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Table 4 Sensitive analysis for the association of anemia with vitamin B12 status

From: Vitamin B12 is associated negatively with anemia in older Chinese adults with a low dietary diversity level: evidence from the Healthy Ageing and Biomarkers Cohort Study (HABCS)

Variables

Unadjusted

Basic modela

Final Modelb

OR(95%CI)

P

OR(95%CI)

P

OR(95%CI)

P

All anemia (N=291)

      

Low B12 (<277pg/mL)

1.0 (ref.)

 

1.0 (ref.)

 

1.0 (ref.)

 

Medium B12 2 (277–375pg/mL)

0.69 (0.54–0.87)

0.002

0.73 (0.57–0.93)

0.011

0.76 (0.58–0.99)

0.039

High B12 (>375pg/mL)

0.53 (0.43–0.65)

<0.001

0.62 (0.5–0.76)

<0.001

0.63 (0.50–0.79)

<0.001

Low DDS group (N=404 )

      

Low B12 (< 277pg/mL)

1.0 (ref.)

 

1.0 (ref.)

 

1.0 (ref.)

 

Medium B12 (277–375pg/mL)

0.54 (0.39–0.74)

<0.001

0.55 (0.–0.77)

0.001

0.56 (0.39–0.79)

0.001

High B12 (>375pg/mL)

0.48 (0.36–0.64)

<0.001

0.53 (0.39–0.71)

<0.001

0.53 (0.39–0.72)

<0.001

DDS ≤ 3 (N=271)

      

Low B12 (< 277pg/mL)

1.0 (ref.)

 

1.0 (ref.)

 

1.0 (ref.)

 

Medium B12 (277–375pg/mL)

0.57 (0.39–0.84)

0.0048

0.6 (0.40–0.90)

0.014

0.62 (0.39–0.97)

0.038

High B12  (>375pg/mL)

0.47 (0.33–0.67)

<0.0001

0.53 (0.36–0.77)

0.001

0.55 (0.36–0.84)

0.005

DDS=4 (N=133)

      

Low B12 (< 277pg/mL)

1.0 (ref.)

 

1.0 (ref.)

 

1.0 (ref.)

 

Medium B12 (277–375pg/mL)

0.5 (0.28–0.88)

0.0157

0.52 (0.29–0.94)

0.030

0.45 (0.23–0.88)

0.019

High B12 (>375pg/mL)

0.52 (0.32–0.83)

0.0065

0.57 (0.35–0.94)

0.026

0.42 (0.24–0.74)

0.003

High DDS group (N=287)

      

Low B12 (< 277pg/mL)

1.0 (ref.)

 

1.0 (ref.)

 

1.0 (ref.)

 

Medium B12 (277–375pg/mL)

0.95 (0.66–1.35)

0.766

1.04 (0.72–1.51)

0.837

1.16 (0.78–1.73)

0.463

High B12 (>375pg/mL)

0.62 (0.46–0.85)

0.003

0.78 (0.56–1.07)

0.123

0.80 (0.57–1.14)

0.215

DDS=5 (N=134)

      

Low B12 (< 277pg/mL)

1.0 (ref.)

 

1.0 (ref.)

 

1.0 (ref.)

 

Medium B12 (277–375pg/mL)

1.20 (0.71–2.04)

0.4934

1.38 (0.79–2.4)

0.263

1.32 (0.71–2.43)

0.381

High B12 (>375pg/mL)

0.97 (0.61–1.53)

0.8909

1.13 (0.70–1.83)

0.616

1.11 (0.65–1.88)

0.710

DDS≥6 (N=153)

      

Low B12 (< 277pg/mL)

1.0 (ref.)

 

1.0 (ref.)

 

1.0 (ref.)

 

Medium B12 (277–375pg/mL)

0.77 (0.48–1.25)

0.2956

0.83 (0.50–1.37)

0.461

1.10 (0.63–1.94)

0.733

High B12 (>375pg/mL)

0.46 (0.30–0.69)

0.0002

0.57 (0.37–0.89)

0.014

0.61 (0.37–1.00)

0.050

All severe anemia (N=250)

      

Low B12 (< 277pg/mL)

1.0 (ref.)

 

1.0 (ref.)

 

1.0 (ref.)

 

Medium B12 (277–375pg/mL)

0.55 (0.38–0.82)

0.003

0.57 (0.39–0.86)

0.007

0.63 (0.41–0.96)

0.033

High B12 (>375pg/mL)

0.68 (0.51–0.91)

0.011

0.80 (0.59–1.09)

0.158

0.81 (0.58–1.14)

0.226

Severe anemia  with low DDS group (N=157)

      

Low B12 (< 277pg/mL)

1.0 (ref.)

 

1.0 (ref.)

 

1.0 (ref.)

 

Medium B12 (277–375pg/mL)

0.43 (0.26–0.72)

0.001

0.44 (0.26–0.74)

0.002

0.47 (0.27–0.83)

0.009

High B12 (>375pg/mL)

0.63 (0.43–0.94)

0.024

0.71 (0.47–1.06)

0.092

0.70 (0.46–1.08)

0.110

Severe anemia with high DDS group (N=93)

      

Low B12 (< 277pg/mL)

1.0 (ref.)

 

1.0 (ref.)

 

1.0 (ref.)

 

Medium B12 (277–375pg/mL)

0.94 (0.52–1.70)

0.830

1.05 (0.57–1.94)

0.880

1.21 (0.82–2.33)

0.560

High B12 (>375pg/mL)

1.03 (0.64–1.64)

0.919

1.36 (0.82–2.23)

0.231

1.39 (0.82–2.37)

0.224

  1. aBasic model, adjusted for age, gender
  2. bFinal model, adjusted for age, gender, race, education levels, current marital status, physic activity habits, smoking habits, tea drinking habits, BMI
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