Table 3 Combined associations of 25(OH)D deficiency and high hs-CRP with mortality risk

Over all (n = 3072)

Vitamin D sufficiency + normal hs-CRP

672

185

Ref.

—

60

Ref.

—

125

Ref.

—

Vitamin D deficiency alone

1756

799

1.45 (1.16 ~ 1.62)

< 0.001

255

1.76 (1.35 ~ 2.38)

0.001

544

1.47 (1.28 ~ 1.68)

< 0.001

High hs-CRP alone

142

65

1.51 (1.14 ~ 2.03)

< 0.001

26

1.90 (1.19 ~ 2.77)

0.004

39

1.50 (1.04 ~ 2.17)

0.031

Vitamin D deficiency + high hs-CRP

502

272

2.18 (1.73 ~ 2.56)

< 0.001

107

2.30 (1.64 ~ 3.21)

< 0.001

165

2.19 (1.79 ~ 2.49)

< 0.001

RERI (95%CI)

0.22 (0.04 ~ 0.41)

−0.36 (−1.26 ~ 0.52)

0.21 (0.06 ~ 0.37)

Men (n = 1397)

Vitamin D sufficiency + normal hs-CRP

435

104

Ref.

—

32

Ref.

—

72

Ref.

—

Vitamin D deficiency alone

651

232

1.43 (1.06 ~ 1.70)

0.001

77

1.75 (1.15 ~ 2.71)

0.004

155

1.41 (1.06 ~ 1.79)

0.023

High hs-CRP alone

89

43

1.62 (1.11 ~ 2.29)

0.003

17

2.65 (1.38 ~ 4.27)

0.002

26

1.29 (0.82 ~ 1.96)

0.412

Vitamin D deficiency + high hs-CRP

222

119

2.25 (1.72 ~ 2.99)

< 0.001

45

2.91 (1.79 ~ 4.49)

< 0.001

74

2.51 (1.64 ~ 3.39)

< 0.001

RERI (95%CI)

0.19 (0.03 ~ 0.35)

−0.51 (−1.52 ~ 0.50)

0.80 (0.18 ~ 1.42)

Women (n = 1675)

Vitamin D sufficiency + normal hs-CRP

237

81

Ref.

—

28

Ref.

—

53

Ref.

—

Vitamin D deficiency alone

1105

567

1.56 (1.23 ~ 1.97)

< 0.001

178

1.48 (0.97 ~ 2.21)

0.086

389

1.68 (1.17 ~ 2.41)

0.003

High hs-CRP alone

53

22

1.23 (0.81 ~ 1.95)

0.465

9

1.17 (0.66 ~ 2.53)

0.732

13

1.34 (0.84 ~ 2.21)

0.494

Vitamin D deficiency + high hs-CRP

280

153

1.87 (1.35 ~ 2.16)

0.005

62

1.84 (1.15 ~ 2.90)

0.021

91

1.99 (1.48 ~ 2.57)

0.008

RERI (95%CI)

0.07 (−0.23 ~ 0.38)

0.18 (−0.06 ~ 0.43)

−0.02 (−0.12 ~ 0.07)