Fig. 2

A Forest plot of the interaction effects of physical, vascular and brain pathology markers in the association of systolic BP with cognition. BP: blood pressure; IMT: intima media thickness; WMH: white matter hyperintensities, SD: standard deviation. The P-Interactions on the right side of the forest plot are the p-values representing the significance of the interaction term, e.g. systolic BP * waist circumference. In addition, separate analyses associating systolic BP with the cognitive composite z-score were performed for the -1SD or + 1SD (or absence/presence of cardiac disease) values of the physical, vascular and brain pathology markers. The standardized regression coefficients with 95% confidence interval of these analyses are represented by the horizontal lines. Linear regression analyses are adjusted for age, sex and years of education. Values of the distensibility coefficient and WMH are log transformed in the analyses. B Forest plot of the interaction effects of physical, vascular and brain pathology markers in the association of diastolic BP with cognition. BP: blood pressure; IMT: intima media thickness; WMH: white matter hyperintensities, SD: standard deviation. The P-Interactions on the right side of the forest plot are the p-values representing the significance of the interaction term, e.g. diastolic BP * waist circumference. In addition, separate analyses associating diastolic BP with the cognitive composite z-score were performed for the -1SD or + 1SD (or absence/presence of cardiac disease) values of the physical, vascular and brain pathology markers. The standardized regression coefficients with 95% confidence interval of these analyses are represented by the horizontal lines. Linear regression analyses are adjusted for age, sex and years of education. Values of the distensibility coefficient and WMH are log transformed in the analyses