Effects of dexmedetomidine combined with etomidate on postoperative cognitive function in older patients undergoing total intravenous anaesthesia: a randomized, double-blind, controlled trial

Table 8 The plasma concentration of S-100β at different time points in four groups

Time points	EN₁ group( pg/ml) n=34	ED₁ group( pg/ml) n=31	EN₂ group( pg/ml) n=32	ED₂ group( pg/ml) n=35	F values	P values
t₀	66.5±7.3	66.8±9.0	66.9±0.6	66.8±7.5	0.0217	0.995
t₁	121.0±17.4*^$	108.6±12.9*^#$	143.6±13.9*^#	125.5±15.6*^$&	28.391	0.000
t₂	105.6±11.9*^$	83.1±7.9*^#$	117.4±13.1*^#	107.0±18.0*^$&	37.2856	0.000
t₃	69.0±8^$	67.3±8.7^$	94.8±10.8*^#	81.3±16.7*^#$&	39.438	0.000
t₄	67.5±6.7	67.0±9.0	70.7±8.1	67.5±6.8	1.574	0.198
t₅	66.9±7.5	66.8±9.4	67.3±7.6	66.6±7.1	0.036	0.991
F values	178.513	94.065	286.857	130.356	—	—
P values	0.000	0.000	0.000	0.000	—	—

S-100β S-100 calcium-binding protein B, EN₁ Etomidate-remifentanil with duration of surgery less than 60min, ED₁ Etomidate-remifentanil and dexmedetomidine with duration of surgery less than 60min, EN₂ Etomidate-remifentanil with duration of surgery more than 60min, ED₂ Etomidate-remifentanil and dexmedetomidine with duration of surgery more than 60min. t₀ 30 minutes before anesthesia, t₁ 3h after surgery, t₂ 8h after surgery, t₃ 24h after surgery, t₄ 48h hours after surgery and t₅ 72h after surgery. * p < 0.05 vs.t₀, ^# p < 0.05 vs.EN₁, ^$ p < 0.05 vs.EN₂ and ^&p < 0.05 vs.ED₁

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