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Table 4 Predictive validity estimates at different cutoff scores and base rates of cognitive impairment

From: Diagnostic accuracy of BASIC-Q for detection of cognitive impairment in a primary care setting – a cross-validation study

 

Base rate 10%

Base rate 25%

Base rate 50%

Cutoff

PPV (95% CI)

NPV (95% CI)

PPV (95% CI)

NPV (95% CI)

PPV (95% CI)

NPV (95% CI)

14/15

0.30 (0.18–0.44)

0.95 (0.91–0.97)

0.57 (0.45–0.69)

0.85 (0.80–0.90)

0.80 (0.71–0.87)

0.66 (0.59–0.73)

15/16

0.28 (0.18–0.40)

0.96 (0.93–0.98)

0.55 (0.44–0.66)

0.89 (0.83–0.93)

0.78 (0.70–0.85)

0.72 (0.64–0.85)

16/17*

0.23 (0.15–0.33)

0.97 (0.94–0.99)

0.48 (0.38–0.57)

0.91 (0.86–0.95)

0.73 (0.66–0.80)

0.78 (0.70–0.85)

17/18

0.20 (0.13–0.28)

0.99 (0.96-1.00)

0.43 (0.35–0.51)

0.95 (0.90–0.98)

0.69 (0.62–0.76)

0.87 (0.79–0.93)

18/19

0.15 (0.10–0.20)

0.97 (0.91–0.99)

0.34 (0.27–0.41)

0.99 (0.94-1.00)

0.60 (0.54–0.67)

0.94 (0.85–0.98)

  1. Abbreviations: CI, confidence interval; PPV, Positive predictive validity; NPV, negative predictive validity
  2. * Optimal cutoff score