Association between BMI trajectories in late-middle age and subsequent dementia risk in older age: a 26-year population-based cohort study

Table 3 The association between BMI trajectories in late-middle age and risk of dementia in older age

Trajectory	Model1				Model2				Model3				Model 4
Trajectory	No.participants	No.event	RR (95% CI)	P value	No.participants	No.event	ARR (95% CI)	P value	No.participants	No.event	ARR (95% CI)	P value	No.participants	No.event	ARR (95% CI)	P value
Ascend BMI with low variation	3932	264	Reference		3920	262	Reference		3902	258	Reference		3902	258	Reference
Decline BMI with low variation	2690	226	1.25 (1.05–1.49)	0.013	2681	224	1.13 (0.95–1.36)	0.17	2674	223	1.16 (0.97–1.39)	0.113	2674	223	1.18 (0.98–1.42)	0.076
Ascend BMI with high variation	2761	225	1.21 (1.02–1.45)	0.033	2752	224	1.28 (1.07–1.54)	0.007	2741	224	1.27 (1.06–1.53)	0.01	2741	224	1.27 (1.06–1.52)	0.011
Decline BMI with high variation	1464	185	1.88 (1.56–2.27)	< 0.001	1460	185	1.79 (1.48–2.16)	< 0.001	1451	184	1.75 (1.45–2.12)	< 0.001	1451	184	1.76 (1.45–2.13)	< 0.001

BMI Body mass index
Model 1 was a univariate model for the BMI trajectory
Model 2 was additionally adjusted for sex, education, ethnicity, year of aged 65, and marital status
Model 3 was additionally adjusted for smoking status, alcohol consumption, and longstanding illness status. Model 4 was additionally adjusted for the mean BMI group

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