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Table 1 Characteristics of study population according to sarcopenia

From: Plasma acylcarnitine in elderly Taiwanese: as biomarkers of possible sarcopenia and sarcopenia

 

Con

LPF

S

SS

P value

Parameter

n = 57

n = 104

n = 63

n = 65

LPF vs. Con

S vs. Con

SS vs. Con

Age

75.9 ± 7.5

81.9 ± 6.8

82.5 ± 5.8

86.3 ± 4.2

0.0000

0.0000

0.0000

Male (%)

46%

24%

51%

62%

0.0118

0.5707

0.0782

height (cm)

161.2 ± 8.2

154.6 ± 6.6

158.2 ± 8.2

158.7 ± 8.9

0.0000

0.0471

0.1126

weight (kg)

61.1 ± 11.6

60.3 ± 8.8

55.2 ± 10.2

54.5 ± 10.5

0.6437

0.0038

0.0013

BMI (kg/m2)

23.4 ± 3.2

25.2 ± 3.1

21.8 ± 2.8

21.5 ± 3.0

0.0008

0.0040

0.0012

ASMI (kg/m2)

6.4 ± 0.9

6.4 ± 0.7

5.7 ± 0.8

5.6 ± 0.8

0.9968

0.0000

0.0000

HGS (kg)

26.3 ± 6.3

15.4 ± 5.5

18.2 ± 6.7

16.4 ± 5.7

0.0000

0.0000

0.0000

GS(m/sec)

1.3 ± 0.3

0.9 ± 0.3

1.2 ± 0.2

0.7 ± 0.2

0.0000

0.0062

0.0000

glucose (mg/dL)

97.4 ± 20.2

99.1 ± 15.4

97.7 ± 20.7

103.6 ± 36.5

0.5892

0.9347

0.2445

HbA1c (%)

5.8 ± 0.5

5.9 ± 0.6

5.8 ± 0.6

6.0 ± 1.0

0.4072

0.9269

0.2863

LDL (mg/dL)

111.5 ± 34.4

106.3 ± 31.1

106.7 ± 28.1

99.5 ± 25.4

0.3383

0.4021

0.0330

HDL (mg/dL)

53.7 ± 12.0

53.2 ± 12.2

54.9 ± 14.1

52.8 ± 13.1

0.8077

0.6377

0.6792

Chol (mg/dL)

185.0 ± 38.7

182.7 ± 37.3

180.0 ± 34.6

172.5 ± 31.7

0.7108

0.4517

0.0517

TG(mg/dL)

102.5 ± 58.7

109.1 ± 54.1

86.9 ± 34.3

95.8 ± 60.9

0.4723

0.0838

0.5394

Albumin (g/dL)

4.4 ± 0.3

4.3 ± 0.3

4.3 ± 0.2

4.3 ± 0.2

0.6934

0.5767

0.0565

T-protein (g/dL)

7.0 ± 0.4

6.9 ± 0.4

7.0 ± 0.4

7.0 ± 0.4

0.5447

0.8991

0.6439

T-bilirubin (mg/dL)

0.7 ± 0.3

0.7 ± 0.3

0.8 ± 0.4

0.8 ± 0.4

0.8765

0.4802

0.5600

BUN (mg/dL)

15.2 ± 3.9

17.8 ± 9.1

17.2 ± 6.4

21.9 ± 11.3

0.0097

0.0355

0.0000

Creatinine (mg/dL)

0.8 ± 0.2

0.9 ± 0.9

0.9 ± 0.5

1.1 ± 0.7

0.3428

0.0769

0.0069

Uric acid (mg/dL)

5.4 ± 1.3

5.7 ± 1.6

5.7 ± 1.6

6.1 ± 1.6

0.2446

0.3592

0.0155

AST/GOT (U/L)

29.7 ± 19.4

26.7 ± 9.7

28.7 ± 10.0

30.6 ± 40.3

0.2818

0.7187

0.8776

ALT/GPT (U/L)

23.5 ± 21.8

19.7 ± 16.4

19.9 ± 12.9

23.7 ± 55.6

0.2593

0.2798

0.9786

ALKP (U/L)

