Effects of dexmedetomidine combined with etomidate on postoperative cognitive function in older patients undergoing total intravenous anaesthesia: a randomized, double-blind, controlled trial

Table 6 The State-Trait Anxiety Inventory scores at different time points in four groups

Indexes	Groups	n	t₀	t₁	t₂	t₃	t₄	t₅	F values	P values
S-AI	EN1	34	39.7±2.2	47.5±3.0*	46.2±2.8*	40.7±2.7^$	39.7±2.9	39.3±2.2	64.896	0.000
	ED1	31	40.2±3.0	44.5±2.5*^#$	42.5±2.3*^#$	40.1±1.8^$	39.7±2.4	39.8±3.0	18.597	0.000
	EN2	32	39.8±2.8	48.3±2.7*	46.6±2.5*	43.3±2.4*^#	39.8±2.5	40.1±2.3	66.797	0.000
	ED2	35	39.8±2.7	45.1±2.7*^#$	43.1±2.4*^#$	41.0±2.7^$	39.8±2.4	40.0±2.6	21.721	0.000
	F values	0.206		14.260	21,320	10.689	0.023	0.727	——
	P values	0.891		0.000	0.000	0.000	0.995	0.537	——
T-AI	EN1	34	39.9±2.7	48.4±2.4*	47.1±3.1*	40.5±2.5	39.47±2.3	39.9±3.0	77.193	0.000
	ED1	31	39.6±3.0	45.6±3.7*^#$	42.2±2.9*^#$	40.7±3.2	39.8±2.8	39.5±3.1	17.807	0.000
	EN2	32	39.7±3.3	48.8±2.6*	47.6±2.4*	42.5±2.9*^#	40.0±2.7	39.9±3.2	60.479	0.000
	ED2	35	39.4±3.0	46.5±3.8*^#$	42.7±3.3*^#$	41.6±2.9*	39.6±3.1	39.8±3.3	22.990	0.000
	F values	0.276		7.420	28.984	3.131	0289	0.297	——
	P values	0.842		0.000	0.000	0.028	0833	0.827	——

EN₁ Etomidate-remifentanil with duration of surgery less than 60min, ED₁ Etomidate-remifentanil and dexmedetomidine with duration of surgery less than 60min, EN₂ Etomidate-remifentanil with duration of surgery more than 60min, ED₂ Etomidate-remifentanil and dexmedetomidine with duration of surgery more than 60min. t₀ 30 minutes before anesthesia, t₁ 3h after surgery, t₂ 8h after surgery, t₃ 24h after surgery, t₄ 48h hours after surgery and t₅ 72h after surgery. *p < 0.05 vs.t₀, ^# p < 0.05 vs.EN₁ and ^$ p < 0.05 vs.EN₂

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