A rare case of extraovarian primary peritoneal carcinoma in a 72 year-old woman
© Moccia et al; licensee BioMed Central Ltd. 2010
Published: 19 May 2010
Extraovarian Primary Peritoneal Carcinoma (EOPPC) was first described by Swerdlow in 1959 . Basically, EOPPC is a malignancy that spreads widely inside the peritoneal cavity involving mostly the omentum with minimal or no ovarian involvement. Most of the EOPPC cases reported have been of serous histology; histopathological, immunohistochemical, and clinical similarities have been observed between EOPPC and Epithelial Ovarian Cancer (EOC).
Materials and methods
The morphological features such as serous papillary carcinoma and the presence of many psammoma bodies and the immunohistochemical highly positive for CA 125 (Figure 3) have determined the diagnosis of EOPPC.
As the EOPPC is mullerian malignancy as the epithelial layer of ovary and the peritoneum share a common embryological origin and it undergoes a chemotherapeutic treatment as ovarian primary carcinoma. Paclitaxel with platinum compounds have been introduced into chemotherapeutic regimens for EOC. In the first report describing the use of the combination of paclitaxel (135mg/m2) and cisplatin (50 to 75 mg/m2), given for six cycles in four EOPPC patients, Menzin et al  showed a complete surgical response in one patient and a partial surgical response in the others. Patients with EOPPC should be reported separately from those with ovarian carcinoma but should be treated in a similar fashion.
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