Table 1 Demographics and clinical characteristics of patients with and without SCH in older patients with MDD
|  | Total | Patients without SCH (0.27 ≤ TSH ≤ 4.2) | Patients with SCH (TSH > 4.2) | F or χ2 | P value |
|---|---|---|---|---|---|
Older MDD Patients (%) | 266 | 94 (35.3%) | 172 (64.7%) | Â | Â |
Gender | Â | Â | Â | 0.336 | 0.562 |
male, N (%) | 68(25.6%) | 26(27.7%) | 42(24.4%) | Â | Â |
female, N (%) | 198(74.4%) | 68(72.3%) | 130(75.6%) | Â | Â |
Age (years) | 54(51, 57) | 54(51, 57.25) | 54(51, 56) | 0.516 | 0.473 |
Age of onset (years) | 54(51, 56) | 54(51, 57.25) | 53.5(51, 56) | 1.467 | 0.226 |
Disease course (month) | 6(4, 12) | 4(2.375, 8.25) | 8(5, 13) | 24.720 | 0.000** |
Years of education (years) | 9(9, 12) | 9(9, 12) | 9(9, 12) | 0.542 | 0.462 |
Marital status | Â | Â | Â | 7.342 | 0.007* |
Married | 257(96.6%) | 87(92.6%) | 170(98.8%) | Â | Â |
Unmarried | 9(3.4%) | 7(7.4%) | 2(1.2%) | Â | Â |
HAMD | 31(29, 32) | 29(27, 31) | 32(29, 33) | 34.204 | 0.000** |
HAMA | 21(18.75, 23) | 21(18, 23) | 21(19, 23) | 1.988 | 0.159 |
Positive total score | 7(7, 9) | 7(7, 7) | 7(7, 10) | 9.183 | 0.002* |
TSH | 5.399 ± 2.721 | 2.576 ± 1.084 | 6.942 ± 2.015 | 380.660 | 0.000** |
A-TG | 22.19 (14.313, 59.689) | 20.175 (13.718, 27.708) | 23.305(15.285, 115.393) | 10.035 | 0.002* |
A-TPO | 17.67 (11.995, 39.115) | 14.885(10.035, 26.635) | 22.165(12.51, 56.808) | 13.066 | 0.000** |
FT3 | 4.829 ± 0.750 | 4.766 ± 0.672 | 4.863 ± 0.789 | 1.030 | 0.311 |
FT4 | 16.23(14.29, 18.658) | 16.86(14.41, 19.975) | 16.07(14.29, 18.288) | 3.309 | 0.069 |
HDL-C | 1.19(0.98, 1.3925) | 1.265(1.11, 1.493) | 1.13(0.91, 1.3) | 17.280 | 0.000** |
LDL-C | 3.062 ± 0.830 | 2.604 ± 0.624 | 3.313 ± 0.822 | 85.555 | 0.000** |
TC | 5.390 ± 1.074 | 4.672 ± 0.807 | 5.782 ± 0.998 | 53.104 | 0.000** |
TG | 1.99(1.45, 2.76) | 1.81(1.47, 2.458) | 2.155(1.42, 2.885) | 4.936 | 0.026 |
FPG | 5.4(4.9575, 5.87) | 5.07(4.76, 5.473) | 5.57(5.143, 5.98) | 32.222 | 0.000** |
BMI | 24.19 (23.2, 25.48) | 23.7(22.978, 25.358) | 24.375(23.443, 26.021) | 6.949 | 0.008* |
Systolic pressure | 128(122, 134) | 126(119.75, 130) | 130(124, 135) | 14.642 | 0.000** |
Diastolic pressure | 78(72, 85) | 78(70, 85.25) | 78(72, 85) | 0.334 | 0.563 |
CGI | Â | Â | Â | 11.293 | 0.004* |
5 | 80(30.1%) | 35(37.2%) | 45(26.2%) | Â | Â |
6 | 104(39.1%) | 42(44.7%) | 62(36.0%) | Â | Â |
7 | 82(30.8%) | 17(18.1%) | 65(37.8%) | Â | Â |
Severe anxiety | Â | Â | Â | 1.240 | 0.266 |
NO | 223(83.8%) | 82(87.2%) | 141(82.0%) | Â | Â |
YES | 43(16.2%) | 12(12.8%) | 31(18.0%) | Â | Â |
Attempted suicide | Â | Â | Â | 5.660 | 0.017* |
NO | 201(75.6%) | 79(84%) | 122(70.9%) | Â | Â |
YES | 65(24.4%) | 15(16%) | 50(29.1%) | Â | Â |
Psychotic symptoms | Â | Â | Â | 2.901 | 0.089 |
NO | 224(84.2%) | 84(89.4%) | 140(81.4%) | Â | Â |
YES | 42(15.8%) | 10(10.6%) | 32(18.6%) | Â | Â |