Fig. 1

MRI, tau PET, and perfusion SPECT images. Brain magnetic resonance imaging revealed bilateral frontotemporal lobar atrophy on T2/fluid-attenuated inversion recovery (FLAIR) (A). Tau positron emission tomography (PET) with Florzolotau (¹⁸F) demonstrated remarkable uptake of the ligand around the brainstem, subthalamic nucleus, basal ganglia, and bilateral subcortical frontal lobe (B). ¹²³I-N-isopropyl-p-iodoamphetamine (¹²³I-IMP) single-photon emission computed tomography (SPECT) showed reduced cerebral blood flow in the bilateral frontal lobe and basal ganglia (C-1). Easy Z-score imaging system (eZIS) analysis of ¹²³I-IMP SPECT imaging also revealed significantly decreased regional cerebral blood flow (rCBF) in bilateral frontal areas, including the anterior operculum (C-2). SUVR, standardized uptake value ratio; RT, right; LT, left; LAT, lateral; SUP, superior; INF, inferior; ANT, anterior; POST, posterior; MED, medial