Causal associations between leisure sedentary behaviors and sleep status with frailty: insight from Mendelian randomization study

Table 3 Multivariable MR results for the causal association of watching television, sleep duration, and daytime napping with FI

Exposure	Adjustment	Method	Beta	95%CI	P value
Watching television	BMI, cigarettes per day, and drinks per week	MVMR-IVW	0.27	0.20–0.35	1.19e-12^*
		MVMR-Egger	0.27	0.19–0.34	2.44e-12^*
Sleep duration	BMI, cigarettes per day, and drinks per week	MVMR-IVW	-0.17	-0.27– -0.09	1.55e-04^*
		MVMR-Egger	-0.17	-0.26– -0.08	2.17e-04^*
Daytime napping	BMI, cigarettes per day, and drinks per week	MVMR-IVW	0.23	0.10–0.36	4.89e-04^*
		MVMR-Egger	0.20	0.02–0.38	0.03^*

Abbreviation: FI, frailty index; MVMR, multivariable Mendelian randomization; IVW, inverse-variance weighted; CI, confidence interval; BMI, body mass index
^*P value < 0.05

ISSN: 1471-2318