Causal associations between leisure sedentary behaviors and sleep status with frailty: insight from Mendelian randomization study

Table 1 Univariable MR results for the causal associations between leisure sedentary behaviors, sleep status and the FI

Exposure	No of SNPs	F -statistics	IVW		MR-Egger		Weighted median		MR-PRESSO
Exposure	No of SNPs	F -statistics	Beta (95%CI)	P value	Beta (95%CI)	P value	Beta (95%CI)	P value	Beta (95%CI)	P value
Leisure sedentary behavior
Watching television	138	40.78	0.26 (0.21–0.31)	3.98e-25^*	0.39 (0.15–0.63)	1.96e-03^*	0.23 (0.17–0.29)	7.22e-13^*	0.26 (0.21–0.31)	6.45e-19^*
Computer usage	42	38.97	0.01 (-0.11–0.14)	0.82	-0.30 (-1.09–0.49)	0.46	0.03 (-0.10–0.16)	0.63	0.01 (-0.11–0.14)	0.82
Driving	4	38.25	0.36 (0.03–0.70)	0.03	2.59 (0.65–4.52)	0.12	0.21 (-0.11–0.53)	0.20	0.36 (0.03–0.70)	0.13
Sleep status
Sleep duration	62	47.86	-0.18 (-0.26 – -0.10)	6.04e-06^*	0.01 (-0.29–0.30)	0.97	-0.19 (-0.28– -0.10)	6.63e-05^*	-0.18 (-0.26– -0.10)	2.85e-05^*
Snoring	32	171.77	0.04 (-0.01–0.08)	0.10	-0.13 (-0.37–0.10)	0.27	0.03 (-0.03–0.08)	0.35	0.04 (-0.01–0.08)	0.11
Daytime napping	94	15.14	0.29 (0.18–0.41)	2.68e-07^*	0.33 (-0.09–0.75)	0.13	0.28 (0.15–0.41)	1.80e-05^*	0.29 (0.18–0.41)	1.48e-06^*

Abbreviation: FI frailty index; MR, Mendelian randomization; IVW, inverse-variance-weighted; MR-PRESSO, Mendelian Randomization Pleiotropy RESidual Sum and Outlier; CI, confidence interval
^*P value < 0.05

ISSN: 1471-2318