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Table 2 Multivariable Cox proportional hazard models for risk of MACE

From: Thiazide-associated hyponatremia increases the risk of major adverse cardiovascular events among elderly Taiwanese patients

 

Crude HR

(95%CI)

P-value

Adjusted HR

(95%CI)

P-value

TAH

1.56(1.26‒1.92)

< 0.001

1.29(1.01‒1.65)

0.039

Age

1.04(1.02‒1.05)

< 0.001

1.03(1.01‒1.05)

< 0.001

Sex, male

1.11(0.91‒1.36)

0.311

  

CCIS

1.13(1.06‒1.20)

< 0.001

1.08(1.01‒1.16)

0.028

DM

1.13(0.91‒1.40)

0.284

  

Medication

    

 ACEI

1.15(0.83‒1.59)

0.408

  

 ARB

0.71(0.58‒0.88)

0.002

0.77(0.62‒0.96)

0.020

 CCB

0.87(0.71‒1.06)

0.153

  

 α-blockers

1.04(0.76‒1.42)

0.814

  

 β-blockers

1.02(0.81‒1.27)

0.883

  

 Furosemide

1.68(1.33‒2.14)

< 0.001

1.42(1.10‒1.84)

0.008

 Indapamide

0.21(0.07‒0.64)

0.006

0.21(0.07‒0.66)

0.007

 Spironolactone

0.67(0.33‒1.36)

0.266

  

 Amiloride

0.62(0.33‒1.15)

0.128

  

 NSAIDs

1.20(0.97‒1.47)

0.084

  

 TCA

0.87(0.46‒1.61)

0.648

  

 Diazepam

1.05(0.71‒1.55)

0.806

  
  1. *Adjusted HRs were calculated after controlling for age, CCIS, DM, medications.
  2. **Abbreviations: HR, hazard ratio; CI, confidence interval; TAH, thiazide-associated hyponatremia; CCIS, Charlson Comorbidity Index score; DM, diabetes mellitus; ACEI, angiotensin converting enzyme inhibitors; ARB, angiotensin II receptor blocker; CCB, calcium channel blocker; NSAIDs, non-steroidal anti-inflammatory drugs; TCA, tricyclic antidepressant.