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Table 3 Proportion of association of per SD of body mass index with trajectories of cognitive function scores mediated by physical activity

From: Association between obesity, physical activity, and cognitive decline in Chinese middle and old-aged adults: a mediation analysis

Effect

Model 1

 

Model 2

 

Model 3

 

Estimate (95% CI)

P

 

Estimate (95% CI)

P

 

Estimate (95% CI)

P

Physical activity (n = 3,172)

Total Effect (TE), Odds Ratio

0.81(0.73,0.89)

< 0.001

 

0.81(0.73,0.89)

< 0.001

 

0.82(0.73,0.90)

< 0.001

Natural Direct Effect (NDE), Odds Ratio

0.81(0.73,0.89)

< 0.001

 

0.81(0.73,0.89)

< 0.001

 

0.82(0.73,0.90)

< 0.001

Natural Indirect Effect (NIE), Odds Ratio

1.00(1.00,1.00)

0.958

 

1.00(1.00,1.00)

0.958

 

1.00(1.00,1.00)

0.834

Percentage Mediated (PM)

-0.03(-1.33,1.26)

0.958

 

-0.03(-1.25,1.18)

0.958

 

0.14(-1.21,1.50)

0.834

Vigorous physical activity (n = 3,172)

        

Total Effect (TE), Odds Ratio

0.81(0.73,0.89)

< 0.001

 

0.80(0.72,0.88)

< 0.001

 

0.81(0.72,0.89)

< 0.001

Natural Direct Effect (NDE), Odds Ratio

0.83(0.75,0.91)

< 0.001

 

0.81(0.73,0.89)

< 0.001

 

0.82(0.73,0.90)

< 0.001

Natural Indirect Effect (NIE), Odds Ratio

0.98(0.96,0.99)

0.000

 

0.98(0.97,0.99)

0.002

 

0.99(0.97,1.00)

0.012

Percentage Mediated (PM)

10.74(3.26,18.22)

0.005

 

8.06(1.43,14.69)

0.017

 

5.94(0.29,11.60)

0.040

Moderately energetic physical activity (n = 3,169)

Total Effect (TE), Odds Ratio

0.81(0.73,0.89)

< 0.001

 

0.81(0.73,0.89)

< 0.001

 

0.82(0.73,0.90)

< 0.001

Natural Direct Effect (NDE), Odds Ratio

0.81(0.73,0.89)

< 0.001

 

0.81(0.73,0.89)

< 0.001

 

0.82(0.73,0.90)

< 0.001

Natural Indirect Effect (NIE), Odds Ratio

1.00(1.00,1.00)

0.898

 

1.00(1.00,1.00)

0.764

 

1.00(1.00,1.00)

0.742

Percentage Mediated (PM)

-0.09(-1.54,1.36)

0.898

 

-0.27(-2.01,1.48)

0.764

 

-0.25(-1.72,1.23)

0.743

Mildly energetic physical activity (n = 3,165)

Total Effect (TE), Odds Ratio

0.81(0.73,0.89)

< 0.001

 

0.81(0.73,0.89)

< 0.001

 

0.82(0.73,0.90)

< 0.001

Natural Direct Effect (NDE), Odds Ratio

0.81(0.73,0.89)

< 0.001

 

0.81(0.73,0.89)

< 0.001

 

0.82(0.74,0.90)

< 0.001

Natural Indirect Effect (NIE), Odds Ratio

1.00(0.99,1.00)

0.455

 

1.00(0.99,1.00)

0.464

 

1.00(0.99,1.00)

0.365

Percentage Mediated (PM)

0.66(-1.10,2.43)

0.461

 

0.68(-1.16,2.52)

0.470

 

0.99(-1.21,3.19)

0.378

  1. Abbreviations: SD indicates standard deviation
  2. *Model 1 was adjusted for age and gender; Model 2 was further adjusted for the interaction of BMI per SD and Physical activity; Model 3 was further adjusted for marital status, medical history (CVD, diabetes, hypertension, dyslipidemia, and chronic kidney disease), and history of medication use (CVD medications, hypertension medications, diabetes medications, and lipid-lowering therapy)
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BMC Geriatrics

ISSN: 1471-2318

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