off value to select the subjects with a higher postoperative risk.
- Mokart D, Merlin M, Sannini A, et al: Procalcitonin, interleukin 6 and systemic inflammatory response syndrome (SIRS): early markers of postoperative sepsis after major surgery. Br J Anesth. 2005, 94 (6): 767-73. 10.1093/bja/aei143.View ArticleGoogle Scholar
- Maggio M, Guralnik JM, Ferrucci L, Longo DL: Interleukin-6 in aging and chronic disease: a magnificent pathway. J.gerontology (MS). 2006, 61: 575-584.Google Scholar
This article is published under license to BioMed Central Ltd.