Results of surgical and percutaneous ablative therapy for hepatocellular carcinoma in elderly patients
© Selvaggi et al; licensee BioMed Central Ltd. 2010
Published: 19 May 2010
Liver resection is a curative treatment for hepatocellular carcinoma (HCC) . Its role for the elderly remains undefined. In addition to surgery, percutaneous procedures have recently been proposed [2, 3]. The choice of surgical and non-surgical therapy closely depends on the liver functional reserve and pre-existing co-morbidities.
Materials and methods
A retrospective analysis of a geriatric population (≥ 65 years) with HCC was proposed (July 2000-September 2009). Morbidity, survival, and recurrence rate were evaluated.
The role of liver resection for HCC is debated in the elderly. This is related to the short life expectancy and improvement of percutaneous procedures. These seem to guarantee similar overall survival compared to surgery. Unfortunately, this was not demonstrated from our data. With the improvement of surgical and anesthesia support, mortality has been significantly reduced. We performed liver resections in selected cases and our experience confirms the surgical benefits in elderly population.
- Nuzzo G, Giuliante F, Gauzolino R, Vellone M, Ardito F, Giovannini I: Liver resections for hepatocellular carcinoma in chronic liver disease: experience in an Italian centre. Eur J Surg Oncol. 2007, 33: 1014-1018.PubMedView ArticleGoogle Scholar
- Lupo L, Panzera P, Giannelli G, Memeo M, Gentile A, Memeo V: Single hepatocellular carcinoma ranging from 3 to 5 cm: radiofrequency ablation or resection?. HBP. 2007, 9: 429-434.Google Scholar
- Belghiti J, Kianmanesh R: Surgical treatment of hepatocellular carcinoma. HPB. 2005, 7: 42-49.PubMedPubMed CentralView ArticleGoogle Scholar
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