BMC Geriatrics

Table 5 Mixed effects modelling of factors associated with mini-mental state examination scores

From: Dementia subtypes, cognitive decline and survival among older adults attending a memory clinic in Cape Town, South Africa: a retrospective study

Model 1 with TTE				Model 2 with Age at Onset				Model 3 with Age at Diagnosis
	Coeff	95% CI	p-value		Coeff	95% CI	p-value		Coeff	95% CI	p-value
TTE	-0.37	-1.19—0.45	0.375	Age at Onset	0.80	-0.62—2.22	0.270	Age at Diagnosis	0.91	-0.67—2.49	0.260
TTE²	0.02	-0.03—0.06	0.482	Age at Onset²	-0.005	-0.01—0.05	0.339	Age at diagnosis²	-0.01	-0.02—0.05	0.299
Sex				Sex				Sex
*Male*	-0.48	-1.87—0.91	0.500	*Male*	-0.15	-1.52—1.22	0.826	*Male*	-0.19	-1.55—1.81	0.789
Years of Education				Years of Education				Years of Education
8 to 12 years	1.38	-0.14—2.90	0.075	8 to 12 years	1.34	-0.15—2.84	0.078	8 to 12 years	1.45	-0.04—2.95	0.057
≥ 13 years	4.07	1.90—6.25	< 0.0001	≥ 13 years	4.15	2.00—6.31	< 0.0001	≥ 13 years	4.27	2.11—6.43	< 0.0001
Comorbidity Score				Comorbidity Score				Comorbidity Score
3 to 4	0.95	-0.51—2.41	0.201	3 to 4	0.83	-0.62—2.28	0.259	3 to 4	0.95	-0.50—2.39	0.200
≥ 5	1.63	-0.04—3.31	0.056	≥ 5	1.44	-0.23—3.10	0.091	≥ 5	1.50	-0.13—3.14	0.072
Dementia Subtype				Dementia Subtype				Dementia Subtype
VND	2.37	0.43—4.31	0.017	VND	2.81	0.88—4.74	0.004	VND	2.82	0.87—4.77	0.005
DLB/PDD	-0.16	-2.64—2.32	0.901	DLB/PDD	0.05	-2.34—2.44	0.968	DLB/PDD	0.07	-2.34—2.49	0.951
FTD	0.25	-4.80—5.30	0.923	FTD	0.93	-4.08—5.94	0.716	FTD	0.39	-4.63—5.42	0.878

Abbreviations: TTE Time to Event = from onset of symptoms to death or end of study period, Coeff Coefficient, CI confidence interval, Age at Onset Age at onset of symptoms of dementia, Age at Diagnosis Age when diagnosis of dementia was established, TTE² TTE-squared variables, Age at Onset² age at onset-squared variables, Age at diagnosis² age at diagnosis-squared variables, VND Major Vascular Neurocognitive Disorder, DLB Dementia with Lewy bodies, PDD Parkinson’s disease dementia, FTD Fronto-temporal dementia

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ISSN: 1471-2318

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