Fig. 3

Association between frailty index score and PBMC gene expression. The volcano plot shows the β regression coefficient (x-axis) and–log P-value (y-axis) for each gene transcript (total number of 11 925 transcripts). Horizontal lines correspond to (from the bottom) P-value thresholds 0.05, 0.01, and 0.001; the labels display the counts and proportions of the total number of transcripts within each P-value category. The annotated genes are a random subset among genes with P < 0.01. Abbreviations: FI, frailty index; PBMC, peripheral blood mononuclear cells