Dyslipidemia is associated with sarcopenia of the elderly: a meta-analysis

Bi, Bingqing; Dong, Xinying; Yan, Meilin; Zhao, Zhuo; Liu, Ruitong; Li, Shugang; Wu, Hao

doi:10.1186/s12877-024-04761-4

BMC Geriatrics

Table 1 Characteristics of studies

From: Dyslipidemia is associated with sarcopenia of the elderly: a meta-analysis

No.	Research	Country	Age/years	The indicators this research include	Diagnostic criteria of sarcopenia	Diagnostic criteria of dyslipidemia
1	S. J. Baek [4]	Korea	≧ 65	2,3,4,5,6,7,9	Asia criteria1^a	Criteria5
2	Yuan Zhang [5]	China	≧ 60	1,8	Asia criteria1^a	Critertia1
3	Jiaojiao Li [6]	China	≧ 60	2,3,4,5,9	Asia criteria1^a	Criteria3
4	Hanyi Zou [9]	China	≧ 60	1,8	Asia criteria1^a	Criteria2
5	Peipei Han [10]	China	≧ 60	1,8	Asia criteria1^a	Criteria4
6	Yu Wang [11]	China	≧ 60	2,3,4,5,9	Asia criteria2^d	Criteria3
7	Rui Cheng [12]	China	≧ 60	1,8	Asia criteria1^a	Criteria4
8	Lijuan Wang [13]	China	≧ 60	2,3,4,5	Asia criteria1^a	Criteria4
9	Hee-Sook Lim [14]	America	≧ 60	1,8	Europena criteria^b	Criteria6
10	Yourui Xu [15]	China	≧ 60	2,5	Asia criteria1^a	Criteria2
11	Ruirui Hao [16]	China	≧ 60	2,3,4,9	Asia criteria3^e	Criteria3
12	Nan Wang [17]	China	≧ 60	2,3,4,5,6,9	Asia criteria1^a	Criteria2
13	Xuelian Zhang [18]	China	≧ 60	2,3,4,5	Asia criteria1^a	Criteria3
14	Syed Shahid Habib [19]	Syrian Arab Republic	≧ 60	2,4,5	Syrian Arab Republic’s criteria^c	Criteria6
15	Yanping Du [20]	China	≧ 65	2,3,4,5,7,9	Asia criteria1^a	Criteria1
16	Ana Coto Montes [21]	Korea	≧ 60	1,2,3,4,5,7,8,9,	Asia criteria1^a	Criteria6
17	Seong-Joon Park [22]	Korea	≧ 60	4,5	Asia criteria1^a	Criteria7
18	Jun-Hyuk Lee [23]	Korea	≧ 60	2,3,4,5	Asia criteria1^a	Criteria8
19	K Sanada [24]	Japan	≧ 60	4,5,6	Asia criteria1^a	Ctiteria6
20	Qifan Zhou [25]	China	20–60	2,9	Asia criteria1^a	Criteria2

Indicators:1:Overall OR,2:Overall TC MD,3:Overall LDL-C MD,4:Overall HDL-C MD,5:Overall TG MD,6:Overall TG/HDL-C, 7:Subgroup analysis of gender, 8:Subgroup analysis of area, 9:Subgroup analysis of age
^a(i) skeletal muscle mass index (BIA) of the limbs: <7.0 kg/m2 for men < 5.7 kg/m2 for women; (ii) assessment of physical function: 6-meter stride < 1.0 m/s or SPPB score ≤ 9 or standing test ≥ 12 s; (iii) grip strength: <28 kg for men and < 18 kg for women; if ① and ② or③ were satisfied, the diagnosis of sarcopenia was made;
^bMuscle mass decreased by dual energy X-ray absorptiometry (DXA)was divided by body weight and calculated as a percentage. When the calculated value was less than 1 standard deviation (SD), it was classified as sarcopenia.
^cAuthors analyzed appendicular lean mass (ALM) and hand grip strength test (HGS). Total and percent lean mass and TLM/ ht2 were calculated. ALM is the sum of arm and leg lean mass, and ALM/ht2 was also calculated. The sarcopenia was defined when the ALM/ht2 was less than 7.46.
^dSkeletal muscle mass index (SMI) = Skeletal muscle mass/body weight ×100%, Sarcopenia is defined as a condition where the standard deviation is 2 times lower than that of the young control group (18–39 years old) of the same sex
^eThe calculation of skeletal muscle index (SMI) based on imaging to determine the presence of sarcopenia is calculated by dividing the total muscle area by the square of height. The threshold for diagnosing sarcopenia is less than 42.6 cm2/m2 for males and less than 30.6 cm2/m2 for females
Critertia1:TC ≥ 6.2 mmol/L、HDL-C ≥ 4.1 mmol/L、HDL-C ≤ 1.0 mmol/L、TG ≥ 2.3 mmol/L or use lipid-lowering drugs
Criteria2: TC ≥ 6.2 mmol/L、HDL-C ≥ 4.1 mmol/L、HDL-C ≤ 1.0 mmol/L、TG ≥ 2.3 mmol/L
Criteria3:LDL-C ≥ 3.37mmol/L, HDL-C<1.04mmol/L, TC ≥ 5.18mmol/L,TG ≥ 1.7mmol/L
Criteria4:TG ≥ 2.26 mmol/L, TC ≥ 6.22mmol/L, LDL -C ≥ 4.14 mmol/L, HDL-C ≤ 1.04mmol/L
Criteria5:TG > 400 mg/dL, HDL-C ≤ 160 mg/dL, TG/HDL-C>4
Criteria6: TG > 150 mg/dL, HDL-C < 40 mg/dL
Criteria7:TG > 150 mg/dL,HDL-C < 40 mg/dL for males or < 50 mg/dL for females or use of dyslipidemia medication
Criteria8: HDL-C < 40 mg/dL

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