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Table 1 Demographic, clinical data, HGS, muscle mass metrics and sarcopenia prevalence rates in AD patients and controls

From: Sarcopenia in subjects with Alzheimer’s disease: prevalence and comparison of agreement between EGWSOP1, EGWSOP2, and FNIH criteria

 

AD

(n = 145)

Mean ± SD

Controls

(n = 51)

Mean ± SD

t(194) or χ2

p-values

Demographic and clinical data

    Male/Female

61/84

20/31

0.13

0.722

    Age, y

71.51 ± 8.31

64.71 ± 11.02

4.60

<0.0001

    BMI

25.88 ± 3.96

27.65 ± 4.75

−2.61

<0.01

    MMSE

16.92 ± 5.39

27.51 ± 1.89

−13.72

<0.0001

Muscle Strength and Muscle Mass

    HGS

17.47 ± 7.22

21.78 ± 8.30

13.93a

<0.0005

    SMI

9.73 ± 1.59

9.98 ± 1.75

0.01a

0.938

    SM

26.38 ± 5.31

25.75 ± 6.27

0.17a

0.683

    ASM

20.85 ± 4.08

19.88 ± 4.10

0.07a

0.790

    ASM/height2

7.54 ± 0.97

7.88 ± 1.28

0.00a

0.956

    MQI

0.70 ± 0.29

0.84 ± 0.28

11.33a

<0.001

Sarcopenia diagnostic algorithms

    EWGSOP1, Low muscle mass (%)

37 (25.5%)

9 (17.6%)

1.30

0.254

    EWGSOP1, Low muscle strength (%)

119 (82.1%)

29 (56.9%)

12.96

<0.0005

    EWGSOP1, Sarcopenia (%)

34 (23.4%)

6 (11.8%)

3.17

0.075

    EWGSOP2, Low muscle strength (%)

95 (65.5%)

18 (35.3%)

14.12

<0.0005

    EWGSOP2, Low muscle mass (%)

6 (4.1%)

3 (5.9%)

0.26

0.609

    EWGSOP2, Sarcopenia (%)

5 (3.4%)

1 (2.0%)

0.28

0.596

    FNIH, Low muscle strength (%)

91 (62.8%)

18 (35.3%)

11.53

<0.001

    FNIH, Low muscle mass (%)

18 (12.4%)

10 (19.6%)

1.59

0.207

    FNIH, Sarcopenia (%)

14 (9.7%)

3 (5.9%)

0.68

0.410

  1. AD Alzheimer disease, BMI Body Mass Index, HGS: hand grip strength, SMI Skeletal Muscle Index, SM Skeletal Muscle Mass, ASM Appendicular Skeletal Muscle Mass, MQI Muscle Quality Index, EWGSOP1 European Working Group on Sarcopenia in Older People criteria of 2010, EWGSOP2 European Working Group on Sarcopenia in Older People criteria of 2018, FNIH Foundation for the National Institutes of Health criteria
  2. aStudent’s t-test corrected for age, sex and BMI