Dedifferentiated liposarcomas: evaluation of the prognostic and therapeutic factors in the elderly patient
© Amodeo et al; licensee BioMed Central Ltd. 2010
Published: 19 May 2010
Liposarcomas (LPS) are rare tumors accounting approximately for 19% of adult soft-tissue tumors . The most recent classification of the WHO divides liposarcomas into 3 main clinicopatological and genetic subtypes: myxoid/round cells liposarcoma, well differentiated / dedifferentiated liposarcoma and pleomorphic liposarcoma . The importance of a total macroscopical resection to perform an oncologically correct operation is well known, so that it is often necessary to remove one or more adjoining organs with the purpose of reducing the risk of local secondary recurrences .
Materials and methods
We decide to perform surgery. The neoplasia is in continuity with the tail of the pancreas, so a distal pancreasectomy and splenectomy is performed. Definitive histological examination: dedifferentiated liposarcoma of high degree.
After surgical resection of the primitive liposarcoma, factors determining the probability of recurrence and survival are: histological type, the impossibility to perform a complete resection, the removal of adjoining organs and the advanced age .
In retroperitoneal and abdominal lesions surgical treatment remains the most important therapy because of the evident lack of benefit of chemotherapy and the impossibility to administer doses suitable of radiation without serious damag to the healthy tissues. Studies are in progress for the revaluation of intraoperative radiotherapy (IORT) and of preoperative chemotherapy.
- Gutierrez JC, Perez EA, Franceschi D, Moffat FL, Livingstone AS, Koniaris LG: Outcomes for soft-tissue sarcoma in 8249 cases from a large state cancer registry. Journal of surgical research. 2007, 141: 105-114. 10.1016/j.jss.2007.02.026.PubMedView ArticleGoogle Scholar
- Mussi C, Collini P, Miceli R, Barisella M, Mariani L, Fiore M, Casali PG, Gronchi A: The prognostic impact of dedifferentiation in retroperitoneal liposarcoma. Cancer. 2008, 113: 1657-65;7. 10.1002/cncr.23774.PubMedView ArticleGoogle Scholar
- Singer Doglietto GB, Tortorelli AP, Papa V, Rosa F, Bossola M, Prete F, Covino M, Pacelli F: Giant retroperitoneal sarcomas: a single institution experience. World J Surg. 2007, 31: 1047-1054. 10.1007/s00268-006-0433-6.View ArticleGoogle Scholar
- S, Antonescu CR, Riedel E, et al: Histological subtype and margin of resection predict pattern of recurrence and survival for retroperitoneal liposarcoma. Ann Surg. 2003, 238 (1): 358-370.Google Scholar
This article is published under license to BioMed Central Ltd.