Fig. 5

Association between serum inflammatory biomarkers and monocyte-specific genes. The heatmap shows β regression coefficients between serum inflammatory biomarkers and PBMC gene expression for the top 30 monocyte-specific genes, as derived from a CIBERSORT analysis. The models were adjusted for age and BMI; to aid comparison, we scaled both inflammatory biomarkers and genes to a standard normal distribution (with mean zero and standard deviation one). Rows and columns are clustered by hierarchical clustering (Euclidean distance). Abbreviations: CRP, C-reactive protein; IGF1, insulin-like growth factor-1; IL6, interleukin 6; Gp-acetyls, glycoprotein acetyls. * P < 0.05, ** P < 0.01, *** P < 0.001