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Table 2 Demographic, clinical data, HGS, muscle mass metrics and sarcopenia prevalence rates in male and female AD patients

From: Sarcopenia in subjects with Alzheimer’s disease: prevalence and comparison of agreement between EGWSOP1, EGWSOP2, and FNIH criteria

 

AD male

(n = 61)

Mean ± SD

AD female

(n = 84)

Mean ± SD

t(143) or χ2

p-values

Demographic and clinical data

    

    Age, y

70.57 ± 9.09

72.19 ± 7.68

−1.16

0.249

    BMI

25.46 ± 3.02

26.18 ± 4.51

−1.03

0.280

    MMSE

16.57 ± 5.37

17.17 ± 5.42

−0.65

0.515

Muscle Strength and Muscle Mass

    

    HGS

21.36 ± 7.26

14.64 ± 5.74

37.39a

<0.0001

    SMI

10.77 ± 1.27

8.97 ± 1.36

67.83a

<0.0001

    SM

30.96 ± 4.84

21.96 ± 4.11

152.22a

<0.0001

    ASM

23.03 ± 3.48

17.60 ± 2.79

136.95a

<0.0001

    ASM/height2

8.01 ± 0.87

7.20 ± 0.90

48.51a

<0.0001

    MQI

0.70 ± 0.23

0.70 ± 0.32

0.01a

0.907

Sarcopenia diagnostic algorithms

    

    EWGSOP1, Low muscle mass (%)

36 (59%)

1 (1.2%)

62.17

<0.0001

    EWGSOP1, Low muscle strength (%)

54 (88.5%)

65 (77.4%)

2.98

0.084

    EWGSOP1, Sarcopenia (%)

34 (55.7%)

0

61.16

<0.0001

    EWGSOP2, Low muscle strength (%)

47 (77%)

48 (57.1%)

6.20

<0.005

    EWGSOP2, Low muscle mass (%)

5 (8.2%)

1 (1.2%)

4.37

<0.05

    EWGSOP2, Sarcopenia (%)

5 (8.2%)

0

7.13

<0.01

    FNIH, Low muscle strength (%)

43 (70.5%)

48 (57.1%)

2.69

0.101

    FNIH, Low muscle mass (%)

13 (21.3%)

5 (6%)

7.67

<0.01

    FNIH, Sarcopenia (%)

12 (19.7%)

2 (2.4%)

12.11

<0.001

  1. AD Alzheimer disease, BMI Body Mass Index, HGS hand grip strength, SMI Skeletal Muscle Index, SM Skeletal Muscle Mass, ASM Appendicular Skeletal Muscle Mass, MQI Muscle Quality Index, EWGSOP1 European Working Group on Sarcopenia in Older People criteria of 2010, EWGSOP2 European Working Group on Sarcopenia in Older People criteria of 2018, FNIH Foundation for the National Institutes of Health criteria
  2. aStudent’s t-test corrected for age and BMI