Is the association between blood pressure and cognition in the oldest-old modified by physical, vascular or brain pathology markers? The EMIF-AD 90 + Study

Table 3 Associations of blood pressure and the physical, vascular and brain pathology markers with cognition^a

	β^b(95% CI)
Systolic BP, mmHg	0.03 (-0.09 to 0.16)
Diastolic BP, mmHg	-0.02 (-0.14 to 0.10)
Physical markers
Waist circumference, cm	0.08 (-0.05 to 0.21)
Muscle mass index, kg/m²	0.17 (0.01 to 0.34)*
Gait speed, m/sec	0.22 (0.10 to 0.34)*
Handgrip strength, kg	0.33 (0.18 to 0.47)*
Vascular markers
Cardiac disease	0.03 (-0.23 to 5.26)
IMT, mm	0.04 (-0.08 to 0.17)
Distensibility coefficient, 10–3/kPa^c	0.05 (-0.08 to 0.19)
Brain pathology markers
WMH volume, % ICV^c	-0.17 (-0.30 to -0.03)*
Global cortical thickness, mm	0.14 (0.00 to 0.28)*

BP blood pressure, CI confidence interval. ^aCognition is represented by a cognitive composite z-score and a higher value represents a better score; ^bStandardized regression coefficient (except for cardiac disease which is not scaled because it is a dichotomous variable) from linear regression analysis adjusted for age, sex and years of education; ^cThese values are log transformed in the analyses. *P-value < 0.05

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