Table 2 Odds ratios of dementia among older adults with depression using selective serotonin reuptake inhibitors (SSRIs)/serotonin and norepinephrine reuptake inhibitors (SNRIs) compared to those receiving psychotherapy

Main analysis: SSRI/SNRI vs. psychotherapy

16.4

11.8

1.46 (0.97, 2.20)

1.36 (1.06, 1.74)^a

31.0 (6.6, 55.3)^a

 < 65 years

14.5

12.6

1.18 (0.75, 1.87)

1.23 (0.93, 1.62)

20.6 (-6.6, 47.7)

 ≥ 65 years

19.3

9.1

2.38 (1.05, 5.41)^a

1.73 (1.09, 2.75)^a

54.6 (10.2, 98.9)^a

 Male

17.5

13.0

1.42 (0.81, 2.50)

1.34 (0.95, 1.90)

29.5 (-3.5, 62.4)

 Female

15.9

11.1

1.52 (0.91, 2.54)

1.38 (1.02, 1.86)^a

32.3 (3.2, 61.5)^a

 White

15.0

8.9

1.81 (1.00, 3.27)

1.48 (1.10, 1.98)^a

38.7 (12.1, 65.4)^a

 Black

18.1

17.6

1.04 (0.62, 1.74)

0.76 (0.48, 1.19)

-25.5 (-54.1, 3.1)

 0-2

15.6

11.7

1.39 (0.83, 2.33)

1.35 (1.00, 1.81)^a

29.8 (1.2, 58.3)^a

 3-6

23.4

14.9

1.75 (0.96, 3.20)

1.39 (0.90, 2.15)

33.9 (-0.8, 68.6)

 Yes

31.3

5.6

7.67 (6.93, 8.49)^a

3.74 (1.55, 9.07)^a

155.3 (153.3, 157.3)^a

 No

16.1

12.0

1.41 (0.94, 2.13)

1.34 (1.04, 1.73)^a

29.5 (5.1, 53.8)^a

 Yes

21.4

15.5

1.49 (0.99, 2.24)

1.06 (0.80, 1.42)

6.3 (-18.1, 30.7)

 No

15.4

10.7

1.51 (0.89, 2.57)

1.49 (1.10, 2.03)^a

39.9 (9.9, 69.9)^a

 1:1 nearest neighbor PS matching

16.4

11.8

1.46 (0.97, 2.20)

1.27 (1.18, 1.37)^a

28.0 (5.1, 50.9)^a

 Removing comedications from PS estimation

16.4

11.8

1.46 (0.97, 2.20)

1.12 (1.05, 1.20)^a

22.0 (9.1, 34.8)^a