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Table 3 Algorithmic diagnosis including Clinical Dementia Rating (CDR) scores and neuropsychological test-based diagnosis of normal, amnestic and non-amnestic Mild Cognitive Impairment (aMCI; naMCI) and early (eMCI) and late MCI (LMCI)

From: Study protocol for “In-vehicle sensors to detect changes in cognition of older drivers”

CDR Sum of Boxes

Neuropsychological Diagnosis (NpDx)

Normal

aMCI

naMCI

Dementia

0

Normal

PreMCI –NP

PreMCI-NP

Consensus Conference

0.5–2.0

PreMCI Clinical

eMCI

eMCI

Consensus Conference

2.5–4.0

PreMCI Clinical

eMCI

eMCI

LMCI

4.5+

Consensus Conference

Dementia

Dementia

Dementia

  1. [Rule 1: CDR-sb score > 4.0 indicates dementia diagnosis (except when NpDx is Normal)]
  2. [Rule 2: CDR-sb score of 2.5 to 4.0 indicates an LMCI diagnosis (except when NpDx is Normal)]
  3. [Rule 3: CDR-sb score of 0.5 to 2.0 indicates an eMCI diagnosis (except when NpDx is Normal)]
  4. [Rule 4: Pre-MCI is diagnosed when CDR-sb 0.5–4.0 and NpDx is normal, or CDR-sb = 0 and NpDx = aMCI or naMCI]
  5. CDR-sb = CDR sum of boxes, aMCI = Amnestic MCI, naMCI = Non-amnestic MCI, LMCI = Late MCI, eMCI = Early MCI