67.7 ± 24.2

68.1 ± 19.2

61.7 ± 16.6

65.5 ± 22.2

0.9255

0.1159

0.5969

TSH (uIU/ml)

2.4 ± 1.7

2.6 ± 2.3

2.4 ± 1.9

2.8 ± 2.2

0.6411

0.9895

0.3386

T4 (ug/dL)

8.6 ± 1.5

8.0 ± 1.7

8.2 ± 1.6

8.2 ± 1.7

0.0303

0.1056

0.1085

Cortisol (ug/dL)

13.6 ± 4.9

13.8 ± 4.7

13.5 ± 4.6

16.1 ± 4.8

0.7915

0.9336

0.0053

Vit B12 (pg/ml)

754.1 ± 538.5

735.3 ± 503.6

694.5 ± 375.3

890.6 ± 702.3

0.8270

0.4904

0.2294

WBC (103/ul)

5.3 ± 1.5

5.4 ± 1.5

5.5 ± 1.4

5.7 ± 1.4

0.7553

0.4920

0.2367

RBC (106/ul)

4.4 ± 0.4

4.3 ± 0.5

4.3 ± 0.4

4.2 ± 0.5

0.1865

0.1047

0.0092

Hemoglobin g/dl

13.5 ± 1.2

13.0 ± 1.6

13.1 ± 1.6

12.5 ± 1.4

0.0144

0.1067

0.0000

RBC (%)

40.4 ± 3.3

39.0 ± 4.2

39.3 ± 4.5

37.4 ± 4.0

0.0367

0.1499

0.0000

Platelets (103/ul)

200.5 ± 47.3

205.5 ± 56.2

196.3 ± 57.0

193.7 ± 45.3

0.5632

0.6641

0.4206

Na (mEq/L)

142.1 ± 2.8

142.3 ± 2.6

141.8 ± 2.4

141.1 ± 3.3

0.5636

0.6344

0.0790

 K (mEq/L)

4.3 ± 0.4

4.3 ± 0.4

4.3 ± 0.5

4.3 ± 0.4

0.5925

0.5723

0.5034

Cl (mEq/L)

105.8 ± 3.1

106.1 ± 2.9

105.8 ± 2.9

104.6 ± 4.0

0.5795

0.9289

0.0659

Ca (mg/dL)

9.1 ± 0.4

9.2 ± 0.4

9.1 ± 0.3

9.1 ± 0.4

0.6111

0.8089

0.4931

Hypertension (%)

40%

66%

53%

57%

0.0014

0.1598

0.0677

Diabetes (%)

16%

28%

26%

25%

0.0839

0.1802

0.2282

Hyperlipidemia (%)

30%

38%

35%

28%

0.3281

0.5112

0.7950

CAD (%)

5%

9%

6%

14%

0.4334

0.7831

0.1122

Stroke (%)

4%

10%

5%

9%

0.1583

0.7179

0.2027

CKD (%)

2%

13%

15%

17%

0.0207

0.0122

0.0050

COPD (%)

18%

15%

26%

34%

0.7218

0.2759

0.0411

Osteoporosis (%)

19%

29%

34%

45%

0.1836

0.0733

0.0030

  1. Con: control; LPF: loss of physical function; S: sarcopenia; SS: severe sarcopenia. Group definition is according to the Asian Working Group for Sarcopenia (AWGS) 2019 definition and algorithm
  2. BMI: body mass index; ASMI: appendicular skeletal muscle mass index; HGS: handgrip strength; GS: gait speed; HbA1c: glycosylated hemoglobin; LDL: low density lipoprotein; HDL: high density lipoprotein; Chol: cholesterol; TG: triglyceride; BUN: blood urea nitrogen; AST: aspartate aminotransferase; ALT: alanine aminotransferase; ALKP: alkaline phosphatase; WBC: white blood cell; RBC: red blood cell; T4: 3,5,3’,5’-L-tetraiodothyronine; TSH: thyrotropin; CAD: coronary artery disease; CKD: chronic kidney disease; COPD: chronic obstructive pulmonary disease