Table 2 Clinical characteristics

Alzheimer’s Disease

Diagnosis lies between two conditions (2 cases), Diagnostic uncertainty (4 cases), Mixed aetiology (1 case), Uncertain aetiology (2 cases), reason not stated (10 cases)

8 (47.1)

11 (21.6)

FTD Syndromes

- Behavioural FTD (bvFTD)

Diagnosis lies between two conditions (3 cases), Uncertain aetiology (1 case), reason not stated (7 cases)

0

11 (21.6)

- Primary Progressive Aphasia (PPA)

Diagnosis lies between two conditions (1 case), Diagnostic uncertainty (2 cases), Uncertain aetiology (3 cases), reason not stated (1 case)

1 (5.9)

6 (11.8)

- Logopenic Aphasia

Diagnosis lies between two conditions (1 case)

1 (5.9)

0

Progressive Supranuclear Palsy

Diagnosis lies between two conditions (2 cases), Diagnostic uncertainty (3 cases), reason not stated (2 cases)

2 (11.8)

5 (9.8)

Corticobasal Degeneration

Diagnostic uncertainty (1 case), reason not stated (2 cases)

1 (5.9)

2 (3.9)

Mixed Dementia

Diagnosis lies between two conditions (3 cases), Diagnostic uncertainty (3 cases), Mixed aetiology (2 cases), reason not stated (1 case)

2 (11.8)

7 (13.7)

Posterior Cortical Atrophy

Diagnosis lies between two conditions (1 case), reason not stated (2 cases)

1 (5.9)

2 (3.9)

Lewy Body Dementia

Diagnostic uncertainty (1 case), Uncertain aetiology (1 case)

0

2 (3.9)

Vascular Dementia

Diagnostic uncertainty (1 case)

0

1 (2.0)

Unspecified Dementia

Diagnostic uncertainty (2 case), reason not stated (1 case), Uncertain aetiology (1 case)

1 (5.9)

3 (5.9)

Multiple System Atrophy

Uncertain aetiology (1 case)

0

1 (2.0)

Other clinical characteristics

Recruited

(n = 17) (n, %)

Not recruited

(n = 51)

P value

Symptoms* (pre-65 + study referral)

- Progressive deterioration

15 (88.2)

49 (96.1)

0.202

Deficits

◦ Memory

17 (100.0)

45 (88.2)

0.334

◦ Language

11 (64.7)

38 (74.5)

0.298

◦ Fluency

13 (76.5)

39 (76.5)

0.032

◦ Behaviour

10 (58.8)

31 (60.8)

0.672

◦ Attention

10 (58.8)

28 (54.9)

0.232

◦ Visuospatial

14 (82.4)

31 (60.8)

0.221

Pre-existing comorbidities*

- Diabetes

1 (5.9)

6 (11.8)

0.787

- Hypertension

5 (29.4)

16 (31.4)

0.826

Alcohol history*

5 (29.4)

15 (29.4)

0.984

Number of consultations

- Mean number of visits (95%CI, SD)

3.9 (2.3–5.5, 3.2)

3.3 (2.7–3.96, 2.2)

0.257 [t(22df)= -0.664]

- Mean number of days between last visit and invitation to the study (95%CI, SD)

58.5 (-3.6–120.6, 120.8)

117 (56.5–177.6, 215.6)

0.085 [t(50df) = 1.391]