Skip to main content

Table 2 Distribution of patients’ data on drug use

From: Clinical pharmacist-led assessment and management of anticholinergic burden and fall risk in geriatric patients

Variables

Control (n = 301)

Intervention (n = 300)

Total (n = 601)

p

Drugs, n (%)

Metoprolol

157 (52.2)

74 (24.6)

331 (55.1)

0.150

Furosemide

84 (27.9)

60 (20.0)

144 (24.0)

0.023*

Warfarin

27 (9.0)

23 (7.7)

50 (8.3)

0.667

Colchicin

19 (6.3)

26 (8.7)

45 (7.5)

0.346

Digoxin

24 (8.0)

18 (6.0)

42 (7.0)

0.430

Isosorbide mononitrate

13 (4.3)

16 (5.3)

29 (4.8)

0.697

Trazodone

14 (4.7)

15 (5.0)

29 (4.8)

0.993

Desloratadine

10 (3.3)

10 (3.3)

20 (3.3)

1.000

Cetirizine

8 (2.7)

9 (3.0)

17 (2.8)

0.994

Fesoterodine§

8 (2.7)

7 (2.3)

15 (2.5)

1.000

Tolterodine§

10 (3.3)

5 (1.7)

15 (2.5)

0.299

Solifenacin§

5 (1.7)

9 (3.0)

14 (2.3)

0.414

Trospium§

9 (3.0)

4 (1.3)

13 (2.2)

0.262

Paroxetine§

6 (2.0)

6 (2.0)

12 (2.0)

1.000

Risperidone

6 (2.0)

5 (1.7)

11 (1.8)

1.000

Venlafaxine

5 (1.7)

4 (1.3)

9 (1.5)

1.000

Levocetirizine

4 (1.3)

4 (1.3)

8 (1.3)

0.996

Nifedipine

3 (1.0)

3 (1.0)

6 (1.0)

1.000

Olanzapine§

3 (1.0)

2 (0.7)

5 (0.8)

1.000

Carbamazepine

3 (1.0)

2 (0.7)

5 (0.8)

1.000

Amitriptyline§

3 (1.0)

2 (0.7)

5 (0.8)

1.000

Hydroxyzine§

1 (0.3)

3 (1.0)

4 (0.7)

0.373

Alprazolam

1 (0.3)

3 (1.0)

4 (0.7)

0.373

Captopril

2 (0.7)

2 (0.7)

4 (0.7)

1.000

Dimenhydrinate§

1 (0.3)

2 (0.7)

3 (0.5)

0.624

Trifluoperazine§

2 (0.7)

1 (0.3)

3 (0.5)

1.000

Amantadine

-

2 (0.7)

2 (0.3)

0.950

Doxylamine§

1 (0.3)

1 (0.3)

2 (0.3)

1.000

Haloperidol

2 (0.7)

-

2 (0.3)

0.499

Darifenacin§

-

1 (0.3)

1 (0.2)

0.499

Oxybutynin§

1 (0.3)

-

1 (0.2)

1.000

Clozapine§

1 (0.3)

-

1 (0.2)

1.000

Loratadine

1 (0.3)

-

1 (0.2)

1.000

Diazepam

1 (0.3)

-

1 (0.2)

1.000

Number of anticholinergic drugs, mean (SD)

Median (range)

1.45 (0.72)

1 (1–5)

1.41 (0.73)

1 (1–6)

1.43 (0.72)

1 (1–6)

0.991

Total number of daily drugs, mean (SD)

Median (range)

7.70 (3.18)

7 (1–21)

7.61 (3.40)

7 (1–17)

7.65 (3.39)

7 (1–21)

0.966

Polypharmacy (≥ 5), n (%)

254 (84.4)

241 (80.3)

495 (82.4)

0.193

Number of anticholinergic drugs to total number of daily drugs ratio, mean (SD)

Median (range)

0.22 (0.13)

0.18 (0.06-1)

0.22 (0.45)

0.17 (0.06-1)

0.22 (0.14)

0.18 (0.06-1)

0.983

Pre-intervention ACBS, mean (SD)

Median (range)

1.78 (1.17)

1 (1–9)

1.72 (1.17)

1 (1–10)

1.75 (1.17)

1 (1–10)

0.918

Pre-intervention ACBS (high risk), n (%)

66 (21.9)

62 (20.7)

128 (21.3)

0.706

Post-intervention ACBS, mean (SD)

Median (range)

-

1.64 (1.08)

1 (0–10)

1.71 (1.13)

1 (0–10)

0.813

Post-intervention ACBS (high risk), n (%)

-

60 (20.0)

126 (21.0)

0.562

  1. SD: standard deviation, ACBS: Anticholinergic Cognitive Burden Scale
  2. According to the Anticholinergic Cognitive Burden Scale; 1 point,2 points, §3 points, *p < 0.05